Growth hormone injections: Uses and side effects

Hormones play a part in nearly every major body function, including growth. If the body does not produce enough, a person may need to have growth hormone injections.

Several glands in the body produce hormones, but health experts consider the pituitary to be the master control gland. Not only does it control other glands, but it also makes the hormone that triggers growth.

The pituitary gland is in the brain below the hypothalamus. It secretes hormones in response to chemical messages from the hypothalamus.

The human growth hormone (HGH) helps to influence height, as well as build bones and muscles in the body. It is crucial for processes involved in normal human growth and development.

Genetic factors can lead to a lack of growth hormone in children. Damage to the pituitary gland is a common cause of a deficiency in adults.

In this article, we look at the reasons to use HGH, the function of growth hormones, and possible side effects.

HGH is essential to growth, especially in children, but it is also involved in many other processes in the body, including bone density, muscle mass, and mood.

Different hormones control various body functions and processes, including growth and development, metabolism, sexual function and reproduction, and mood.

It helps process protein and increases fat breakdown to help provide the energy needed for tissue growth.

Growth hormone levels can change through the day, and physical activity plays a part.

Exercise and similar activities can cause the levels to rise naturally. Sleep, stress, and low blood sugar levels also increase growth hormone levels.

Even small changes in HGH levels affect the body.

Too little or too much growth hormone can cause significant growth problems. Too little HGH is one of the main causes of short stature and conditions such as dwarfism.

Some people use HGH because they believe it will build muscle, improve performance, or slow aging. However, the existing evidence does not support the use of HGH for these purposes.

Children with low levels of lack of growth hormone may or may not be smaller at birth. Growth problems may appear in time, for example, if they are smaller than their classmates and growing less than 2 inches a year.

Some children are unable to produce growth hormone when they are born and continue to have low levels throughout their life.

Symptoms of growth hormone deficiency in children are:

In some children, a lack of growth hormone is part of a genetic condition, but sometimes the cause of the deficiency is unknown.

In adults, a lack of growth hormone is often due to damage to the pituitary gland, which may be permanent. The damage could have occurred in childhood or adulthood.

Other causes include:

Problems in the pituitary with producing growth hormone are commonly due to a pituitary tumor.

The pituitary can be damaged by the tumor itself or by treatment such as surgery and radiotherapy.

In adults, a lack of HGH can cause a number of different problems including:

Growth hormone deficiency can also be a combination of one or more hormone deficiencies.

Some medical conditions may also benefit HGH treatment.

These include:

The most common treatment in both adults and children is growth hormone therapy using lab-developed HGH injections.

Doses occur several times per week or on a daily basis depending on how severe the deficiency is.Manufacturers designed the growth hormone to mimic the behavior of natural growth hormone in the body. It will be prescribed by a doctor.

HGH treatments can be self-administered or given by a doctor. Treatments are often given for several years. Patients will see their doctor every month or so to check their condition.

Blood tests will be carried out to see if extra growth hormone is needed and if treatments should be increased, decreased, or stopped. Cholesterol levels, blood sugar levels, and bone density will also be checked to see if they are healthy.

Taking growth hormone can affect the bodys response to insulin, which controls blood sugar levels. Growth hormone deficiency can also lead to high cholesterol and brittle bones if it is not treated.

Specific treatment for growth hormone deficiency depends on the person.

Doctors base this treatment on certain factors, such as:

The earlier the lack of growth hormone is treated in children, the better chance they have to grow to a near normal adult height.

Children can gain as many as 4 inches or more over the first 3 years of treatment. Another 3 inches or more can grow during the next 2 years.

Many adults have to take HGH treatment for the remainder of their life.

Anyone taking HGH will undergo regular monitoring to assess the safety and effectiveness of the hormone.

The goal of growth hormone treatments in adults and children is to restore energy, metabolism, and enhance body development or shape. It can help to reduce total body fat, especially around the belly.

HGH injections can also help to improve strength and exercise tolerance and reduce the risk of heart disease in those who lack growth hormone.

Many people experience an increase in overall quality of life.

Most people tolerate HGH injection treatments well with few problems.

However, possible side effects include:

Those who experience these symptoms or other problems should talk to their doctor. They can change the dose if necessary to help remedy the symptoms.

HGH injections are not recommended for people who have:

HGH can affect insulin usage in the body, so people with diabetes should monitor their blood sugar levels carefully.

Other treatments may be required depending on the cause of the HGH deficiency.

Surgery or radiation may be necessary to treat a tumor in the pituitary. Pituitary hormones may also have to be taken to correct a gland that is not working properly.

If the levels of HGH are too high in adults, they may experience:

Long-term use of HGH injections can cause a condition called acromegaly.

Adults cannot grow taller by using the synthetic growth hormone. High doses will thicken the persons bones instead of lengthening them.

People with acromegaly will experience an overgrowth of bones, particularly in the hands, feet, and face.

The skin area can also be affected and may turn thick, coarse, and hairy. The excess HGH levels can also lead to high blood pressure and heart disease.

HGH injections have also become popular for nonmedical usage. Bodybuildersgro and athletes sometimes use them in an effort to get larger muscles, more energy, and increased stamina.

They are considered performance-enhancing drugs and are banned in professional sports.

HGH injections are also advertised as an anti-aging or weight loss treatment.

Many people aim to help increase their energy as well as fight the decrease in muscle and bone mass that happens with aging.

The Endocrine Society do not recommend HGH injections for adults or children unless they have a growth hormone deficiency.

Not enough evidence is available to prove that HGH injections can slow down the aging process, and studies show it does not improve athletic performance. Adverse effects often occur, especially fluid retention.

Using them for any nonmedical reason is illegal in the United States.

HGH injections are designed for adults or children who have a lack of growth hormone and should only be prescribed by a doctor.

Children and adults with low levels of growth hormone should ensure they have plenty of sleep, a balanced diet, regular exercise, and that they follow medical advice.

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Growth hormone injections: Uses and side effects

Anisha Joshis top tips for keeping your spine and joints healthy – Vanity Fair

Over the past 13 years working as an osteopath, Ive treated a plethora of people from different age groups and all walks of life including professional athletes, world-famous pop stars, office workers and stay-at-home parents.

With this experience, Ive discovered that certain habits can have a huge impact on our overall health. Thankfully, with a few small adjustments and a more mindful attitude, these aches and pains can be eased, and in the long run, more serious chronic conditions can be prevented.

Ive put together some of the most common reasons I see people in my clinic and ways in which you can avoid causing pain:

This is such a major one and it affects almost everyone. When youre walking down the street or on public transport it's highly likely that the majority of people in view will be on their phones. In the clinic, Ive seen a huge increase in the number of patients coming in with neck and shoulder tension and I honestly attribute this to the amount of time we spend looking down at our phones. If you think about it, our head weighs almost a stone, so when we look down it naturally increases the amount of pressure on our neck and shoulder muscles. If we are doing this for a large part of the day, it will have a huge impact on neck pain and could also lead to headaches.

Lack of movement is a particularly common issue, especially after the past year of working from home and spending a lot more time indoors. I always say that the only bad posture is one that you stay in for far too long. Our bodies were created to move and prolonged periods of time sitting in the same position does a lot more damage than you might think, causing pain to the anterior part of your hip, lower back and neck. When I preach the importance of movement, I dont mean running marathons or sprinting around your house, something as simple as stretching at your desk or grabbing a glass of water from your kitchen can still do the world of good.

You dont need me to tell you how important drinking enough water is but you might not know the impact it has on our joints. As well as maximising our physical performance, enhancing energy levels and helping with headaches, water helps to keep our joints lubricated and flexible. The synovial fluid that lubricates your joints is made up of water and reduces friction between joints and helps to maintain healthy tissue.

I wholeheartedly advocate having an omega rich diet. Omega-3 can be found in oily fish like mackerel and salmon, nuts, plant oils and the correct supplements. Omega-3 works to keep joints supple with higher levels present in synovial fluid correlating to a reduction in joint pain. It also works to strengthen bones, working with Vitamin D to increase calcium absorption and bone density.

Stress can lead to a number of physical ailments and issues, manifesting itself in different ways. Anxiety can cause physical symptoms such as jaw clenching, shrugged shoulders, insomnia, hyperventilation and IBS. These symptoms can then impact the muscles associated with these areas causing muscle tension and tightening which then leads to pain. This ultimately leads to a cycle of pain and anxiety, with both impacting one another. Practising mindfulness and looking at potential stressors and how to minimise them can positively impact your overall health.

Studies suggest that a lack of sleep can be linked to an increased chance of musculoskeletal pain. Not only is sleep vital for your mind, it also aids repair in your muscles and joints, and allows your body to rest and recover. When we sleep, our bodies release their own growth hormone which then aids muscle repair. When our sleep is disturbed, it affects the hormone secretion and can impair how quickly something like sciatica or neck pain resolves when caused by muscle tension.

Strength training is particularly important for our bodies, increasing bone density and building muscle strength. If youre able to, I recommend working with a trainer who can watch your form. If thats not possible, my advice would be to take things slowly and gradually, building up your weight and reps. Its easy to go into the gym and try to lift too heavy, too soon which in turn, can occasionally lead to injuries and strains.

Learn more about Anisha and her services here or @OsteoAnisha.

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Anisha Joshis top tips for keeping your spine and joints healthy - Vanity Fair

Short Bowel Syndrome Market Research Report by Drug Class, by Region – Global Forecast to 2026 – Cumulative Impact of COVID-19 – Yahoo Finance

Short Bowel Syndrome Market Research Report by Drug Class (GLP-2, Glutamine, and Growth Hormone), by Region (Americas, Asia-Pacific, and Europe, Middle East & Africa) - Global Forecast to 2026 - Cumulative Impact of COVID-19

New York, July 19, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Short Bowel Syndrome Market Research Report by Drug Class, by Region - Global Forecast to 2026 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06087677/?utm_source=GNW

The Global Short Bowel Syndrome Market size was estimated at USD 864.06 Million in 2020 and expected to reach USD 1,026.86 Million in 2021, at a Compound Annual Growth Rate (CAGR) 19.18% from 2020 to 2026 to reach USD 2,476.11 Million by 2026.

Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR GBP, JPY, and AUD. It helps organization leaders make better decisions when currency exchange data is readily available. In this report, the years 2018 and 2019 are considered historical years, 2020 as the base year, 2021 as the estimated year, and years from 2022 to 2026 are considered the forecast period.

Market Segmentation & Coverage:This research report categorizes the Short Bowel Syndrome to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Drug Class, the Short Bowel Syndrome Market was studied across GLP-2, Glutamine, and Growth Hormone.

Based on Geography, the Short Bowel Syndrome Market was studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific is further studied across China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa is further studied across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, and the long-term effects are projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlying COVID-19 issues and potential paths forward. The report delivers insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecasts, considering the COVID-19 impact on the market.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies to help the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. It describes the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth during a forecast period.

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Short Bowel Syndrome Market based on Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Market Share Analysis:The Market Share Analysis offers the analysis of vendors considering their contribution to the overall market. It provides the idea of its revenue generation into the overall market compared to other vendors in the space. It provides insights into how vendors are performing in terms of revenue generation and customer base compared to others. Knowing market share offers an idea of the size and competitiveness of the vendors for the base year. It reveals the market characteristics in terms of accumulation, fragmentation, dominance, and amalgamation traits.

Company Usability Profiles:The report profoundly explores the recent significant developments by the leading vendors and innovation profiles in the Global Short Bowel Syndrome Market, including 9 Meters Biopharma, Inc., Adocia SAS, Ardelyx Inc, AstraZeneca PLC, Emmaus Life Sciences, Inc., Johnson & Johnson Services, Inc., Merck KGaA, Mylan N.V., Naia Pharmaceuticals, Inc., Nestl S.A.,, Novartis International AG, Nutrinia Ltd, OPKO Health Inc., OxThera AB, Pfizer Inc., PhaseBio Pharmaceuticals Inc., Sancilio & Company Inc, Shire PLC, Swedish Orphan Biovitrum AB, Teva Pharmaceutical Industries Ltd, VectivBio AG, and Zealand Pharma A/S.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyze penetration across mature segments of the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, certification, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and breakthrough product developments

The report answers questions such as:1. What is the market size and forecast of the Global Short Bowel Syndrome Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Short Bowel Syndrome Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Short Bowel Syndrome Market?4. What is the competitive strategic window for opportunities in the Global Short Bowel Syndrome Market?5. What are the technology trends and regulatory frameworks in the Global Short Bowel Syndrome Market?6. What is the market share of the leading vendors in the Global Short Bowel Syndrome Market?7. What modes and strategic moves are considered suitable for entering the Global Short Bowel Syndrome Market?Read the full report: https://www.reportlinker.com/p06087677/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Short Bowel Syndrome Market Research Report by Drug Class, by Region - Global Forecast to 2026 - Cumulative Impact of COVID-19 - Yahoo Finance

New Cheese Products and New Recipes from Andrew & Everett – Food & Beverage Magazine – Food & Beverage Magazine

Andrew & Everett,aleadingnaturalcheese brand,revolutionized the clean cheese industry over 20 years ago byintroducingthe firstrBGH-BST hormone-free cheese in the U.S.,raising the bar on the industry standard.Andrew & EverettAmerican CheeseistheonlyAmerican Cheese sliced fresh from the delitogain national acclaimfromWhole FoodsMarket,meeting the highest standards of any American Cheese.

The full line ofAndrew & Everettpre-sliced cheesesincludesYellow and White American,Swiss, Mild Cheddar, Mozzarella, Pepper Jack, Colby Jack, Havarti, Muenster,andProvolone. They are creamy,delicious,andperfectfor melting on burgersandwonderfuladditions tosnacks and sandwichesat yoursummerpicnics.

Theirline ofAmerican Cheeseparticularly stands out against other brands, asAndrew & Everett AmericanCheeseismade with natural aged Cheddar and aged Monterey Jack cheese, not leftover ends, or pieces. It has no artificial preservatives, colors, no sugars added, no soy or soy lecithin, no whey or whey protein concentrates, no milk protein concentrates or calcium phosphates, and isrBGH-BST hormone free.

AtAndrew & Everett,we believethat cheese should tasteamazingjust the way it is.Thatiswhywestart with thehighestquality milkfromgrass-fed cowsthat areraisedhumanely on family-ownedfourth generationfarmsthroughout Americas Heartland,says Kevin Rider, Senior Brand Manager ofAndrew & Everett.This produces a delicious, creamier tasting cheese thats free fromartificialhormones and preservatives and only has recognizable ingredients you can pronounce,adds Rider.

The cheesemakers atAndrew & Everetttake anauthentic approach to cheesemaking, turning milk to cheese in 48 hours by master artisan cheesemakers local to where the cowsareraised. This special process is essentialinproducing a fresher, creamier, better tasting cheesewithout anyadditives or flavor enhancers.Andrew & Everettsexceptionalflavoristhe result of anunwavering effort to create a truly clean label natural,preservative andartificialhormone-free cheese that tasteslike it comes straight fromyour local farmer.

Joining thealready vastnatural cheeseline-up,Andrew & Everettintroduces NEWAndrew & EverettRustic Thick Cut Shredded Cheese,a larger cut shredthat isgreat for melting and maintains its flavor and cheesy texture when heated.It is available inSharp WhiteCheddar, Mozzarella, and Fiesta Blend varieties.

The complete line ofAndrew & EverettCheeses beyond thepre-sliced line includes:

We have one of the broadest offerings of natural, preservativefreeandartificial hormone- freecheeses that not only meets consumer needs for better-for-you, clean label cheese, but tastes exceptionally flavorful, never compromising on qualityorflavor says Kevin Rider.Hands down Andrew & Everett has the BEST AmericanCheese, adds Rider.

To inspireyour summergrilling, try this Philly Grilled Steak and Cheese Sandwich

INGREDIENTS

PREPARATION

Serving 1

For anamazingsummerappetizer,trythisAmericanCheeseCon QuesoDip:

INGREDIENTS

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Serving 6-8

About Andrew & Everett

Andrew & Everettcheeses offer natural, clean label, preservative andhormone-free products from grass-fed cowsraised onsmall,fourthgenerationfamily-owned farmsin the heartland of America. Each farm has around only 15 heads of cattle, allowing for smaller batches of cheese that are all produced from the first run of the day, to ensure no cross-contamination and the cleanest cheese possible. The farm-to-tablefreshness is also ensured, as the milk is made into cheese within 48 hours by master and artisan cheese makers. Their productsare made with vegetarian rennet,contain no antibiotics,artificialhormones,artificialpreservatives, artificial colors,binders,or fillers, and are gluten-free. No cows are injected with syntheticrBGH-BST growth hormones or fed animal by-products. No antibiotics are used for any of their cows, so if cows become ill and antibiotics are necessary, they are removed from the dairy herd and their milk is used for conventional cheese. AllAndrew & Everettproducts are produced in gluten-free facilities and tested on a regular basis to ensure the non-presence of glutens.Andrew & Everettcheeses are the only American variety of cheeses sold at Whole Foods, meeting the highest standards.

Their national distributioncoversanextensivelist ofnationalfirst-ratenatural/specialtyretailers and exceptional standards of ingredients and production placeAndrew & Everettin thetop tierofassisting consumers in making clear, informed decisions about the healthy foods they choose.

For more information, please visithttps://andrewandeverett.com/

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New Cheese Products and New Recipes from Andrew & Everett - Food & Beverage Magazine - Food & Beverage Magazine

Growth Hormone Deficiency Market is expected to reach $5.80 Million by 2028: COVID Impact, Opportunities, Trends and Forecast Murphy’s Hockey Law -…

Evolve business intelligence, today has published a new market research report on The global Growth Hormone Deficiency market size was valued at $3.13 Billion in 2020 and is expected to reach $5.80 Million by 2028 growing at the CAGR of 7.99% from 2021 to 2028.

For more information on the report: https://report.evolvebi.com/index.php/sample/request?referer=murphyshockeylaw.net&reportCode=002042

The COVID-19 pandemic has led to disruption in the supply chain leading to lower demand or supply shortages in the growth hormone deficiency market. The travel restrictions and social-distancing measures have resulted in a sharp drop in consumer and business spending and this pattern is expected to continue for some time. The end-user trend and preferences have changed due to the pandemic and have resulted in manufacturers, developers, and service providers adopting various strategies to stabilize the company.

In terms of COVID 19 impact, the growth hormone deficiency market report also includes the following data points:

The recent COVID scenario is expected to have a positive impact on the growth hormone deficiency market. Due to the increasing spread of Coronavirus, several companies are working with a limited workforce leading to delays in work/production. This has impacted the market in the years 2020 and 2021.

Competitive ScenarioSome of the major growth hormone deficiency players holding high market share include Novo Nordisk A/S, Pfizer Inc, Novartis AG, Anhui Anke Biotechnology (Group) Co., Ltd. These players use new product development, partnership, and acquisition as key strategies to gain significant market share to compete with market leaders.

Segmental AnalysisThe growth Hormone Deficiency market is analyzed across the below-mentioned different segments:

Report CoverageThe study also contains a comprehensive value chain, as well as details on the key factors affecting the market growth (drivers, constraints, and opportunities). Furthermore, the report includes 10 key players in the growth hormone deficiency market ecosystem that have been strategically profiled, along with the market ranking/share for major players. Under the company profile section, the companys core competencies have been comprehensively analyzed, along with detailing the competitive landscape for the market players, and the strategies such as partnerships and collaboration, acquisitions, product launches and developments, contracts, and business expansion adopted by them to grow in the market.

The key players profiled in the report are:

To request a free sample report https://report.evolvebi.com/index.php/sample/request?referer=murphyshockeylaw.net&reportCode=002042

Research MethodologyThis research study makes substantial use of secondary sources, archives, and databases (such as annual reports, news releases, magazines, Trademap, company websites, and other paid databases) to classify and gather information valuable for this analysis. The entire process involves a review of top industry participants financial records. Following the determination of the overall market size, the total market was divided into several segments and sub-segments, and this information was then verified through key industry specialists such as CEOs, directors, VPs, and marketing executives.

Report Objectives

About EvolveBIEvolve Business Intelligence is market research, business intelligence, and advisory firm providing innovative solutions to challenging pain points of a business. Our market research reports include data useful to micro, small, medium, and large-scale enterprises. We provide solutions ranging from mere data collection to business advisory.

Evolve Business Intelligence is built on account of technology advancement providing highly accurate data through our in-house AI-modelled data analysis and forecast tool EvolveBI. This tool tracks real-time data including, quarter performance, annual performance, and recent developments from fortunes global 2000 companies.

AddressEvolve Business IntelligenceC-218, 2nd floor, M-CubeNH 48, Balitha, VapiGujarat 396191India

Contact: +1 773 644 5507 / +91 635 396 3987Email: [emailprotected]Website: https://evolvebi.com/

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Growth Hormone Deficiency Market is expected to reach $5.80 Million by 2028: COVID Impact, Opportunities, Trends and Forecast Murphy's Hockey Law -...

Everything you need to know about Jeep – Top Gear Philippines

Whats Jeep, and when did it start making cars?

Jeep is an American manufacturer of 4x4s and SUVs, as well as a source of subtly branded clothing to illustrate your affinity for all things off-road and Murican. Or at least your affinity for cut-price clothing bins.

Jeeps start date is officially 1943, when the trademark application was first lodged. But then the company claims it kicked off in 1941. Um. Right.

Really, Jeeps birthday (and etymology) is fuzzier than the three-day growth of the GIs who drove them. Was it March 1941, the anything goes era where prototypes and pre-production models got the nod and were press-ganged into duty? Was it July 1941, when full production started? Or maybe April 1942, when that same army was awarded the patent for its design, despite the fact that it was the work of Willys, Ford, and Bantam? And how did we get the name Jeep in the first place?

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Its probably easiest to just say the 40s and great question before changing the subject. Theres an idea that Jeep comes from the Ford GPW, much like the Humvee came from HMMWV, but another idea that it comes from an old Popeye character called Eugene the Jeep. But did you really come here for a history lesson?

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And that, kids, is how you change the subject.

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Mostly in America, as youd expect. Given its iconic status and proclivity for a bit of parochial pride, Jeeps tend to be built in the US of A, generally in towns that wouldnt look too out of place in the opening half of The Deer Hunter. Of course, theres a plant in Mexicoa company cant be truly American until its outsourced something to its southern cousinsand apparently a total of 10 plants across six countries, including the US and Mexico.

Jeep has also had factories in roughly every country a sixth-grader could point to on a map, and unlicensed copies of its most famous vehicle have cropped up across Asia as well as in Europe and the Americas. Well-traveled, you might say.

In terms of sales, you can generally expect between one million and 1.8 million sales a year. Which, presumably, means about the same number of cars built in the same period. Recent hits to supply chains, microchips, and so on are sure to have hurt things (and put a severe dampener on plans to double Jeep sales by 2023), but it keeps trucking along, as it were.

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No cars, if were being pedantic. Thats kind of what the last line of the last paragraph was alluding to: Jeep builds trucks. Not, like, truck trucksthats the preserve of Ram, which is like if Chevrolet created an entire brand to sell commercial vehicles. Ram, like Jeep, is under the Stellantis umbrella, which is the new, larger umbrella made by stitching the Fiat-Chrysler umbrella to the Peugeot-Citroen umbrella and hoping nothing leaks. But we digress.

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Jeep is known for the Wrangler, an off-roader that rides on a truck-ready ladder frame. It also makes the Gladiator, a pickup truck based on the Wrangler off-roader that rides on a truck-ready ladder frame. Simple.

There are also SUVs that should really not be called the Cherokee and the Grand Cherokee anymore, surely. In any case, they break the mold by having unitary bodies, like youd find in a car, but a lot more ground clearance than youd find in a normal car.

The Wagoneer is making a comeback after three decades as a full-size SUV, which is Americanese for a vehicle the size of a mining truck. It used to beyou guessed ita ladder-frame-based heffalump, but will join the rest of us in the Anthropocene and offer a unitary body this time around. Just kiddingits going on the same ladder frame that underpins the Ram 1500 pickup. Mm. Refined.

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Then there are the little SUVs and crossovers that try their damndest to be a real Jeep, with all the Jeep badging and jingoistic names like Patriot and Renegade. Honestly, theyre interchangeable enough that you might not even notice one of those weve just mentioned hasnt been on sale for years. The Renegade, on the other hand, might be the best combination of ironic and adorable weve ever encountered. Look at that little face! It may as well come as standard with a sticker that says, When I grow up, Im going to be a Wrangler.

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The cheapest is going to be the little Renegade, rolling all the way up to the big daddy Grand Wagoneerthat is, if the Wagoneer is coming to your neck of the woods. Otherwise, its going to be the Grand Cherokee L, a three-row SUV with a slightly smaller unitary body.

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Well, its definitely going to have Trackhawk in the name there somewhere, given that its how Jeep denotes its Hemi-powered Lance missiles. In particular, its the Grand Cherokee Trackhawk, replete with a 700hp supercharged V8, a 0-100 sprint in the low-threes, and a claimed top speed of 290kph. So, quick enough, no?

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Were going with the jeepney. For those of you who havent been to the Philippines, the jeepney is the kind of vehicle thatd make MacGyver tumescent.

Jeepneys started life as surplus Army Jeeps, left behind after the Americans kicked the Imperial Japanese out of the Philippines toward the end of World War II. But because the Japaneseand some pretty serious American shellinghad destroyed pretty much everything, including fleets of taxi-share cars, Filipinos got creative.

Simple Army Jeeps were reborn as proper passenger buses, operating as cheap share-taxis and getting the Philippines moving again. Decades later, the ornately decorated, MacGyvered-together buses are still the cheapest way to get around Manila. Jeepneys are, to all intents and purposes, a cultural icon, like Londons double-decker buses or the canary-yellow cabs of New York. Okay, theyre about as safe and environment-friendly as a fracking rigwhich is a big part of why theyre being forced out in favor of safer, cleaner transportbut after more than seven decades of faithful service, theyve probably earned their keep. And, were sure, would continue to do so for decades yet.

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Really, the victory is more Filipino than American, but for creating a vehicle with such incredible ruggedness, simplicity, and utility, well still hand a best moment nod to Jeep.

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Easy one, this: the Jeep Commander. So bad, even the boss hated it. The late Sergio Marchionne was reported to have said it was unfit for human consumption, and that despite selling some, I dont know why people bought them.

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Oof.

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Lets make this answer multiple-choice, no? Because thats definitely how answers work.

For some, it might be spinning an entire car company, ethos, and mythos off a simple wartime conveyance. For others, it could be the sheer number of companies whove owned Jeep since its inception in the 40sfirst Willys, then Kaiser, AMC (with a bit of Renault input), then Chrysler in three different guises (Chrysler, Daimler-Chrysler, then Fiat-Chrysler), before settling in under the vast agglomeration that is Stellantis.

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Or, of course, it could be that time Jeep launched the then-new Grand Cherokee by driving it through a plate glass window.

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Jeep, especially recently, has done some staggeringly good concept cars, from best-of restomods to insane, barrel-chested off-road monsters that should run on human growth hormone, not gasoline. And they take them all out to Moab every Easter to use them as Our Lady of Blessed Acceleration intended. None of this careful, its just a concept car nonsense; these are proper things that work properly.

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Our favorite, unequivocally, is the Wagoneer Roadtrip concept. We like it so much, in fact, that weve already written a story about it.

PHOTO BY TopGear.com

When someone from Jeep says that one of its vehicles is an icon, itd be fairly easy to dismiss it as regular-strength American braggadocio and move on with our lives. But when theyre talking about something thats not only the most iconic vehicle from historys greatest conflict, but also a bona fide design icon, it might actually be time to pay attention.

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In fact, the Jeep M38A1 is the only American vehicle on display in Manhattans Museum of Modern Art, in among an ultra-rare Cisitalia 202, an E-Type roadster, a Citroen DS, a first-gen Porsche 911, and the prettiest Formula 1 car of our generation, the Ferrari 641. Not a bad effort for one of the most utilitarian vehicles ever created.

NOTE: This article first appeared on TopGear.com. Minor edits have been made.

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Everything you need to know about Jeep - Top Gear Philippines

Hormone Replacement Therapy Market Covid 19 Overview: Demand Analysis and Growth Opportunities by 2027: F. Hoffmann-La Roche, Merck Serono, Novartis,…

The Hormone Replacement Therapy Market research report provides an analysis of major manufacturers, geographic regions, and provides advanced information about the major challenges that will affect market growth. The report includes definition, classification, application and industrial chain structure, development trend, analysis of the competitive landscape, and analysis of distributors in key regions. The report also provides supply and demand data, revenue, and share.

The report provides in-depth knowledge about the utilization and adoption of the Hormone Replacement Therapy industry in various applications, types, and regions/countries. In addition, the main stakeholders can identify the main trends, investments, driving factors, initiatives of vertical players, the governments pursuit of product acceptance in the next few years, and insights into the commercial products that exist in the market.

According to the report, the market is appropriately divided into important segments.

Segmentation by Compitetion

The competitive landscape of the global Hormone Replacement Therapy market is fragmented. The emergence of a large number of key players is the main reason for such fragmentation in the global market. In the next few years of the forecast period, global market competition is expected to only intensify. The market leader like F. Hoffmann-La Roche, Merck Serono, Novartis, Novo Nordisk, Pfizer, Abbott Laboratories, ANI Pharmaceuticals, Bayer, Eli Lilly, Hisamitsu Pharmaceutical, Merck, Mylan Laboratories, has invested a lot of money in research and development activities.

Segmentation by Region

The global Hormone Replacement Therapy market has five main regional segments, divided by geographic region. These regions are North America, Europe, Asia Pacific, Middle East-Africa, and Latin America.

Segmentation by Type

Estrogen replacement therapy, Growth hormone replacement therapy,

Segmentation by Application

Oral, Parenteral, Transdermal,

Impact of COVID-19:

The industry is mainly driven by increasing financial incentives and regulatory support from governments around the world. The current Hormone Replacement Therapy market is mainly affected by the COVID-19 pandemic. Hormone Replacement Therapy Market document looks into the impact of Coronavirus (COVID-19). Since December 2019, the COVID-19 contamination spread to nearly 180+ countries around the sector with the World Health Organization pronouncing it a popular well-being crisis. The worldwide consequences of the Covid contamination 2020 (COVID-19) are actually starting to be felt, and could basically have an effect on the Hormone Replacement Therapy market in 2021. Most projects in China, the United States, Germany, and South Korea have been postponed. These companies are facing short-term operational problems due to supply chain constraints and the inaccessibility of factories due to the COVID-19 outbreak. Due to the pandemic impact in China, Japan, and India, the spread of COVID-19 is expected to severely affect the Asia-Pacific region.

Frequently Asked Questions

What does the report cover?The report incorporates an analysis of factors that promote market growth. The report introduces the competitive landscape of the global market. This also provides a range of different market segments and applications that may affect the market in the future. The analysis is based on current market trends and historical growth data. It includes detailed market segmentation, regional analysis, and industry competition pattern.

Does the report estimate the current market size?The report effectively assesses the current market size and provides industry forecasts. The value of this market in 2019 is $XXX million, and the compound annual growth rate during 2021-2027 is expected to be XX%. (*Note: XX values will be given in final report)

How does the report provide the market size of the market?The report effectively assesses the current market size and provides forecasts for the industry in the form of Value (millions USD) and transaction Volume (Thousands Units)

What market dynamics does this report cover?The report shares key insights on:

It helps companies make strategic decisions.

Does this report provide customization?Customization helps organizations gain insight into specific market segments and areas of interest. Therefore, WMR provides customized report information according to business needs for strategic calls.

Hormone Replacement Therapy Market 2021-2027: Main Highlights

Contact Us:

Mr. ShahWorldwide Market Reports,Tel: U.S. +1-415-871-0703 / U.K. +44-203-289-4040 / Japan +81-50-5539-1737Email: sales@worldwidemarketreports.com

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Hormone Replacement Therapy Market Covid 19 Overview: Demand Analysis and Growth Opportunities by 2027: F. Hoffmann-La Roche, Merck Serono, Novartis,...

Human growth hormone (HGH): Does it slow aging? – Mayo Clinic

Human growth hormone (HGH): Does it slow aging?

Human growth hormone is described by some as the key to slowing the aging process. Get the facts about these claims.

Growth hormone fuels childhood growth and helps maintain tissues and organs throughout life. It's produced by the pea-sized pituitary gland located at the base of the brain. Beginning in middle age, however, the pituitary gland slowly reduces the amount of growth hormone it produces.

This natural slowdown has triggered an interest in using synthetic human growth hormone (HGH) as a way to stave off some of the changes linked to aging, such as decreased muscle and bone mass.

If you're skeptical, good. There's little evidence to suggest HGH can help otherwise healthy adults regain youth and vitality. Alternatively, HGH treatments may increase the risk of other medical conditions. Experts recommend against using HGH to treat aging or age-related conditions.

Adults who have a growth hormone deficiency not the expected decline in growth hormone due to aging might be prescribed synthetic HGH by their doctors.

In most people, growth hormone deficiency is caused by a benign tumor on the pituitary gland (pituitary adenoma) or by treatment of an adenoma with surgery or radiotherapy.

For adults who have a growth hormone deficiency, injections of HGH can:

HGH treatment is also approved to treat adults with AIDS- or HIV-related growth hormone deficiency that causes irregular distribution of body fat.

Studies of healthy adults taking human growth hormone are limited and contradictory. Although it appears that human growth hormone can increase muscle mass and reduce the amount of body fat in healthy older adults, the increase in muscle doesn't translate into increased strength. It isn't clear if human growth hormone provides other benefits to healthy adults.

HGH treatment might cause a number of side effects for healthy adults, including:

Clinical studies of HGH treatment in healthy older adults have been relatively small and short in duration, so there's little to no information about the long-term effects of HGH treatment.

HGH treatment is approved in the United States only for treatment of growth hormone deficiency and related problems associated with HIV infection. HGH is only effective if administered as an injection.

There's no pill form of human growth hormone available. Some dietary supplements that claim to boost levels of HGH come in pill form, but research doesn't show a benefit.

HGH is considered a controlled substance by the Food and Drug Administration. Using HGH for a condition that isn't approved, such as building muscle or as an anti-aging treatment in older adults, is illegal.

If you have specific concerns about aging, ask your doctor about proven ways to improve your health. Remember, healthy lifestyle choices such as eating a healthy diet and including physical activity in your daily routine can help you feel your best as you get older.

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Human growth hormone (HGH): Does it slow aging? - Mayo Clinic

Growth hormone receptor – Wikipedia

A protein involved in the binding of the growth hormone

Growth hormone receptor is a protein that in humans is encoded by the GHR gene.[5] GHR orthologs[6] have been identified in most mammals.

Growth hormone receptor (GHR) is transmembrane proteins consisting of 620 amino acids. GHR exists in two forms as a full length membrane-bound receptor and as a soluble GH binding protein (GHBP).[7] GHR contains two fibronectin type III domains in its extracellular domain, whereas the intracellular domain contains tyrosine Kinase JAK2 binding sites for SH2 proteins. JAK2 is the primary signal transducer for growth hormone.[8]

This gene encodes a protein that is a transmembrane receptor for growth hormone.[9][10] Binding of growth hormone to the receptor leads to reorientation of a pre-assembled receptor dimer dimerization (the receptor may however also exist as monomers on the cell surface [11]) and the activation of an intra- and intercellular signal transduction pathway leading to growth.[12] A common alternate allele of this gene, called GHRd3, lacks exon three and has been well characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature (proportional dwarfism). Other splice variants, including one encoding a soluble form of the protein (GHRtr), have been observed but have not been thoroughly characterized.[5] Laron mice (that is mice genetically engineered to carry defective Ghr), have a dramatic reduction in body mass (only reaching 50% of the weight of normal siblings), and also show a ~40% increase in lifespan.

Growth hormone receptor has been shown to interact with SGTA,[14] PTPN11,[15][16] Janus kinase 2,[17][18][19] Suppressor of cytokine signaling 1[20] and CISH.[20]

The GHR gene is used in animals as a nuclear DNA phylogenetic marker.[6] The exon 10 has first been experienced to explore the phylogeny of the major groups of Rodentia.[21][22][23]GHR has also proven useful at lower taxonomic levels, e.g., in octodontoid,[24][13] arvicoline,[25] muroid,[26][27] murine,[28] and peromyscine [29] rodents, in arctoid [30] and felid[31] carnivores, and in dermopterans.[32]Note that the GHR intron 9 has also been used to investigate the mustelid[33] and hyaenid [34] carnivores phylogenetics.

Growth hormone receptor antagonists such as pegvisomant (trade name Somavert) are used in the treatment of acromegaly.[35] They are used if the tumor of the pituitary gland causing the acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful. Pegvisomant is delivered as a powder that is mixed with water and injected under the skin.[36]

PDB gallery

1a22: HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR

1axi: STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE

1hwg: 1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN

1hwh: 1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN

1kf9: PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR

2aew: A model for growth hormone receptor activation based on subunit rotation within a receptor dimer

3hhr: HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX

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Growth hormone receptor - Wikipedia

Selecting or Switching Formulations of Glucagon – MD Magazine

Peter Salgo, MD: Lets talk about patient factors. We alluded to it, but lets make it a bit more concrete. What are the patient factors that you consider when youre talking about the injectable treatment vs the nasal spray? Lets take the red kit out for now because Im getting a sense none of you guys really likes that very much, but it was all you had for a while. Lets look at these 2 new therapies: the injectable and the intranasal. Are there some patients who are better off with 1 rather than the other? If they like 1 or the other, can you switch from 1 class of therapy to another? Elaine?

Elaine Apperson, MD: Absolutely. You could definitely switch, but were not really talking about a patient but whos going to be administering it. I dont know that patient factors really matter as much as looking around and seeing who might be attending to that person is: spouse, nursing aide, coach, roommate, or teacher.

Peter Salgo, MD: I shouldnt have said patients. I should have said sociologic factors because thats the whole environment, right? Its the whole ecosphere.

Elaine Apperson, MD: What Davida said was also really important: insurance coverage, at the end of the day, is going to make a difference too. It makes a big difference for all of us. Look, we dont get too picky around basal and bolus insulin. We usually just go by what the insurance tells us to prescribe. Thats often the way medicine works these days. We say, We are going to use growth hormone, so we must look at the insurance. Were going to use this or that or the other. We are going to look at the insurance first. Its part of being an endocrinologist. Its really all the same in the end. Its the brand we use or what the insurance tells us to use. Unfortunately, that extends to glucagon products. Luckily, as Davida also mentioned, usually 1 or the other is covered.

Peter Salgo, MD: Is it fair to say, from what Im hearing, that its in the do not care mode? They both work; theyre both efficacious. If insurance covers 1, just buy that 1. If insurance covers the other 1, buy that?

Elaine Apperson, MD: Personally, the form factor is important: the prefilled syringe and the pen-like device is more familiar to patients with diabetes than the intranasal and injection. I have children who havent received the full dose of the intranasal glucagon when theyre seizing because theyre hard to control.

Peter Salgo, MD: In other words, its what you pointed out before. If a kid is writhing or moving around, its tough to put something in that kids nose and get the whole dose in there.

Elaine Apperson, MD: You put it in, and they suddenly jerk, and you dont know if theyve got it and youve already used 1 Baqsimi a month ago. Then what do you do?

Peter Salgo, MD: I hear what youre saying. You like the SC [subcutaneous] version better.

Elaine Apperson, MD: I do.

Peter Salgo, MD: Can we take a vote? Who likes what? Why dont we go around the horn a little. Davida, what do you like?

Davida Kruger, MSN, APN-BC, BC-ADM: I agree. I tend to like the prefilled forms of this, only because it reminds people of an EpiPen. Its easier to find a body part to be able to put it in vs having to get it in the nose.

Peter Salgo, MD: Im sorry, you just reminded mepick a body part, any body part. But it makes sense

Elaine Apperson, MD: I heard that it hurts, that the intranasal spray really hurts. One family used it a little prematurely, and the patient wasnt truly unresponsive yet, so they said it was the most painful.

Peter Salgo, MD: Really? We didnt discuss thisthe intranasal hurts?

Elaine Apperson, MD: Well, anecdotally.

Davida Kruger, MSN, APN-BC, BC-ADM: I havent heard that, but most of my patients are unconscious when I get it, so Im not sure that counts.

Elaine Apperson, MD: This poor child wasnt quite unconscious yet, and it hurt.

Davida Kruger, MSN, APN-BC, BC-ADM: Patients and family members are just grateful for using either of those as opposed to the panic when they open the red box and say, Now what do I do? Thats when the 911 call usually happens.

Peter Salgo, MD: Anne, what do you vote for?

Anne Peters, MD: My patients caregivers or family members generally prefer the intranasal glucagon because theyre used to putting nasal spray in because their sinuses are bad or whatever. Thats something they relate to. I dont have that many family members who are used to giving epinephrine, so they tend to prefer the intranasal method. But its not about me; its about them.

Davida Kruger, MSN, APN-BC, BC-ADM: Yeah.

Anne Peters, MD: I offer it, and I have samples. I ask, Which 1 do you want? We also talk about insurance coverage, but if the world were neutral, its simply what a family member wants.

Davida Kruger, MSN, APN-BC, BC-ADM: Absolutely.

Anne Peters, MD: Ive shown people both, and they take whatever they want because its about using it. Ive had patients give it to themselvesthe intranasal stuffand they say it feels like a bullet to the brain. You dont want a conscious person using glucagon intranasally because its a very strong drug and a very strong push-up. But its working. Its really spraying that stuff in the back of your nose. Dont use it for conscious patients. Thats not a good thing.

Peter Salgo, MD: My thought is that after everybody has had a year of having tongs put up their noses for COVID-19 tests, we could all be desensitized to this. Jay, what do you think?

Jay Shubrook, DO, FACOFP, FAAFP, BC-ADM: Im agnostic. I feel like its whatever youre going to fill, whatever the family is comfortable givingthats what Im going to write. Because I treat both adults and kids, its all over the map in terms of the response. I need them to have confidence that they can give it, that they can afford it, and that they will fill it. Ill use any of them because when used properly, they can all work.

Peter Salgo, MD: I want to thank all of you at home for watching this HCPLive Peer Exchange. If you enjoyed the content, I want you to subscribe to our e-newsletter to receive upcoming Peer Exchanges and other great content right in your in-box.

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Selecting or Switching Formulations of Glucagon - MD Magazine