One Thing to Add to Lower Your Cancer Risk, From a Doctor – The Beet

Before World War II, the Inuit people of the Arctic Circle never or rarely got cancer. It was largely non-existent as a disease beforethe economy opened up and brought new foods to this population. Their traditional diet was high in protein and fat but low in carbohydrates. After the 1950s their diet shifted as more imported foods of refined grains and sugars made their way up to the north and the Inuit lifestyle shifted. The rate of cancer more than doubled in ten years. The genetic makeup of the population was unchanged, but diet changed dramatically. It was just one example of how the addition of sugar, processed foods, and simple carbs can drive up cancer.

In his excellent book, The Cancer Code, Dr. Jason Fung creates a complex and complete picture of cancer:How it works, what we know about its growth, prevention, and treatment, and what we thought we knew that is now debunked, having been based on false assumptions. Cancer exists in the body at all times, but your immune system helps keep it in check, and this equilibrium is a delicate dance that is constantly happening, so anything we can do to promote our immune system and suppress cancer is worth considering.

Imagine if we could change our diets by eating natural foodsand reduce our risk of certain cancer so that, like the indigenous peoples of the Far North, we too were considered immune to cancer," Dr. Fung writes. It turns out there are things we can do to lower our risk.

Dr. Fung is a Canadian nephrologistand world-leading expert onintermittent fastingandlow-carbdiets, especially for treating people withtype 2 diabetes. He has writtenthree best-selling health booksincluding The Obesity Code.

Cancer in the US is actually on the retreat, if you look at the cancer statistics in their entirety, due to smoking cessation initiatives, and the decrease in lung cancer deaths. But other cancers are rising, especially those connected to diet and obesity, which has a directlinkto cancer risk, especially those cancers related totype 2 diabetes. The CDC says 40 percent of all cancers are now attributable to obesity, includingincreased risk of 13 types of cancer, including colorectal, breast, and pancreatic, liver, and kidney cancers, according to the NIH.

The role that diet plays in cancer is undeniable, according to the statistics Dr. Fung cites, including the fact that people who have type 2 diabetes or are obese are at an increased risk for 13 types of cancer, and the key link appears to be insulin. Insulin is a growth hormone, he explains, closely tied to IGF-1 (Insulin Growth Factor), and when cells get the signal that nutrients are available, they grow.

When cancer gets started growing, multiplying, and circulating in the bloodstream, your immune system has the ability to find it, kill it, and knock it out. This constant interplay between growing cancer cells that travel through the bloodstream looking for a new safe harbor, and the natural killer cells of your immune system, which are constantly searching and destroying foreign cells, including these cancer cells, is at play every day in our bodies. The equilibrium stays under control, most of the time, Dr. Fung explains, except if the boy is bombarded with chronic cancer-promoters, or compromised. When your insulin levels are routinely locked in overdrive, such as on a diet high in carbs and sugar, or when the immune system gets compromised or overstressed, then cancer has the chance to take hold.

Dr. Fung explains that we have fought cancer on its own terms: By fighting the growth of the cells with chemotherapy, radiation, and surgery that is designed to halt its march. Instead, he says, we should play to our own innate strengths, and find cancers weakness. Two ways of doing this are by strengthening the immune system and through our diet.

It is reasonable to hypothesize that diets targeted to reduce insulin effect may be beneficial for cancer, Dr. Fung writes, but more studies need to be done. Cancer uses glucose to fuel its growth, so sugar and diets high in simple carbs stoke the flames. Meanwhile when we eat a high-sugar diet, insulin spikes. So the first line of defense against cancer is to lower our sugar intake and stay away from simple carbs that easily turn into glucose and raise our blood sugar, causing insulin to surge in the body.

Approximately 20 percent of all cancer cases in Europe and North America are attributable to obesity, Dr. Fung writes, and intentional, dramatic weight loss can reduce the risk of cancer death by 40 to 50 percent. In a lab, mice with cancer that were given just enough food to survive, and their cancer showed no growth, whereas cancer in mice allowed to eat as much as they wanted, grew the fastest.

Calorie restriction is hard, though, so Dr. Fung suggests eating a whole food diet of nutrient-rich foods combined with intermittent fasting, which encourages autophagy in the body, allowing it time to self-cleanse, and dispose of cells that are compromised before cancer can develop.

Choosing foods that are nutrient-dense is another way to play to our bodys strength, since antioxidants, vitamins, and phytochemicalsvegetables, fruit, whole grains, legumes, nuts, and seedshelp bolster the immune system and undermine cancer. Unlike your bodys healthy cells, cancer cells dont need nutrients to grow. They respond to glucose, and when glucose is not present they will grab at any fuel they can and turn it into growth. But eating a diet rich in vegetables, fruit, herbs and whole foods helps your immune system arm itself in the fight against invaders, including cancer.

Green tea is especially high in a polyphenol called epigallocatechin gallate, (or EGCG), which has been shown to slow cancer growth, in several recentstudies have revealed. EGCG is considered a "chemopreventive polyphenol," which fights cancer in several ways. One is that it activates natural cell death, or "apoptosis" which is the orderly and healthy celldemise that takes place in the body when cells are ready to be replaced with new healthy cells. When apoptosis happens in a controlled and orderly way, cancer can not take advantage of vulnerable cells. This is no small feat since the bodyreplaces about 330 billion cells a day, or about 1 percent of your cells get carried off and replaced by design every day. When this happens in a healthy, orderly fashion, it prevents cancer from taking hold in those cells that are ready to get recycled.

EGCG also signals to a nutrient pathway called AMPK that energy is low, so it doesn't promote cell growth. AMPK acts like the bodys fuel gauge. When AMPK senses that nutrients are low it signals to the cells that they should not try to grow, since there is not enough energy present. AMPK also activates autophagy, the process your body uses to self-clean, so it can accomplish the important job of carting waste off to be disposed of safely.

The nutrient sensors in the body, insulin (which responds to carbs) mTOR (which is protein sensitive), and AMPK (which gauges the overall fuel supply to the cells) all signal to the cells to grow. But EGCG appears to tell the cells: Don't grow, and actually, burn fat instead.

Studies have shown that taking green tea extract (as opposed to simply drinking it) helps with weight loss, promoting fat burning, and helping burn belly fat. EGCG also lowers cancer risk, which is a rare natural food that can have such a powerful effect. If you add one thing to your healthy whole food diet, to lower cancer risk, it should be a daily cup (or more) of green tea or taking green tea extract, Dr. Fung writes.

Green tea, which is higher in EGCG than black tea, can help reduce some of the risk factors of cancer, such as promoting weight loss, lowering insulin resistance, fighting inflammation, and helping to prevent type 2 diabetes, according to Dr. Fung. A study of women in Japan found that high consump[tion of green tea delayed breast cancer onset by over 7 years, and reduced breast cancer recurrence in those who had it once. Green tea is one of the few chemopreventive tools that is a low-cost, natural food with no negative side effects.

Bottom Line: According to Dr. Fung, If you are overweight, lose weight. Do whatever you can to avoid or reverse type 2 diabetes.If you have type 2 diabetes consider taking metformin, which can help reduce the risks of insulin. And drink more green tea.

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One Thing to Add to Lower Your Cancer Risk, From a Doctor - The Beet

Procalcitonin Antibody Market: Innovative products for the treatment of diseases such as cancer boost the growth of the market – BioSpace

Procalcitonin (PCT) is a peptide precursor of the calcitonin hormone. Procalcitonin is a peptide that contains 116 amino acids and has an estimated molecular weight of 14.5 kDa. It can be separated into three parts: immature calcitonin, amino terminus of the PCT region, and calcitonin carboxyl-terminus peptide-1. In 1970, procalcitonin was first classified by Leonard J. Deftos and Bernard Roos. It is produced by endocrine cells of the lung and by C cells of the thyroid. The level of procalcitonin rises in the human body due to injury, shock, or bacterial infection, which increases the production of procalcitonin, resulting in organ dysfunction. The level of procalcitonin in the body can be diagnosed with wet lab analysis using procalcitonin antibody.

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The global procalcitonin antibody market is expected to be driven by rise in prevalence of chronic diseases such as sepsis, hepatitis, tuberculosis, and HIV. According to the World Health Organization (WHO), cancer accounted for 8.8 million deaths and HIV related illnesses accounted for around 1.0 million deaths globally in 2015. Procalcitonin antibody is used as a marker to improve identification of bacterial infections and develop antibiotic therapies. This is expected to drive the procalcitonin antibody market. Moreover, increase in funding for research and development by major players and government initiatives for the development of safer, efficient, and innovative products for the treatment of diseases such as cancer boost the growth of the global procalcitonin antibody market. For instance, in 2018, the U.S. Government approved US$ 3 Bn fund for the National Institutes of Healths research and development activities.

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The global procalcitonin antibody market can be segmented based on antibody type, end-user, and region. In terms of antibody type, the global procalcitonin antibody market can be bifurcated into polyclonal procalcitonin antibody and monoclonal procalcitonin antibody. Based on end-user, the global procalcitonin antibody market can be classified into hospitals, research institutes, and others. In terms of region, the global procalcitonin antibody market can be segmented into North America, Europe, Latin America, Asia Pacific, and Middle East & Africa. Each region can be divided into specific countries/sub-regions such as the U.S., Canada, the U.K., Germany, Brazil, China, India, and GCC Countries. North America dominated the global procalcitonin antibody market in 2017 because of increase in adoption of new techniques in research and rise in health care spending. According to the U.S. Centers for Medicare & Medicaid Services, national health care spending is projected to increase at an average rate of 5.5% per year from 2017 to 2026 to reach around US$ 5.7 Trn by 2026. Asia Pacific is considered to be the most attractive market for procalcitonin antibody during the forecast period due to surge in health awareness and demand for advanced medical technology.

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Key players operating in the global procalcitonin antibody market are bioMrieux SA, HyTest Ltd., F. Hoffmann-La Roche Ltd., Shenzhen New Industries Biomedical Engineering Co., Ltd., Thermo Fisher Scientific, Vazyme Biotech Co., Ltd., Hotgen Biotech Co., Ltd., and Hangzhou Realy Tech Co., Ltd., among others. These players have adopted strategies such as collaborations, agreements, partnerships, and new product launches to gain competitive advantage in the procalcitonin antibody market.

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Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through ad hoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision.

ContactMr. Rohit BhiseyTransparency Market ResearchState Tower,90 State Street,Suite 700,Albany NY - 12207United StatesUSA - Canada Toll Free: 866-552-3453Email: sales@transparencymarketresearch.comWebsite: https://www.transparencymarketresearch.com/

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Procalcitonin Antibody Market: Innovative products for the treatment of diseases such as cancer boost the growth of the market - BioSpace

Hormone Refractory Breast Cancer Market 2021 | Extensive Growth | Opportunities | Impact and Precise Outlook 2029 AstraZeneca, AmpliMed Corporation,…

Hormone Refractory Breast Cancer Market Growth 20202027 is the latest updated report announced by Oneup Business Insights which is a complete research study on the market, which attempts to provide a clear picture of the key factors that shape this market.

It analyzes the industry of product kind, equipment type, price category (discount, mainstream, or premium, for example), distribution channel, by application and by geography and region. This market research contains an in-depth analysis of the industrys development potential and constraints. All of this data is presented in such a way that it adequately explains various facts and statistics to the business.

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Product Type Coverage

Chemotherapy

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Table of Contents: Hormone Refractory Breast Cancer Market:

Chapter 1: Overview of Hormone Refractory Breast Cancer Market

Chapter 2: Global Hormone Refractory Breast Cancer Market Status and Forecast by Regions

Chapter 3: Global Hormone Refractory Breast Cancer Market Status and Forecast by Types

Chapter 4: Global Hormone Refractory Breast Cancer Market Status and Forecast by Downstream Industry

Chapter 5: Hormone Refractory Breast Cancer Market Driving Factor Analysis

Chapter 6: Hormone Refractory Breast Cancer Market Competition Status by Major Manufacturers

Chapter 7: Major Manufacturers Introduction and Hormone Refractory Breast Cancer Market Data

Chapter 8: Upstream and Downstream Hormone Refractory Breast Cancer Market Analysis

Chapter 9: Cost and Gross Margin Analysis of Hormone Refractory Breast Cancer market

Chapter 10: Marketing Status Analysis of Hormone Refractory Breast Cancer market

Chapter 11: Hormone Refractory Breast Cancer Market Report Conclusion

Chapter 12: Hormone Refractory Breast Cancer Market Research Methodology and Reference

Research Objectives of this report:

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Hormone Refractory Breast Cancer Market 2021 | Extensive Growth | Opportunities | Impact and Precise Outlook 2029 AstraZeneca, AmpliMed Corporation,...

Hallelujah, the MLB announced there will be no sticky-substance checks at the All-Star Game, a game which literally does not matter – Golf Digest

Believe it or not, the MLBs All-Star weekend is less than two weeks away. Maybe youve been busy getting back to life, or maybe youve been distracted by baseballs Controversy Du Jour, which just so happens to be Sticky Substances. In mid-June, the MLB officially began in-game checks on pitchers for long-accepted substances used to help apply spin to the baseball and avoid career-altering injury in doing so. The midseason 180 has generated plenty of backlash from pitchers and fans alike, and has led to countless surprisingly creepy interruptions to your regularly scheduled baseball programming.

But we have spectacular news, anti-anti-stickies: This week the MLB made the HUGE announcement that it will take a ONE-NIGHT ONLY break from foreign-substance checks for the comprehensively meaningless All-Star Game. Wow. What can we say. We are truly blessed to be a part of such a wonderful sport run so wisely by the great and all-knowing Mr. Robert Manfred. Glory be!

Industrial-grade sarcasm aside, it really makes you wonder what the thought processif there is oneis here. At the height of the steroid era, the MLB didnt make the All-Star Game free HGH night. During the juiced ball era, they didnt give the Home Run Derby participants Superballs to hit. When it comes to watching Jacob DeGrom throw exactly two-thirds of an inning of consequenceless baseball, however, theyre relaxing their own hastily established rules in the name of, um, more strikeouts?

If that sounds dumb to you, thats because it is dumb. Welcome to baseball. Youre going to love it here.

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Hallelujah, the MLB announced there will be no sticky-substance checks at the All-Star Game, a game which literally does not matter - Golf Digest

The Extremely Selective Outrage Around Baseball Cheating – New York Magazine

Not every pitcher is thrilled about being checked constantly for foreign substances, as Max Scherzer illustrates. Photo: Rich Schultz/Getty Images

Last week, I was at Citi Field watching the Major League debut of Tylor Megill, a Mets non-prospect called up to the bigs to make a spot start because of the cavalcade of injuries afflicting the team (and MLB in general) this season. Megill pitched well not great, but good enough for the Mets to win and when manager Luis Rojas came to yank him from the game, he was met with appreciative and sustained applause from the Citi Field faithful. But then, suddenly, out of nowhere, the crowd began to boo lustily. Why? Because, as Megill left the field, two umpires stopped him and did the now-requisite checking of his hat and belt for foreign substances. Ever since June 21, when the MLB instituted its crackdown on sticky stuff the foreign substances that pitchers have used to gain an upper hand against hitters this has become a nightly occurrence at every ballpark in America. Home team pitcher leaves the field, umpires check him, fans boo the umpires. Its actually kind of fun.

I found the Megill episode particularly hilarious, considering his MLB debut came just two days after the new rules went into place; I cant imagine a dumber decision than a rookie putting Spider Tack on his hat for his debut, the very week rules were introduced to stop him from doing so. But I wonder what would have happened if the umps had found something on Megill. What if they cold busted him right there, ejecting him from the game and assuring hed be known as the guy nailed for using banned substances in his first-ever MLB game? I bet fans would have still booed the umps. I bet they would have booed them louder.

The new MLB initiative has led to a fresh round of recriminations for cheating players, with the league saying its trying to clean up the game and pitchers arguing its unfair to start banning things, midseason, that have been legal (or at least accepted) throughout the entirety of baseball history. (One pitcher, the Rays Tyler Glasnow, explicitly blamed the new rules for his arm injury.) Theres a whole debate to be had about the efficacy of the new rules; whether theyre less about cheating and more about trying to assign blame for a strikeout-heavy gameplay that many believe has ossified into something dull and repetitive;and whether its necessarily the best idea to antagonize half the players in the league just a few months before a potentially apocalyptic labor struggle. But I suspect the whole idea of cheating is a red herring here. Because I dont think fans care about cheating much at all.

Oh, sure, they claim they do. Baseballs last big scandal revolved around the Houston Astros and their infamous banging scheme, which allegedly helped them steal signs from opposing teams. Im on record as finding that whole thing rather silly and theres very little evidence that it even provided the Astros much of an advantage but it rocked the sport two years ago, and fans will be booing the Astros off the field for the next decade because of it. But its worth noting that Astros fans long ago moved on. The same is true of the Patriots SpyGate scandal in the NFL, or the Cardinals hacking scandal in MLB, or, uh, the Patriots Deflategate scandal. Fans of those teams have hardly turned on their franchises; they have circled the wagons to protect them. But fans in Boston, Houston, and St. Louis arent inherently less moral than anyone else, and its not like theyre predisposed to embrace cheaters however you want to define such a broad term any more or less. They just love their teams. Maybe the cheating troubles them; maybe they do care a little. But no matter what, they care about their team more. The act of winning is more important than how you get there.

The most illustrative example of this is MLBs steroid era. The collective wisdom is that when we look back at Barry Bonds, Mark McGwire, and Manny Ramirez (who actually retired rather than face punishment for his second positive PED test), we see villains. But those players fan bases dont. Bonds is still beloved in San Francisco, McGwire was recently elected to the Cardinals Hall of Fame, and there isnt a fan in Boston who doesnt get a smile on their face when Mannys name comes up. But its not just local fan bases. Fans often decided how angry they were about a players supposed cheating based on how much they liked the player in the first place. Alex Rodriguez was awkward, unpopular, and overpaid, so when he got caught up in the Biogenesis scandal, Yankees fans couldnt throw him overboard fast enough. But Andy Pettitte, who (unlike A-Rod or Bonds) actually admitted to his HGH usage, was quickly forgiven, with his I just tried it that once defense accepted at face value. Why? Because fans like Andy Pettitte. He may have been a cheater, but he was their cheater. Other examples in this vein include David Ortiz, Bartolo Colon, and Nelson Cruz; NFL examples include Julian Edelman, Will Fuller, and Mark Sanchez, who will be forever known more for his butt fumble than his 2018 PED suspension.

This is not to excuse cheating, though I will note that bending the rules has been an integral part of sports since there were sports, and the idea of some sort of level playing field has always been an illusion and a fallacy. (And its hardly something limited to professional leagues. I can confirm firsthand that cheating is extremely common in Little League baseball; playing by the rules is a great way to look, to other coaches and parents, like a goddamned sucker.) Its just that our standards for what counts as cheating, and how much moral outrage we gin up about it, are forever shifting. The only thing thats consistent is that we want our own teams to win. Wed rather them not cheat. But if theyre going to cheat, wed rather not know about it. Just dont get caught. As long as you win.

Do you think Yankees fans are really outraged over the moral turpitude of Gerrit Cole? The ace starter, who is signed to a contract that will pay him $36 million a year through the 2028 season, was specifically fingered as a sticky stuff suspect earlier this month. You may remember his response when asked about it. It was not reassuring.

Cole made his first start last Tuesday since MLB put in the ban on foreign substances, and while he was effective against a poor Kansas City team, it was obvious that his stuff, and his spin rate, was way down. He was quite clearly not the same pitcher.

In his next start, Sunday against the Red Sox, Cole got shelled, giving up five runs in five innings and allowing three homers. His pitches had less bite and movement than in any start over the last several years. Is he a different pitcher in an age of banned substances? Did the Yankees sign him for the next decade without considering that foreign substances were powering his rise?

It sure seems that way. But how do you feel about that? If you hate the Yankees, this is surely hilarious to you: Serves them right. But if youre a Yankees fan dont you wish he was still using the stuff? Wouldnt you like him to figure out a way to start again? Be honest.

Sports fans claim to dislike cheating. What they really mean is that they dislike when the other team does it. When their favorite player is the offender? Well, theyd rather just not hear about that. This isnt meant to be an indictment of sports fans. This well, this makes them just like everybody else.

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The Extremely Selective Outrage Around Baseball Cheating - New York Magazine

Prader-Willi Syndrome (PWS) Market: Increase in investment to find innovative solution for the PWS to drive the market – BioSpace

Prader-Wili syndrome (PWS) is a rare genetic disorder, which causes problems in intellectual development, behavior, physical growth, mood, and eating. This rare genetic disorder occurs due to changes in chromosome 15, which is responsible for regulating the gene expression. Difficulty to control eating is a major symptom among people with PWS. Other symptoms include moderate to high learning disabilities, possess a compulsive behavior, outbursts, and stubbornness.

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Newborns with this disorder may have small hands and feet, almond shaped eyes, and a triangular mouth. Other factors that define PWS included reduced development of genital organs, feeding difficulties, quick weight gain, uncontrollable overeating, and extremely weak muscles. The disorder also causes incomplete or delayed puberty among individuals of both sexes; therefore, they are unable to have children.

In many of the cases, the Prader-Wili syndrome is inherited. However, in some cases the anomaly can take place which can be caused due to malfunctioning of chromosome 15. This may be passed from one generation to the next, especially in maternal uniparental disomy and deletion in paternal chromosome 15. Genetic changes may occur randomly during the formation of reproductive cells or during early development of embryo. In such cases, affected people may or may not have a history of the disorder in their family.

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Prader-Willi Syndrome (PWS) Market Competitive Landscape

Chong Kun Dang Pharmaceutical Corp

Founded in 1941, Chong Kun Dang is headquartered in Seoul, South Korea. Company is leading pharmaceutical & biotechnological company in Korea. Company offers range of prescription drugs for anti-diabetics, anticancer, anti-hypertension, health supplements, prebiotics and healthy beverage products. Few of the drugs for Prader-Willi Syndrome (PWS) treatment are under pipeline. Chong Kun Dang Pharmaceutical Corp is the first Korean pharmaceutical company which has got U.S. FDA approval and which export some of the products to the U.S. market.

LG Life Sciences Ltd.

Founded in 2002, LG Life Sciences Ltd. is headquartered in Seoul, South Korea. The company specializes in specialty chemicals in South Korea and international market. Company also offers range of products in animal health products as well as pharmaceuticals. In pharmaceutical segment company offers treatment products for Prader-Wili syndrome, fertility treatment related products, hormones, viscosupplements used during the treatment of degenerative diseases, chemical vaccines etc.

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Prader-Willi Syndrome (PWS) Market Dynamics

Growth hormone continues to be the major constituent of overall therapeutic contribution:-

Currently, pharmacological drugs and therapy for Prader-Willi Syndrome are concentrated primarily on the usage of human growth hormone (HGH) supplementation, which is permitted in the U.S. Supplementation of growth hormone continues is one of the major constituent of overall therapeutic contribution of the market due to nearly pervasive deficiency of growth hormone (GH) in patients suffering from PWS syndrome. Accepted growth hormone therapies in North America and Europe include Genotropin by Pfizer, Nordotropin by Novo Nordisk, and Ominitrope (somatropin injection) from Sandoz. Growth hormone therapies which are increasingly used to treat PWS patients, especially older patients are central nervous system and cardiovascular agents.

Clinical Trials Pave the Way for PWS Treatments:-

Increase in investment to find innovative solution for the Prader-Willi syndrome (PWS) by pharmaceutical and biotech companies is expected to drive the market. Many clinical trials are taking place around the world which are helping to better understand syndrome and to develop novice products/ therapy for the treatment of PWS. However, side effects and high cost of these therapies are likely to hinder the global Prader-Willi syndrome market.

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Transparency Market Research is a next-generation market intelligence provider, offering fact-based solutions to business leaders, consultants, and strategy professionals.

Our reports are single-point solutions for businesses to grow, evolve, and mature. Our real-time data collection methods along with ability to track more than one million high growth niche products are aligned with your aims. The detailed and proprietary statistical models used by our analysts offer insights for making right decision in the shortest span of time. For organizations that require specific but comprehensive information we offer customized solutions through ad hoc reports. These requests are delivered with the perfect combination of right sense of fact-oriented problem solving methodologies and leveraging existing data repositories.

TMR believes that unison of solutions for clients-specific problems with right methodology of research is the key to help enterprises reach right decision.

ContactMr. Rohit BhiseyTransparency Market ResearchState Tower,90 State Street,Suite 700,Albany NY - 12207United StatesUSA - Canada Toll Free: 866-552-3453Email: sales@transparencymarketresearch.comWebsite: https://www.transparencymarketresearch.com/

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Prader-Willi Syndrome (PWS) Market: Increase in investment to find innovative solution for the PWS to drive the market - BioSpace

Understanding the Scope of ER+ Breast Cancer – Targeted Oncology

Sara Hurvitz, MD: Hello, Im Dr Sara Hurvitz, professor of medicine at the University of California Los Angeles, Johnson Comprehensive Cancer Center. Im going to be discussing today the AMEERA-5 clinical trial which is a randomized double-blind phase 3 clinical trial evaluating amcenestrant with palbociclib vs letrozole plus palbociclib for previously untreated hormone receptor-positive HER2-negative [human epidermal growth factor receptor 2] advanced breast cancer.

When you look at the scope of breast cancer and the different subtypes of breast cancer, it is notable that hormone receptor-positive breast cancer comprises the largest proportion of all cancers diagnosed. Hormone receptor-positive breast cancer represents about two-thirds to three-fourths of all breast cancers diagnosed. In terms of stage of disease, most patients in the Western world [receive a diagnosis at] stage I, II, or III breast cancer, only about 10% of patients at their initial diagnosis are diagnosed with advanced disease, meaning incurable stage IV metastatic breast cancer.

However, approximately 90% of patients who are diagnosed with early-stage disease, they are at risk for the rest of their life of being diagnosed with metastatic breast cancer or stage IV breast cancer. The risk of developing advanced stage disease goes up by the stage at which a patient is diagnosed. If a patient [received a diagnosis of] stage I breast cancer, she has a lower risk of developing advanced disease than somebody who is diagnosed, for example, with stage III breast cancer.

The prognosis of breast cancer, just focusing on stage IV breast cancer, is evolving over time as we have the availability of new agents come up. We do know, from some recent studies that are registry clinical trials and follow how long patients are living who are diagnosed with advanced disease, that the median overall survival is roughly on the order of 40 months or so for hormone receptor-positive breast cancer, HER2-negative advanced breast cancer. These data come from a French registry trial called ESME-MBC in which all women diagnosed starting around 2008 with metastatic breast cancer with subtype known were followed and assessed for median overall. Although we now have cyclin-dependent kinase 4/6 inhibitors available for the treatment of this disease, the median overall survival over this time course has not increased. Its possible that in the future we will see the median overall survival improve as more time has passed and the data mature.

Transcript edited for clarity.

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Understanding the Scope of ER+ Breast Cancer - Targeted Oncology

Best Supplements to Take Before Bed, According to Dietitians – Eat This, Not That

We all could use more/better/deeper sleep these days. And less stress? Sign us up. Enhanced muscle gains? Ditto. As you wind down for the day, you may want to consider these health-supportive and sleep-promoting supplements, say dietitians.

From melatonin to Ashwagandha, read on for the best research-backed supplements to take before bed. It goes without saying, but, before adding a new supplement to your routine, always consult with a trusted healthcare professional. Read on, and for more on how to eat healthy, don't miss 7 Healthiest Foods to Eat Right Now.

Let's get the most commonly recommended natural sleep supplement out of the way first. There's a good reason it's such a frequently advised remedy for sleep issues: "The body produces melatonin naturally, with levels dipping in the morning and rising in the evening to promote the body's sleep-wake cycles," says Kylie Ivanir, MS, RD, who runs a private practice called Within Nutrition. "Given melatonin's role in regulating the circadian rhythm and signaling the body it is time to sleep, supplements of this hormone can help facilitate the transition to sleep and promote consistent rest. This may be the case for individuals managing jet lag, insomnia, or wanting to improve sleep efficacy," she continues, pointing to this scientific overview.

READ MORE: Best Supplements for Sleep, According to Experts

Here's another heavy hitter in the world of sleep, which may also help with issues like anxiety.

"Magnesium comes in various formulations that can be beneficial in different ways. Magnesium citrate differs from the other chelated forms, such as magnesium bisglycinate and magnesium threonate, which are readily absorbed and work intracellularly," explains Ivanir. "Magnesium bisglycinate, in particular, can help with relaxation, sleep, and anxiety reduction. Therefore, it can be beneficial to take this form of magnesium at night before bedtime," she says, citing this study. You can also get magnesium from a variety of food sources like bananas, dark leafy greens, nuts, avocados, and beans.

Echoing Ivanir, Roxie M. Calloway, MS, RD says "[magnesium] is a natural relaxant and helps with sleep quality. Magnesium can also help relieve stress, as it can inhibit cortisol production and potentially lower blood pressure. She adds that men should have around 300 mg and women around 200 mg per day, though some people may opt to take more. "Magnesium has a lot of other health benefits as well. Magnesium is an essential mineral that plays a role in more than 300 different enzyme systems in the body. It helps the body use calcium and oxygen properly, and it helps build healthy bones and teeth," she further notes.

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"Passionflower has been used in alternative medicine for insomnia; yet, recent research has shown that passionflower may in fact impact your sleep quantity and quality. Sleep quantity refers to the total time you've spent sleeping, and sleep quality refers to how well you've slept," says Kim Rose, RDN, CDCES, CNSC, LD. "In order to achieve a good night's rest, the perfect balance of sleep quantity and quality must be met. A 2017 animal study showed that passionflower decreased wakefulness and showed a significant increase in the total time spent sleeping. As it related to sleep quality, one human study showed that passionflower tea was helpful. Though these studies are small, and more human research is needed before definitive claims can be made, passionflower may hold promising results for capping off your night," she elaborates.

This supplement may be a boon if you're looking for better sleep. "L-theanine is an amino acid mostly found in the green tea plant. A small 2016 study showed that L-theanine may have anti-stress benefits," explains Rose. "This is important because stress may also impact our sleep. Another study conducted in China showed that negative types of stress may promote sleep disturbance and disrupt overall sleep quality. For as much stress as modern-day society gives, L-theanine seems to be a smart choice."

Wrapping up for the night? If you're all about gym life, it might be a good idea to take a protein supplement before you hit the hay. "For active individuals, it can be beneficial to take a slowly digested protein supplement before bed. When utilized over a period of time in conjunction with strength training, pre-sleep protein can help increase muscle mass and strength, promote recovery, and improve performance," says Ivanir, referencing this research. "This may be due in part to the overnight spike in growth hormone, which helps synthesize muscle mass."

Calloway zooms in on casein protein (from eggs) as the best type: "It's a good idea to consume casein protein before bedtime to promote muscle growth due to its slow digestion. Casein, unlike whey, is a very thick protein that breaks down slowly in the stomach and helps give your muscles nutrients (while promoting growth hormone secretion) while you're asleep," says Calloway. "It's a complete protein with all essential amino acids and has been shown to increase lean muscle mass. When this protein is consumed just before going to bed, it helps promote muscle protein synthesis while allowing your muscles to recover from workouts overnight."

It may very well be time to befriend this Ayurvedic herb with a large slew of applications.

"It is specifically known to produce a calming effect, which may be beneficial to sleep. While most studies on ashwagandha have been done on animals, one notable human study demonstrated that ashwagandha may very well improve sleep," says Rose. "In order to sleep well, you have to have a sense of calm. In this particular study, it was shown that ashwagandha did just that and improved sleep quality while decreasing the amount of time it takes to go from being fully awake to sleeping."

Hopping aboard the CBD train may have a positive impact on your sleep. "One sleep-promoting supplement I would recommend is cannabidiol or CBD. CBD, one of the main cannabinoids in the cannabis plant, interacts with the endocannabinoid system which helps regulate many processes in the body," says Ivanir. "While difficulty sleeping may be due to a variety of reasons, if it is caused by factors such as anxiety CBD may be beneficial. Research shows that CBD can have a calming effect, which can help reduce stress and improve sleep quality. Furthermore, if chronic pain is interrupting sleep, CBD has also been shown to help relieve pain and thereby aid in sleep. CBD may also interact with receptors in the brain that govern sleep-wake cycles, promoting sleep directly," she continues.

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Best Supplements to Take Before Bed, According to Dietitians - Eat This, Not That

What Happened to Jason Giambi and Where is He Now? – Fanbuzz

Former New York Yankees slugger Jason Giambi is one of baseballs all-time greatest hitters. He played 20 years in MLB and won a multitude of awards throughout his career.

Still, Giambi filled his time in The Show with controversy, including the performance-enhancing drugs scandal that rocked Major League Baseball in the mid-2000s.

Giambi retired from professional baseball at the age of 43, but what is the former first baseman doing now?

RELATED: Mark McGwire Cheated. What Happened to Him After Baseball?

Jason Giambi was born in West Covina, California, and attended South Hills High School. He has a brother, Jeremy Giambi, who also played in MLB.

Jason Giambi played college baseball at California State University at Long Beach before being drafted as a second-round pick by the Oakland Athletics in 1992.

Giambi played his first MLB game in 1995 against the Texas Rangers. After that, he spent the first seven years of his career in the Bay Area and put up some monster numbers for Oakland.

In 2000, Giambi was named the American League MVP after hitting 44 home runs with 137 RBIs. That year, Giambino made his first All-Star Game while leading the league in walks and on-base percentage.

After another dominant campaign in 2001, and a second-consecutive playoff defeat at the hands of the Yankees, Giambi left the small-market team in Oakland. He was a hot commodity as a free agent, having just led the league in slugging percentage.

So the New York Yankees signed Giambi to spend the next seven seasons at first base and as a designated hitter in the Bronx at Yankee Stadium under manager Joe Torre.

Giambi got off to a hot start in pinstripes, stringing together back-to-back 41-home run seasons and eclipsing the 100-RBI threshold.

In 2003, Giambi logged a .250 batting average and launched 41 bombs to help lead the Yankees to the World Series. The team fell short of its goal, unfortunately, in a tough loss to the Florida Marlins.

Giambi left the Yankees in 2008 as a 37-year-old and returned to the Athletics. He was cut midway through the 2009 season and subsequently signed with the Colorado Rockies.

He played for the Rockies from 2009-12 before finishing his career with the Cleveland Indians.

Giambi retired after the 2014 season as a five-time All-Star, one-time AL MVP, and two-time Silver Slugger. He featured in 2,260 regular-season games and 45 postseason games throughout his career.

While Jason Giambis career was filled with terrific seasons and many home runs, there was also quite a bit of controversy surrounding the baseball player.

Giambi was one of the MLB players at the forefront of the BALCO Scandal, which outed players who had proven to be using illegal human growth hormones and other performance-enhancing drugs.

Giambi came clean and admitted to using banned substances at a 2003 grand jury hearing. Among various other transcripts, that testimony was obtained by the San Francisco Chronicle and released to the public.

In 2007, Giambi issued an apology for his involvement and participation in the PED scandal. While he was initially scrutinized heavily for his actions, he found that issuing a heartfelt apology resulted in him earning forgiveness from those across the league.

Giambi, among others like Alex Rodriguez, Barry Bonds, and Mark McGwire, all came under intense scrutiny for their use of HGH throughout their careers, and its played a significant factor in keeping some star players out of the Hall of Fame.

These days, Jason Giambi resides in Henderson, Nevada near Las Vegas with his wife Kristian. The couple has three children together: two daughters and a son named Tristan.

Tristan Giambi has started Little League, and Jason told MLB.coms Alfred Santasiere III how he became the coach of his sons team. While Giambi expressed his interest in returning to baseball in a coaching role, it seems his top priority as of now is his family.

The last weve heard from Giambi was his response to the Houston Astros sign-stealing scandal, to which he stated that the Astros antics were similar to PED use and that teams will always be seeking out ways to gain a competitive advantage.

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What Happened to Jason Giambi and Where is He Now? - Fanbuzz

Human Growth Hormone Market by Technology, Solutions, Application, Price, Demand Analysis and Growth Opportunities to 2025 – Express Journal

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Human Growth Hormone Market by Technology, Solutions, Application, Price, Demand Analysis and Growth Opportunities to 2025 - Express Journal