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Short Bowel Syndrome Market Research Report by Drug Class (GLP-2, Glutamine, and Growth Hormone), by Region (Americas, Asia-Pacific, and Europe, Middle East & Africa) - Global Forecast to 2026 - Cumulative Impact of COVID-19

New York, July 19, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Short Bowel Syndrome Market Research Report by Drug Class, by Region - Global Forecast to 2026 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p06087677/?utm_source=GNW

The Global Short Bowel Syndrome Market size was estimated at USD 864.06 Million in 2020 and expected to reach USD 1,026.86 Million in 2021, at a Compound Annual Growth Rate (CAGR) 19.18% from 2020 to 2026 to reach USD 2,476.11 Million by 2026.

Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR GBP, JPY, and AUD. It helps organization leaders make better decisions when currency exchange data is readily available. In this report, the years 2018 and 2019 are considered historical years, 2020 as the base year, 2021 as the estimated year, and years from 2022 to 2026 are considered the forecast period.

Market Segmentation & Coverage:This research report categorizes the Short Bowel Syndrome to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Drug Class, the Short Bowel Syndrome Market was studied across GLP-2, Glutamine, and Growth Hormone.

Based on Geography, the Short Bowel Syndrome Market was studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas is further studied across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific is further studied across China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa is further studied across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, and the long-term effects are projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlying COVID-19 issues and potential paths forward. The report delivers insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecasts, considering the COVID-19 impact on the market.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies to help the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. It describes the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth during a forecast period.

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Short Bowel Syndrome Market based on Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Market Share Analysis:The Market Share Analysis offers the analysis of vendors considering their contribution to the overall market. It provides the idea of its revenue generation into the overall market compared to other vendors in the space. It provides insights into how vendors are performing in terms of revenue generation and customer base compared to others. Knowing market share offers an idea of the size and competitiveness of the vendors for the base year. It reveals the market characteristics in terms of accumulation, fragmentation, dominance, and amalgamation traits.

Company Usability Profiles:The report profoundly explores the recent significant developments by the leading vendors and innovation profiles in the Global Short Bowel Syndrome Market, including 9 Meters Biopharma, Inc., Adocia SAS, Ardelyx Inc, AstraZeneca PLC, Emmaus Life Sciences, Inc., Johnson & Johnson Services, Inc., Merck KGaA, Mylan N.V., Naia Pharmaceuticals, Inc., Nestl S.A.,, Novartis International AG, Nutrinia Ltd, OPKO Health Inc., OxThera AB, Pfizer Inc., PhaseBio Pharmaceuticals Inc., Sancilio & Company Inc, Shire PLC, Swedish Orphan Biovitrum AB, Teva Pharmaceutical Industries Ltd, VectivBio AG, and Zealand Pharma A/S.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyze penetration across mature segments of the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, certification, regulatory approvals, patent landscape, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and breakthrough product developments

The report answers questions such as:1. What is the market size and forecast of the Global Short Bowel Syndrome Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Short Bowel Syndrome Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Short Bowel Syndrome Market?4. What is the competitive strategic window for opportunities in the Global Short Bowel Syndrome Market?5. What are the technology trends and regulatory frameworks in the Global Short Bowel Syndrome Market?6. What is the market share of the leading vendors in the Global Short Bowel Syndrome Market?7. What modes and strategic moves are considered suitable for entering the Global Short Bowel Syndrome Market?Read the full report: https://www.reportlinker.com/p06087677/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Short Bowel Syndrome Market Research Report by Drug Class, by Region - Global Forecast to 2026 - Cumulative Impact of COVID-19 - Yahoo Finance

Andrew & Everett,aleadingnaturalcheese brand,revolutionized the clean cheese industry over 20 years ago byintroducingthe firstrBGH-BST hormone-free cheese in the U.S.,raising the bar on the industry standard.Andrew & EverettAmerican CheeseistheonlyAmerican Cheese sliced fresh from the delitogain national acclaimfromWhole FoodsMarket,meeting the highest standards of any American Cheese.

The full line ofAndrew & Everettpre-sliced cheesesincludesYellow and White American,Swiss, Mild Cheddar, Mozzarella, Pepper Jack, Colby Jack, Havarti, Muenster,andProvolone. They are creamy,delicious,andperfectfor melting on burgersandwonderfuladditions tosnacks and sandwichesat yoursummerpicnics.

Theirline ofAmerican Cheeseparticularly stands out against other brands, asAndrew & Everett AmericanCheeseismade with natural aged Cheddar and aged Monterey Jack cheese, not leftover ends, or pieces. It has no artificial preservatives, colors, no sugars added, no soy or soy lecithin, no whey or whey protein concentrates, no milk protein concentrates or calcium phosphates, and isrBGH-BST hormone free.

AtAndrew & Everett,we believethat cheese should tasteamazingjust the way it is.Thatiswhywestart with thehighestquality milkfromgrass-fed cowsthat areraisedhumanely on family-ownedfourth generationfarmsthroughout Americas Heartland,says Kevin Rider, Senior Brand Manager ofAndrew & Everett.This produces a delicious, creamier tasting cheese thats free fromartificialhormones and preservatives and only has recognizable ingredients you can pronounce,adds Rider.

The cheesemakers atAndrew & Everetttake anauthentic approach to cheesemaking, turning milk to cheese in 48 hours by master artisan cheesemakers local to where the cowsareraised. This special process is essentialinproducing a fresher, creamier, better tasting cheesewithout anyadditives or flavor enhancers.Andrew & Everettsexceptionalflavoristhe result of anunwavering effort to create a truly clean label natural,preservative andartificialhormone-free cheese that tasteslike it comes straight fromyour local farmer.

Joining thealready vastnatural cheeseline-up,Andrew & Everettintroduces NEWAndrew & EverettRustic Thick Cut Shredded Cheese,a larger cut shredthat isgreat for melting and maintains its flavor and cheesy texture when heated.It is available inSharp WhiteCheddar, Mozzarella, and Fiesta Blend varieties.

The complete line ofAndrew & EverettCheeses beyond thepre-sliced line includes:

We have one of the broadest offerings of natural, preservativefreeandartificial hormone- freecheeses that not only meets consumer needs for better-for-you, clean label cheese, but tastes exceptionally flavorful, never compromising on qualityorflavor says Kevin Rider.Hands down Andrew & Everett has the BEST AmericanCheese, adds Rider.

To inspireyour summergrilling, try this Philly Grilled Steak and Cheese Sandwich

INGREDIENTS

PREPARATION

Serving 1

For anamazingsummerappetizer,trythisAmericanCheeseCon QuesoDip:

INGREDIENTS

PREPARATION

Serving 6-8

About Andrew & Everett

Andrew & Everettcheeses offer natural, clean label, preservative andhormone-free products from grass-fed cowsraised onsmall,fourthgenerationfamily-owned farmsin the heartland of America. Each farm has around only 15 heads of cattle, allowing for smaller batches of cheese that are all produced from the first run of the day, to ensure no cross-contamination and the cleanest cheese possible. The farm-to-tablefreshness is also ensured, as the milk is made into cheese within 48 hours by master and artisan cheese makers. Their productsare made with vegetarian rennet,contain no antibiotics,artificialhormones,artificialpreservatives, artificial colors,binders,or fillers, and are gluten-free. No cows are injected with syntheticrBGH-BST growth hormones or fed animal by-products. No antibiotics are used for any of their cows, so if cows become ill and antibiotics are necessary, they are removed from the dairy herd and their milk is used for conventional cheese. AllAndrew & Everettproducts are produced in gluten-free facilities and tested on a regular basis to ensure the non-presence of glutens.Andrew & Everettcheeses are the only American variety of cheeses sold at Whole Foods, meeting the highest standards.

Their national distributioncoversanextensivelist ofnationalfirst-ratenatural/specialtyretailers and exceptional standards of ingredients and production placeAndrew & Everettin thetop tierofassisting consumers in making clear, informed decisions about the healthy foods they choose.

For more information, please visithttps://andrewandeverett.com/

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New Cheese Products and New Recipes from Andrew & Everett - Food & Beverage Magazine - Food & Beverage Magazine

Evolve business intelligence, today has published a new market research report on The global Growth Hormone Deficiency market size was valued at $3.13 Billion in 2020 and is expected to reach $5.80 Million by 2028 growing at the CAGR of 7.99% from 2021 to 2028.

For more information on the report: https://report.evolvebi.com/index.php/sample/request?referer=murphyshockeylaw.net&reportCode=002042

The COVID-19 pandemic has led to disruption in the supply chain leading to lower demand or supply shortages in the growth hormone deficiency market. The travel restrictions and social-distancing measures have resulted in a sharp drop in consumer and business spending and this pattern is expected to continue for some time. The end-user trend and preferences have changed due to the pandemic and have resulted in manufacturers, developers, and service providers adopting various strategies to stabilize the company.

In terms of COVID 19 impact, the growth hormone deficiency market report also includes the following data points:

The recent COVID scenario is expected to have a positive impact on the growth hormone deficiency market. Due to the increasing spread of Coronavirus, several companies are working with a limited workforce leading to delays in work/production. This has impacted the market in the years 2020 and 2021.

Competitive ScenarioSome of the major growth hormone deficiency players holding high market share include Novo Nordisk A/S, Pfizer Inc, Novartis AG, Anhui Anke Biotechnology (Group) Co., Ltd. These players use new product development, partnership, and acquisition as key strategies to gain significant market share to compete with market leaders.

Segmental AnalysisThe growth Hormone Deficiency market is analyzed across the below-mentioned different segments:

Report CoverageThe study also contains a comprehensive value chain, as well as details on the key factors affecting the market growth (drivers, constraints, and opportunities). Furthermore, the report includes 10 key players in the growth hormone deficiency market ecosystem that have been strategically profiled, along with the market ranking/share for major players. Under the company profile section, the companys core competencies have been comprehensively analyzed, along with detailing the competitive landscape for the market players, and the strategies such as partnerships and collaboration, acquisitions, product launches and developments, contracts, and business expansion adopted by them to grow in the market.

The key players profiled in the report are:

To request a free sample report https://report.evolvebi.com/index.php/sample/request?referer=murphyshockeylaw.net&reportCode=002042

Research MethodologyThis research study makes substantial use of secondary sources, archives, and databases (such as annual reports, news releases, magazines, Trademap, company websites, and other paid databases) to classify and gather information valuable for this analysis. The entire process involves a review of top industry participants financial records. Following the determination of the overall market size, the total market was divided into several segments and sub-segments, and this information was then verified through key industry specialists such as CEOs, directors, VPs, and marketing executives.

Report Objectives

About EvolveBIEvolve Business Intelligence is market research, business intelligence, and advisory firm providing innovative solutions to challenging pain points of a business. Our market research reports include data useful to micro, small, medium, and large-scale enterprises. We provide solutions ranging from mere data collection to business advisory.

Evolve Business Intelligence is built on account of technology advancement providing highly accurate data through our in-house AI-modelled data analysis and forecast tool EvolveBI. This tool tracks real-time data including, quarter performance, annual performance, and recent developments from fortunes global 2000 companies.

AddressEvolve Business IntelligenceC-218, 2nd floor, M-CubeNH 48, Balitha, VapiGujarat 396191India

Contact: +1 773 644 5507 / +91 635 396 3987Email: [emailprotected]Website: https://evolvebi.com/

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Growth Hormone Deficiency Market is expected to reach $5.80 Million by 2028: COVID Impact, Opportunities, Trends and Forecast Murphy's Hockey Law -...

Whats Jeep, and when did it start making cars?

Jeep is an American manufacturer of 4x4s and SUVs, as well as a source of subtly branded clothing to illustrate your affinity for all things off-road and Murican. Or at least your affinity for cut-price clothing bins.

Jeeps start date is officially 1943, when the trademark application was first lodged. But then the company claims it kicked off in 1941. Um. Right.

Really, Jeeps birthday (and etymology) is fuzzier than the three-day growth of the GIs who drove them. Was it March 1941, the anything goes era where prototypes and pre-production models got the nod and were press-ganged into duty? Was it July 1941, when full production started? Or maybe April 1942, when that same army was awarded the patent for its design, despite the fact that it was the work of Willys, Ford, and Bantam? And how did we get the name Jeep in the first place?

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Its probably easiest to just say the 40s and great question before changing the subject. Theres an idea that Jeep comes from the Ford GPW, much like the Humvee came from HMMWV, but another idea that it comes from an old Popeye character called Eugene the Jeep. But did you really come here for a history lesson?

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And that, kids, is how you change the subject.

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Mostly in America, as youd expect. Given its iconic status and proclivity for a bit of parochial pride, Jeeps tend to be built in the US of A, generally in towns that wouldnt look too out of place in the opening half of The Deer Hunter. Of course, theres a plant in Mexicoa company cant be truly American until its outsourced something to its southern cousinsand apparently a total of 10 plants across six countries, including the US and Mexico.

Jeep has also had factories in roughly every country a sixth-grader could point to on a map, and unlicensed copies of its most famous vehicle have cropped up across Asia as well as in Europe and the Americas. Well-traveled, you might say.

In terms of sales, you can generally expect between one million and 1.8 million sales a year. Which, presumably, means about the same number of cars built in the same period. Recent hits to supply chains, microchips, and so on are sure to have hurt things (and put a severe dampener on plans to double Jeep sales by 2023), but it keeps trucking along, as it were.

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PHOTO BY TopGear.com

No cars, if were being pedantic. Thats kind of what the last line of the last paragraph was alluding to: Jeep builds trucks. Not, like, truck trucksthats the preserve of Ram, which is like if Chevrolet created an entire brand to sell commercial vehicles. Ram, like Jeep, is under the Stellantis umbrella, which is the new, larger umbrella made by stitching the Fiat-Chrysler umbrella to the Peugeot-Citroen umbrella and hoping nothing leaks. But we digress.

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Jeep is known for the Wrangler, an off-roader that rides on a truck-ready ladder frame. It also makes the Gladiator, a pickup truck based on the Wrangler off-roader that rides on a truck-ready ladder frame. Simple.

There are also SUVs that should really not be called the Cherokee and the Grand Cherokee anymore, surely. In any case, they break the mold by having unitary bodies, like youd find in a car, but a lot more ground clearance than youd find in a normal car.

The Wagoneer is making a comeback after three decades as a full-size SUV, which is Americanese for a vehicle the size of a mining truck. It used to beyou guessed ita ladder-frame-based heffalump, but will join the rest of us in the Anthropocene and offer a unitary body this time around. Just kiddingits going on the same ladder frame that underpins the Ram 1500 pickup. Mm. Refined.

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Then there are the little SUVs and crossovers that try their damndest to be a real Jeep, with all the Jeep badging and jingoistic names like Patriot and Renegade. Honestly, theyre interchangeable enough that you might not even notice one of those weve just mentioned hasnt been on sale for years. The Renegade, on the other hand, might be the best combination of ironic and adorable weve ever encountered. Look at that little face! It may as well come as standard with a sticker that says, When I grow up, Im going to be a Wrangler.

PHOTO BY TopGear.com

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The cheapest is going to be the little Renegade, rolling all the way up to the big daddy Grand Wagoneerthat is, if the Wagoneer is coming to your neck of the woods. Otherwise, its going to be the Grand Cherokee L, a three-row SUV with a slightly smaller unitary body.

PHOTO BY TopGear.com

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Well, its definitely going to have Trackhawk in the name there somewhere, given that its how Jeep denotes its Hemi-powered Lance missiles. In particular, its the Grand Cherokee Trackhawk, replete with a 700hp supercharged V8, a 0-100 sprint in the low-threes, and a claimed top speed of 290kph. So, quick enough, no?

PHOTO BY Bahnfrend

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Were going with the jeepney. For those of you who havent been to the Philippines, the jeepney is the kind of vehicle thatd make MacGyver tumescent.

Jeepneys started life as surplus Army Jeeps, left behind after the Americans kicked the Imperial Japanese out of the Philippines toward the end of World War II. But because the Japaneseand some pretty serious American shellinghad destroyed pretty much everything, including fleets of taxi-share cars, Filipinos got creative.

Simple Army Jeeps were reborn as proper passenger buses, operating as cheap share-taxis and getting the Philippines moving again. Decades later, the ornately decorated, MacGyvered-together buses are still the cheapest way to get around Manila. Jeepneys are, to all intents and purposes, a cultural icon, like Londons double-decker buses or the canary-yellow cabs of New York. Okay, theyre about as safe and environment-friendly as a fracking rigwhich is a big part of why theyre being forced out in favor of safer, cleaner transportbut after more than seven decades of faithful service, theyve probably earned their keep. And, were sure, would continue to do so for decades yet.

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Really, the victory is more Filipino than American, but for creating a vehicle with such incredible ruggedness, simplicity, and utility, well still hand a best moment nod to Jeep.

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Easy one, this: the Jeep Commander. So bad, even the boss hated it. The late Sergio Marchionne was reported to have said it was unfit for human consumption, and that despite selling some, I dont know why people bought them.

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Oof.

PHOTO BY TopGear.com

Lets make this answer multiple-choice, no? Because thats definitely how answers work.

For some, it might be spinning an entire car company, ethos, and mythos off a simple wartime conveyance. For others, it could be the sheer number of companies whove owned Jeep since its inception in the 40sfirst Willys, then Kaiser, AMC (with a bit of Renault input), then Chrysler in three different guises (Chrysler, Daimler-Chrysler, then Fiat-Chrysler), before settling in under the vast agglomeration that is Stellantis.

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Or, of course, it could be that time Jeep launched the then-new Grand Cherokee by driving it through a plate glass window.

PHOTO BY TopGear.com

Jeep, especially recently, has done some staggeringly good concept cars, from best-of restomods to insane, barrel-chested off-road monsters that should run on human growth hormone, not gasoline. And they take them all out to Moab every Easter to use them as Our Lady of Blessed Acceleration intended. None of this careful, its just a concept car nonsense; these are proper things that work properly.

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Our favorite, unequivocally, is the Wagoneer Roadtrip concept. We like it so much, in fact, that weve already written a story about it.

PHOTO BY TopGear.com

When someone from Jeep says that one of its vehicles is an icon, itd be fairly easy to dismiss it as regular-strength American braggadocio and move on with our lives. But when theyre talking about something thats not only the most iconic vehicle from historys greatest conflict, but also a bona fide design icon, it might actually be time to pay attention.

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In fact, the Jeep M38A1 is the only American vehicle on display in Manhattans Museum of Modern Art, in among an ultra-rare Cisitalia 202, an E-Type roadster, a Citroen DS, a first-gen Porsche 911, and the prettiest Formula 1 car of our generation, the Ferrari 641. Not a bad effort for one of the most utilitarian vehicles ever created.

NOTE: This article first appeared on TopGear.com. Minor edits have been made.

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The Hormone Replacement Therapy Market research report provides an analysis of major manufacturers, geographic regions, and provides advanced information about the major challenges that will affect market growth. The report includes definition, classification, application and industrial chain structure, development trend, analysis of the competitive landscape, and analysis of distributors in key regions. The report also provides supply and demand data, revenue, and share.

The report provides in-depth knowledge about the utilization and adoption of the Hormone Replacement Therapy industry in various applications, types, and regions/countries. In addition, the main stakeholders can identify the main trends, investments, driving factors, initiatives of vertical players, the governments pursuit of product acceptance in the next few years, and insights into the commercial products that exist in the market.

According to the report, the market is appropriately divided into important segments.

Segmentation by Compitetion

The competitive landscape of the global Hormone Replacement Therapy market is fragmented. The emergence of a large number of key players is the main reason for such fragmentation in the global market. In the next few years of the forecast period, global market competition is expected to only intensify. The market leader like F. Hoffmann-La Roche, Merck Serono, Novartis, Novo Nordisk, Pfizer, Abbott Laboratories, ANI Pharmaceuticals, Bayer, Eli Lilly, Hisamitsu Pharmaceutical, Merck, Mylan Laboratories, has invested a lot of money in research and development activities.

Segmentation by Region

The global Hormone Replacement Therapy market has five main regional segments, divided by geographic region. These regions are North America, Europe, Asia Pacific, Middle East-Africa, and Latin America.

Segmentation by Type

Estrogen replacement therapy, Growth hormone replacement therapy,

Segmentation by Application

Oral, Parenteral, Transdermal,

Impact of COVID-19:

The industry is mainly driven by increasing financial incentives and regulatory support from governments around the world. The current Hormone Replacement Therapy market is mainly affected by the COVID-19 pandemic. Hormone Replacement Therapy Market document looks into the impact of Coronavirus (COVID-19). Since December 2019, the COVID-19 contamination spread to nearly 180+ countries around the sector with the World Health Organization pronouncing it a popular well-being crisis. The worldwide consequences of the Covid contamination 2020 (COVID-19) are actually starting to be felt, and could basically have an effect on the Hormone Replacement Therapy market in 2021. Most projects in China, the United States, Germany, and South Korea have been postponed. These companies are facing short-term operational problems due to supply chain constraints and the inaccessibility of factories due to the COVID-19 outbreak. Due to the pandemic impact in China, Japan, and India, the spread of COVID-19 is expected to severely affect the Asia-Pacific region.

Frequently Asked Questions

What does the report cover?The report incorporates an analysis of factors that promote market growth. The report introduces the competitive landscape of the global market. This also provides a range of different market segments and applications that may affect the market in the future. The analysis is based on current market trends and historical growth data. It includes detailed market segmentation, regional analysis, and industry competition pattern.

Does the report estimate the current market size?The report effectively assesses the current market size and provides industry forecasts. The value of this market in 2019 is $XXX million, and the compound annual growth rate during 2021-2027 is expected to be XX%. (*Note: XX values will be given in final report)

How does the report provide the market size of the market?The report effectively assesses the current market size and provides forecasts for the industry in the form of Value (millions USD) and transaction Volume (Thousands Units)

What market dynamics does this report cover?The report shares key insights on:

It helps companies make strategic decisions.

Does this report provide customization?Customization helps organizations gain insight into specific market segments and areas of interest. Therefore, WMR provides customized report information according to business needs for strategic calls.

Hormone Replacement Therapy Market 2021-2027: Main Highlights

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Mr. ShahWorldwide Market Reports,Tel: U.S. +1-415-871-0703 / U.K. +44-203-289-4040 / Japan +81-50-5539-1737Email: sales@worldwidemarketreports.com

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Hormone Replacement Therapy Market Covid 19 Overview: Demand Analysis and Growth Opportunities by 2027: F. Hoffmann-La Roche, Merck Serono, Novartis,...

Peter Salgo, MD: Lets talk about patient factors. We alluded to it, but lets make it a bit more concrete. What are the patient factors that you consider when youre talking about the injectable treatment vs the nasal spray? Lets take the red kit out for now because Im getting a sense none of you guys really likes that very much, but it was all you had for a while. Lets look at these 2 new therapies: the injectable and the intranasal. Are there some patients who are better off with 1 rather than the other? If they like 1 or the other, can you switch from 1 class of therapy to another? Elaine?

Elaine Apperson, MD: Absolutely. You could definitely switch, but were not really talking about a patient but whos going to be administering it. I dont know that patient factors really matter as much as looking around and seeing who might be attending to that person is: spouse, nursing aide, coach, roommate, or teacher.

Peter Salgo, MD: I shouldnt have said patients. I should have said sociologic factors because thats the whole environment, right? Its the whole ecosphere.

Elaine Apperson, MD: What Davida said was also really important: insurance coverage, at the end of the day, is going to make a difference too. It makes a big difference for all of us. Look, we dont get too picky around basal and bolus insulin. We usually just go by what the insurance tells us to prescribe. Thats often the way medicine works these days. We say, We are going to use growth hormone, so we must look at the insurance. Were going to use this or that or the other. We are going to look at the insurance first. Its part of being an endocrinologist. Its really all the same in the end. Its the brand we use or what the insurance tells us to use. Unfortunately, that extends to glucagon products. Luckily, as Davida also mentioned, usually 1 or the other is covered.

Peter Salgo, MD: Is it fair to say, from what Im hearing, that its in the do not care mode? They both work; theyre both efficacious. If insurance covers 1, just buy that 1. If insurance covers the other 1, buy that?

Elaine Apperson, MD: Personally, the form factor is important: the prefilled syringe and the pen-like device is more familiar to patients with diabetes than the intranasal and injection. I have children who havent received the full dose of the intranasal glucagon when theyre seizing because theyre hard to control.

Peter Salgo, MD: In other words, its what you pointed out before. If a kid is writhing or moving around, its tough to put something in that kids nose and get the whole dose in there.

Elaine Apperson, MD: You put it in, and they suddenly jerk, and you dont know if theyve got it and youve already used 1 Baqsimi a month ago. Then what do you do?

Peter Salgo, MD: I hear what youre saying. You like the SC [subcutaneous] version better.

Elaine Apperson, MD: I do.

Peter Salgo, MD: Can we take a vote? Who likes what? Why dont we go around the horn a little. Davida, what do you like?

Davida Kruger, MSN, APN-BC, BC-ADM: I agree. I tend to like the prefilled forms of this, only because it reminds people of an EpiPen. Its easier to find a body part to be able to put it in vs having to get it in the nose.

Peter Salgo, MD: Im sorry, you just reminded mepick a body part, any body part. But it makes sense

Elaine Apperson, MD: I heard that it hurts, that the intranasal spray really hurts. One family used it a little prematurely, and the patient wasnt truly unresponsive yet, so they said it was the most painful.

Peter Salgo, MD: Really? We didnt discuss thisthe intranasal hurts?

Elaine Apperson, MD: Well, anecdotally.

Davida Kruger, MSN, APN-BC, BC-ADM: I havent heard that, but most of my patients are unconscious when I get it, so Im not sure that counts.

Elaine Apperson, MD: This poor child wasnt quite unconscious yet, and it hurt.

Davida Kruger, MSN, APN-BC, BC-ADM: Patients and family members are just grateful for using either of those as opposed to the panic when they open the red box and say, Now what do I do? Thats when the 911 call usually happens.

Peter Salgo, MD: Anne, what do you vote for?

Anne Peters, MD: My patients caregivers or family members generally prefer the intranasal glucagon because theyre used to putting nasal spray in because their sinuses are bad or whatever. Thats something they relate to. I dont have that many family members who are used to giving epinephrine, so they tend to prefer the intranasal method. But its not about me; its about them.

Davida Kruger, MSN, APN-BC, BC-ADM: Yeah.

Anne Peters, MD: I offer it, and I have samples. I ask, Which 1 do you want? We also talk about insurance coverage, but if the world were neutral, its simply what a family member wants.

Davida Kruger, MSN, APN-BC, BC-ADM: Absolutely.

Anne Peters, MD: Ive shown people both, and they take whatever they want because its about using it. Ive had patients give it to themselvesthe intranasal stuffand they say it feels like a bullet to the brain. You dont want a conscious person using glucagon intranasally because its a very strong drug and a very strong push-up. But its working. Its really spraying that stuff in the back of your nose. Dont use it for conscious patients. Thats not a good thing.

Peter Salgo, MD: My thought is that after everybody has had a year of having tongs put up their noses for COVID-19 tests, we could all be desensitized to this. Jay, what do you think?

Jay Shubrook, DO, FACOFP, FAAFP, BC-ADM: Im agnostic. I feel like its whatever youre going to fill, whatever the family is comfortable givingthats what Im going to write. Because I treat both adults and kids, its all over the map in terms of the response. I need them to have confidence that they can give it, that they can afford it, and that they will fill it. Ill use any of them because when used properly, they can all work.

Peter Salgo, MD: I want to thank all of you at home for watching this HCPLive Peer Exchange. If you enjoyed the content, I want you to subscribe to our e-newsletter to receive upcoming Peer Exchanges and other great content right in your in-box.

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Selecting or Switching Formulations of Glucagon - MD Magazine

The majority of women undergoing in vitro fertilization (IVF) are opting to pay for add-ons treatments despite limited evidence surrounding their effectiveness.

Research presented last week at the annual meeting of the European Society of Human Reproduction and Embryology reported that 82 percent of the women in the study used IVF add-ons.

The study focused on a cohort of Australian women, but the researchers say the number of women using IVF add-ons could be even higher in countries such as the United States where IVF is often privately funded.

It has been suggested that IVF add-on use might be more common in areas where IVF is largely provided by private companies rather than through public clinics. In Australia, IVF is largely provided by private companies and this is similar to the situation in the U.S. So, it is likely that IVF add-on use may be widespread in the U.S., too, Sarah Lensen, PhD, lead author of the research and a research fellow at the National Health and Medical Research Council in Australia, told Healthline.

There is no established, clear definition for IVF add-ons, but generally they are considered procedures, techniques, or medicines that can be used in addition to standard IVF procedures with the goal of improving the likelihood of a successful conception and birth.

IVF add-ons may include acupuncture, pre-implantation genetic testing for aneuploidy, Chinese herbal medicine, endometrial scratching, growth hormones, assisted hatching, aspiring, melatonin, and prednisolone.

Many of these IVF add-ons are commonly used in the United States.

Pre-implantation genetic testing for aneuploidy is increasingly used in the U.S. as is the endometrial receptivity array (ERA), assisted hatching, growth hormone, and time-lapse imaging of embryos, Dr. Molly Quinn, an assistant clinical professor of obstetrics and gynecology in the division of reproductive endocrinology and infertility at the David Geffen School of Medicine at the University of California Los Angeles, told Healthline.

In general the idea behind many of the add-ons is that their use is unlikely to be harmful and may prove to be beneficial. This may be true of acupuncture, for example. However, many of the laboratory techniques described have yet to have high level safety data, she noted.

The researchers found that 72 percent of the women surveyed had incurred additional costs from IVF add-ons, despite a lack of evidence supporting the efficacy of the additional treatments.

IVF add-ons are not considered to be necessary for achieving pregnancy or live birth through IVF. They are optional extras,' Dr. Lensen said. There is some moderate or poor-quality evidence supporting some add-ons. However, most are not supported by even this level of evidence and none are supported by high-quality evidence.

She argues that those undertaking IVF may feel like they have no other option than to try add-on treatments.

Desperation may well play a part. We know that many people having IVF are desperate. They will do almost anything that might help them to conceive, including opting for unproven or experimental treatments, such as IVF add-ons, Lensen said.

Quinn added this is a major concern in the United States where coverage for fertility treatments such as IVF is limited in most states.

Some patients have funds for a single attempt. Patients also have often arrived at years of unsuccessful attempts to conceive naturally or with less aggressive interventions before arriving at IVF. This does create a vulnerable patient population, she explained.

IVF is a significant financial commitment for most, Quinn added. Everyone is trying to maximize their chance for success Patients may come to the clinic and ask providers if there is anything else that may be helpful. I suspect that in some scenarios this is where the conversation shifts to discussion of add-ons.

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Researchers Say IVF Add-On Treatments Are Ineffective - Healthline

Born in the city of Rosario, Lionel Messi's fight began from the very start of his football career. Fighting his way through a growth hormone deficiency from a young age to reaching the pinnacle of football with Barcelona, he is always involved in conversations involving the best player to have ever played the sport.

Looking back at his sparkling career, Messi's trophy cabinet had everything a player could wish for at a club level. However, the lack of a title with the national team at a senior level caused a void too huge for the Argentine to escape despite his consistent excellence on the pitch for Barcelona.

RELATED| Messi's Argentina beats Brazil 1-0 to win Copa America 2021

As Messi lifts the title at the end of Copa America 2021 after beating Brazil at the historic Maracana Stadium in Rio, life comes full circle for the boy from Rosario as he gifts his country its first international title since 1993 at a stadium where he had to undergo the crushing World Cup final defeat against Germany in 2014.

This was his Copa America. He was the driving force behind the stellar campaign of the Albiceleste as he racked up four goals and five assists on his way to the final.

This win, however, came after the heartbreak of losing four finals.

Copa America 2007

The string of disappointments started in 2007 where a young Lionel Messi saw his team lose 3-0 to a strong Brazil side as Julio Baptista, an Roberto Ayala own goal and Dani Alves snatched the title away from Argentina and extended its wait for a national title.

World Cup 2014

This was Argentina's golden period under manager Alejandro Sabella. Spearheaded by Messi, Argentina had the chance to lift the World Cup title on Brazilian soil. But Germany broke Argentine hearts yet again as Mario Gotze's 113th minute goal was enough for Germany to win the World Cup.

Lionel Messi and his teammates react after Germany's 1-0 World Cup victory in extra time at the Maracana Stadium in Rio de Janeiro, Brazil. - AP

Copa America 2015

The next heartbreak came in 2015 as Argentina and Chile played out a 0-0 draw and the match went to penalties. Argentina lost that shootout and what made it even more bitter for Messi was the fact that he could not convert his spot-kick. Gonzalo Higuain and Ever Banega also missed their respective penalties.

Argentina's Lionel Messi reacts after Argentina's Gonzalo Higuain missed his penalty kick against Chile during the Copa America final in 2015 - AP

Copa America 2016

Argentina faced Chile again in 2016 at the Copa America Centenario final staged in the United States of America. The match was tied after extra time once again, which forced a penalty shootout. As fate would have it, Messi would go on to miss his penalty and Chile was crowned champion for the second consecutive year.

Messi announced his international retirement after that defeat, only to reverse the decision some months later.

RELATED| Copa America Final In Pictures: Messi wins first title with Argentina

As Argentina rejoices its first title after 28 years of heartbreak, the country will remember Messi's exploits- a story of numerous up and downs and how the quiet number 10 carved out his moment, overcame multiple setbacks and almost single-handedly led his country to a record-equalling 15th Copa America title.

Amidst all the celebrations, Argentina will also remember another number 10 who overcame all odds to win football's most prestigious title for the country - a certain man named Diego Armando Maradona.

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Messi and his tryst with Argentina: Light at the end of the tunnel after 28 years - Sportstar