Effect of meal composition and alcohol consumption on postprandial glucose concentration in subjects with type 1 diabetes: a randomized crossover…

This article was originally published here

BMJ Open Diabetes Res Care. 2021 Oct;9(1):e002399. doi: 10.1136/bmjdrc-2021-002399.

ABSTRACT

INTRODUCTION: Meal composition is known to affect glycemic variability and glucose control in type 1 diabetes. The objective of this work was to evaluate the effect of high carbohydrate meals of different nutritional composition and alcohol on the postprandial glucose response in patients with type 1 diabetes.

RESEARCH DESIGN AND METHODS: Twelve participants were recruited to this randomized crossover trial. Following a 4-week run-in period, participants received a mixed meal on three occasions with the same carbohydrate content but different macronutrient composition: high protein-high fat with alcohol (0.7g/kg body weight, beer), high protein-high fat without alcohol, and low protein-low fat without alcohol at 2-week intervals. Plasma and interstitial glucose, insulin, glucagon, growth hormone, cortisol, alcohol, free fatty acids, lactate, and pH concentrations were measured during 6 hours. A statistical analysis was then carried out to determine significant differences between studies.

RESULTS: Significantly higher late postprandial glucose was observed in studies with higher content of fats and proteins (p=0.0088). This was associated with lower time in hypoglycemia as compared with the low protein and fat study (p=0.0179), at least partially due to greater glucagon concentration in the same period (p=0.04). Alcohol significantly increased lactate, decreased pH and growth hormone, and maintained free fatty acids suppressed during the late postprandial phase (p<0.001), without significant changes in plasma glucose.

CONCLUSIONS: Our data suggest that the addition of proteins and fats to carbohydrates increases late postprandial blood glucose. Moreover, alcohol consumption together with a mixed meal has relevant metabolic effects without any increase in the risk of hypoglycemia, at least 6 hours postprandially.

TRIAL REGISTRATION NUMBER: NCT03320993.

PMID:34620620 | DOI:10.1136/bmjdrc-2021-002399

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Effect of meal composition and alcohol consumption on postprandial glucose concentration in subjects with type 1 diabetes: a randomized crossover...

Jay Underwood went to the neighborhood store to pick up some groceries and never came home – oregonlive.com

Jay Underwood drove to the nearby WinCo on March 17 to buy some cabbage and other groceries to prepare a late-night St. Patricks Day dinner.

It should have been a quick trip just three blocks away, but he didnt return. His wife kept calling and texting and then grumbling when he didnt respond.

Becky Underwood checked her Life360 family locator app, which placed him at the store off Northeast 122nd Avenue based on his phones GPS location.

She sent her son, Jeffrey Casey, to go find him.

When Casey arrived at WinCo, he found the store cordoned off with yellow police tape and police cars surrounding it.

He saw his mothers white Toyota Avalon parked in the lot. Underwood, his stepfather, had taken the car to the store.

Casey told the first officer he saw, Im looking for my father.

Police had him stay put and a detective eventually questioned him in a mobile command center set up outside the store.

Casey said he wasnt told what had happened.

Becky Underwood, meanwhile, had been watching TV and learned someone had been shot inside the WinCo.

I knew his phone was inside that store, she said. My first thought was he was being held up as a witness.

Hours later, Portland homicide Detective Brad Clifton arrived at their home. He told them Jay Underwood had been shot and killed inside the WinCo.

Court records and interviews by The Oregonian/OregonLive reveal the breadth of the crime and its strikingly public nature -- a fatal shooting in a crowded store followed by an armed carjacking in the parking lot.

Prosecutors, a defense attorney and family members all have indicated they dont know what provoked the shooting.

It could have involved drugs or might have been spurred when the alleged gunmans ex-girlfriend called Underwood moments before he was killed, police and a prosecutor said in court. But they dont know for sure, they said.

Jay Underwood was the 21st person to die in a homicide in Portland in a year on pace to set a record for violent deaths in the city.

FOR MORE ON THE PEOPLE WHO DIED, NEW DETAILS OF CASES, go to Portland Homicides: Under the Gun

I havent accepted it yet, Becky Underwood said in late July, three months after the shooting, as she sat with her son outside their home.

In my mind, hes going to come around the corner from that shed over there and come in, she said. It doesnt seem real. I do know hes gone, but I just expect to see him come home anytime because he was always here.

SHOT IN THE BREAD AISLE

Jay Underwood pulled into the WinCo lot at 9:43 p.m., the stores surveillance video shows.

His friend Blake Daniels had stopped by their home earlier and then rode with him to the store but stayed behind in the car as Underwood entered the store alone.

Less than 10 minutes later, the video shows Daniels emerging from the Toyota and heading into WinCo as well, dressed in a dark coat, rust-colored hat and green shoes with tan soles.

He walked past the shelves of bread holding a gallon jug of water and stopped briefly at a rack by a checkout aisle.

He grabbed a box of Hostess cupcakes and walked back along the bread shelves. He got to the end of the aisle before he turned around, slowly walked back, reached into his right pocket, pulled a gun out and appeared to fire it at close range at a man standing in front of the rows of bread, according to the video.

The man, Underwood, instantly crumbled to the floor.

Daniels didnt break his gait, turned and ran out a checkstand aisle.

He had been in the WinCo for only two minutes, according to the video and Clifton, the homicide detective.

Police found Underwood lying face up on the floor between the bread aisle and a row of cashier lines. A single 40-caliber shell casing lay about 10 feet from his body. He was dead at the scene from a gunshot wound to the chest, Clifton testified in court.

Video surveillance footage from the WinCo on March 17, 2021 shows Jay Underwood's friend, Blake Maurice Daniels, who is accused of shooting Underwood once in the chest inside the store and then walking out, holding a jug of water and cupcakes, before carjacking a vehicle in the parking lot, police say.Surveillance video

Outside the store, Daniels walked up to an occupied Subaru Forester that had just pulled into the parking lot and climbed into the back seat on the drivers side, video shows.

Holding a black handgun, he ordered the motorist to drive, according to the detective. The driver and his wife quickly bailed out of their car and Daniels took off in it.

Investigators who arrived at the scene reviewed the video and interviewed Underwoods stepson, then distributed a flier with Daniels photo and description of the stolen Subaru.

The next morning, police found Daniels and arrested him at the Rodeway Inn near Northeast 97th Avenue and Sandy Boulevard, according to the detective.

The Subaru was discovered on a dead-end street at Northeast 106th Avenue near San Raphael Street, with the keys left inside. A nearby resident reported it to police.

Not far from the abandoned SUV, police found a dark-colored jacket and a discarded rust-colored beanie, Clifton said.

Jay Underwood, left, Becky Underwood and her son, Jeffrey Casey, on vacation in Mexico in 1996. Photo courtesy of Becky Underwood

PHONE CALL PRECEDED SHOOTING

Police patted down Daniels. He had a black case on him containing two bags of methamphetamine and a bag of heroin, they said.

His ex-girlfriend, Heather Marie Casillas, told officers that Daniels began dealing drugs -- methamphetamine, heroin, cocaine and OxyContin -- after he was laid off during the coronavirus pandemic, Clifton testified.

She told police Daniels was dealing drugs with Underwood and by November 2020, the two were together on a regular basis -- almost every day for months, the detective testified.

Daniels also was using human growth hormone and steroids and had become increasingly angry and volatile, she said, according to the court records. They had broken up in recent weeks.

On the evening of March 17, Casillas called Jay Underwood to see if he knew where Daniels was. She planned to retrieve some belongings from an apartment she had shared with Daniels and wanted to make sure he wasnt there when she stopped by.

Underwood didnt answer her first call. But they connected by phone at 9:48 p.m. when Underwood was in the WinCo. He told her he was shopping and that Daniels was with him, waiting out in the car.

He said hed call her back. He never did.

Police investigators and the prosecutor said they dont know exactly what prompted the shooting.

Deputy District Attorney Melissa Marrero said in court that it could have had something to do with a drug deal or the fact that Daniels ex-girlfriend was calling Jay Underwood and he took her call.

There are multiple potential motives here, she said.

William Walsh, Daniels lawyer, argued at a bail hearing that prosecutors failed to prove any animosity between the two men. They both arrived at the store together and there was no evidence of a fight or dispute, he said.

It doesnt seem to be as rational as one would think, Walsh said.

We were a happy couple, Becky Underwood said. "Everyone has their moments. But being together for so long, we finally figured out all that stupid stuff. Photo courtesy of Becky Underwood

HE DID EVERYTHING FOR ME

Jay Underwood had told his wife he didnt want a funeral when he died.

He really enjoyed life. He said, Have a party, Becky Underwood recalled.

She respected his wishes. She planned instead to host a celebration of his life, but hasnt yet.

She said she has no idea what propelled the killing. Both she and her son said they were surprised to learn at a court hearing that Jay Underwood had anything to do with drug dealing.

Becky Underwood said she needs some way to let out her rage and has considered going to the beach to just scream.

Her husband, she said, had been her caretaker for about the past 10 years after working 24 years for ADP, the human resources software provider. He supported her as she battled breast cancer, struggled with a detached retina and most recently suffered hip pain that hampered her ability to walk.

He did everything for me, she said. Despite her efforts to help out, He cooked all the meals. He always said, I just want you to be comfortable.

Jay Underwood was born in Boise, lived in Spokane as a child and later moved to Portland. He would have turned 61 on July 3. He and his wife would have celebrated their 30th wedding anniversary on Aug. 24.

He had many interests. He loved to barbecue and cook -- prime rib and carbonara were among his favorites. He and his wife used to go camping in Newport and enjoyed vacationing in Cabo San Lucas, Mexico.

At one time, he was president of a local Mopar car club and the couple attended car shows across the state. He enjoyed fixing cars and would head out the door at all hours to help neighbors and friends whose cars had broken down or run out of gas, his wife said.

He considered starting his own contracting company because he was very much a fixer or would make something to fix something, Becky Underwood said.

He and Daniels had talked about perhaps starting a carpet-cleaning business in the future, she said.

Police say Blake Maurice Daniels fatally shot Jay Underwood inside a WinCo in Northeast Portland on March 17, 2021, and then carjacked a Subaru that was occupied and in the parking lot as he walked out of the store. The stolen Subaru was found three days later on Northeast 106th Avenue, according to police and prosecutors.Court exhibit

SUSPECT HAD RECENT ARREST

Earlier this summer, Becky Underwood attended Daniels bail hearing at the Multnomah County Courthouse.

She said she was sad and surprised to see Daniels. But I got satisfaction seeing him all chained up, she said.

Before the prosecutor played the WinCo video that captured the shooting, she left the courtroom. She said she couldnt bear to see it.

Less than two weeks before the killing, Daniels had been arrested on allegations that he came after his ex-girlfriend, Casillas, with a rifle when she tried to gather some of her things from the apartment. He was accused of being a felon in possession of a firearm, unlawful use of a weapon and menacing.

Three days later, Daniels was placed on supervised release on the weapons charges pending trial, and prosecutors dropped the menacing charge.

He was ordered not to have a gun and to report to a supervision officer on March 9 , ten days before Underwoods killing. He never reported, according to court records.

Daniels is now being held without bail on an 11-count indictment. Hes pleaded not guilty to second-degree murder with a firearm, two counts of unlawful use of a firearm, one count of first-degree robbery with a gun, two counts of unauthorized use of a vehicle, felon in possession of a firearm, possession of methamphetamine, possession of heroin and delivery of meth and delivery of heroin.

Although the neighborhood WinCo used to be their go-to grocery store, neither Becky Underwood nor her son will step back inside again, they said.

Casey said hes moved back in with his mother and is watching over her now.

Becky Underwood is left with her last memory of her husband, quickly kissing her goodbye before he left for the store. We sort of just brushed lips, she said.

I never thought it would happen to me... always thought it would happen to someone else, she said. You just dont know when someone walks out your door.

-- Maxine Bernstein

Email at mbernstein@oregonian.com; 503-221-8212

Follow on Twitter @maxoregonian

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Jay Underwood went to the neighborhood store to pick up some groceries and never came home - oregonlive.com

Update on the latest sports | National news from the Associated Press | wrex.com – WREX-TV

MLB-NL WILD CARD

Dodgers win on Taylor's blast

LOS ANGELES (AP) Chris Taylor has put the Los Angeles Dodgers into the NL Division Series.

Taylor slammed a two-out, two-run homer off Alex Reyes in the bottom of the ninth to give the Dodgers a 3-1 triumph over the St. Louis Cardinals. Reyes entered the game after Cody Bellinger was issued a two-out walk by losing pitcher T.J. McFarland.

A wild pitch by Max Scherzer scored Tommy Edman and gave the Cardinals the lead in the first inning. It remained 1-0 until Justin Turner unloaded a home run off Adam Wainwright in the bottom of the fourth.

Dodgers manager Dave Roberts put the outcome in the hands of his bullpen after Scherzer was lifted with two on and one out in the fifth.

Wainwright had allowed four hits and two walks with five strikeouts over 5 1/3 innings.

The two clubs were a combined 1-for-15 with runners in scoring position until Taylor's blast.

The Dodgers get to face the 107-win San Francisco Giants, who say Logan Webb will start Game 1 on Friday. Webb won the NL West clincher on Sunday, hitting a two-run homer and working into the eighth inning.

Kevin Gausman gets the starting nod for the Giants in Game 2.

MLB PLAYOFFS

ALDS open Thursday

UNDATED (AP) The two American League Division Series begin on Thursday.

The top teams in the AL East are squaring off in the Division Series. The Red Sox led the division by 4 games on July 7, only to finish eight games behind the Rays. Tampa Bay won the season series, 11-8 despite losing their first four meetings with Boston.

Shane McClanahan starts Game 1 for the Rays on Thursday after going 10-6 during the regular season. Hell be opposed by Eduardo Rodriguez.

Chris Sale could start Game 2 against rookie Shane Baz.

Bosox manager Alex Cora said Wednesday that hes not sure J.D. Martinez will be available due to an ankle injury.

The White Sox and Astros were separated by just two wins as they captured their respective division titles, but Houston took the season series, 5-2. The Astros are making their fifth consecutive postseason appearance. The White Sox are in consecutive playoffs for the first time in franchise history.

A pair of Lances are the Game 1 starters. Lance Lynn pitches for the White Sox after going 11-6 with a 2.69 ERA in the regular season. The Astros counter with Lance McCullers Jr., who was 13-5 with a 3.16 ERA.

The Astros will send Framber Valdes to the mound for Game 2 against Lucas Giolito.

MLB-NEWS

Padres fire Tingler after second-half collapse

SAN DIEGO (AP) The San Diego Padres have fired Jayce Tingler, who presided over the biggest collapse in franchise history just a season after finishing second in voting for NL Manager of the Year.

General manager A.J. Preller announced the move three days after the Padres finished 79-83 and in third place in the NL West, 28 games behind San Francisco.

Tinglers fate was sealed during a brutal freefall that saw the Padres go from a one-game lead for the NLs second wild-card spot on Sept. 9 to being eliminated from playoff contention with seven games left.

NFL-MOVES

Fields now Bears first-string QB

LAKE FOREST, Ill. (AP) After resisting the move, Chicago Bears coach Matt Nagy has made Justin Fields his first-string quarterback going forward, moving veteran Andy Dalton into the backup role.

The former Ohio State quarterback and a first-round draft pick had played against Detroit and Cleveland as the starter but only because of veteran Daltons knee injury.

Dalton is recovered from a bone bruise and has resumed practicing this week.

In other NFL news:

Denver Broncos coach Vic Fangio says quarterback Teddy Bridgewater has a chance to practice Thursday after leaving Sunday's game against Baltimore with a concussion. Fangio says Bridgewater is improving and was cleared to lift weights with the team and attend meetings.

The Panthers have acquired veteran cornerback and 2019 NFL Defensive Player of the Year Stephon Gilmore from the Patriots for a 2023 sixth-round draft pick. The moves comes after Gilmore and the Patriots couldnt come to terms on a new contract.

Carolina running back Christian McCaffrey returned to practice Wednesday on a limited basis after missing Sunday's 36-28 loss to the Cowboys with a hamstring injury.

Browns starting linebacker Anthony Walker Jr. has returned to practice and will likely be activated later this week to play against the Chargers. However, the Browns are without defensive end Jadeveon Clowney as well as cornerbacks Denzel Ward and Greg Newsome II and nickel back Troy Hill.

The Cowboys are moving on from linebacker Jaylon Smith without getting into the specifics of the decision to release their leading returning tackler four games into 2021. One of the factors was a looming $9.2 million guarantee on Smiths 2022 salary if he got injured.

Washington has put tight end Logan Thomas on injured reserve with a hamstring injury. Thomas absence for at least the next three games could open the door for Sammis Reyes to become the first person from Chile to play in an NFL game.

The Lions put standout center Frank Ragnow on injured reserve, another setback for a banged-up winless team. The Lions are expected to give center Evan Brown his first career start Sunday at Minnesota.

Jaguars coach Urban Meyer publicly apologized for the third consecutive day Wednesday and said he never considered resigning after his inexcusable behavior at an Ohio bar was caught on camera and released on social media. Meyer says several members of the teams leadership council have expressed their support. Team owner Shad Khan publicly reprimanded the Meyer for his actions at the bar last weekend.

The NFL Players Association says it has sent a formal request to the league for information about Washingtons practice facility being searched by federal authorities last week. The NFLPA says the situation directly impacts player health and safety and that the collective bargaining agreement obligates teams to adhere to state and federal laws. Head athletic trainer Ryan Vermillion was put on administrative leave for what a Washington spokesman called an ongoing criminal investigation unrelated to the team.

Jets coach Robert Saleh says safety Marcus Maye has the teams support. The star player is dealing with legal issues after being charged in February with drunken driving after a car crash in Florida. Saleh declined to say whether he and the team previously knew about the accident and arrest that was first reported Monday night.

Suspended Dallas offensive lineman Lael Collins has sued the NFL and Commissioner Roger Goodell. Collins is seeking an injunction to stop the remaining two games of a five-game ban over substance-abuse violations. The suit claims the NFL suspended the seventh-year player for missed tests when the labor agreement reached in 2020 no longer allowed for suspensions over missed tests or positive marijuana tests.

NFL RATINGS

NFL ratings up 17%, averaging 17.3 million viewers

UNDATED (AP) NFL games are averaging 17.3 million viewers on television and digital, a whopping 17% increase over last season and 3% compared to two years ago.

Whether or not the league can maintain that level of growth remains to be seen.

Last season was played during the pandemic, mostly in empty stadiums. Also, many peoples viewing habits changed in a presidential election year.

Four of the five league broadcasters have growth above 20%.

NBA-NEWS

No testing for marijuana in NBA this season

NEW YORK (AP) The NBA has agreed to not randomly test players for marijuana this season.

Its a continuation of the policy that was put in place last year for the restart bubble and has remained since. Drug testing will continue for things such as human growth hormone, other performance-enhancers and drugs of abuse such as methamphetamine, cocaine and opiates.

More than half of the states in the U.S. have decriminalized possessing small amounts of marijuana.

NHL-NEWS

AP source: NHL investigates Kane for fake vaccine card

UNDATED (AP) San Jose Sharks forward Evander Kane is being investigated on allegations that he used a fake COVID-19 vaccination card.

A person familiar with the investigation told The Associated Press about the inquiry.

Using a fake vaccination card is illegal in both the United States and Canada, as well as against NHL rules.

This probe is just the latest into Kane, who was cleared last month of allegations made by his estranged wife that he bet on NHL games, some involving his own team.

In other NHL news:

Canadiens coach Dominique Ducharme says he does not expect Carey Price to practice before the start of the regular season, making the goaltender doubtful for the opener at Toronto. Ducharme says Price is recovering from a non-COVID-19 illness and offseason surgery to repair a torn meniscus.

The Coyotes have signed forward Alex Galchenyuk (gal-CHEHN-yuhk) to a one-year deal. The 27-year-old returns to Arizona after scoring five goals with eight assists with Ottawa and Toronto last season.

Quinton Byfield was placed on injured reserve by the Kings, a day after fracturing his left ankle in a preseason game. The second overall pick in the 2020 NHL draft was hurt in the third period of the Kings 4-1 loss to the Coyotes.

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Update on the latest sports | National news from the Associated Press | wrex.com - WREX-TV

Global Human Growth Hormone Market Witness an Outstanding Growth and Strong Revenue and Forecast to 2030 | AnkeBio Co., Ltd, Ascendis Pharma A/S, BTG,…

Latest statistical data titled as Human Growth Hormone has been published by Absolute Markets Insights. The report offers an overview of various features of recent trends such as opportunities, developments which are comprehensively discussed in order to provide an in-depth analysis of the progress of the industries. Effective exploratory techniques such as qualitative and quantitative analysis are also used in order to explore accurate data.

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In terms of revenue, global human growth hormone market was valued at US$ 4109.23 million and is expected to reach US$ 5819.32 million, growing at an estimated growth rate of 8.9% over the forecast period. The study analyses the market in terms of revenue across all the major regions, which have been bifurcated into countries.

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Global Human Growth Hormone Market Witness an Outstanding Growth and Strong Revenue and Forecast to 2030 | AnkeBio Co., Ltd, Ascendis Pharma A/S, BTG,...

Blessing Okagbare charged with use of two banned substances – AW – Athletics Weekly

Nigerian sprinter charged with use of Human Growth Hormone, EPO and refusal to co-operate with investigation

Blessing Okagbare, who competed at the Tokyo Olympics in the womens 100m heats before being provisionally suspended, is facing fresh charges from the Athletics Integrity Unit.

The AIU have charged the 32-year-old Nigerian an Olympic and world silver medallist and two-time Commonwealth champion with use of the banned substances Human Growth Hormone (HGH) and EPO, while also allegedly failing to co-operate with the investigation.

The use of HGH was found in an out-of-competition sample collected on July 19 before it was reported to the AIU on July 30, the day upon which Okagbare won her 100m heat at the Olympics. She was then provisionally suspended one day after that race and forced to fly home from Tokyo.

In addition, EPO also known as Erythropoietin was found in another of the Nigerians out-of-competition samples, on June 20. Two days earlier, Okagbare had run a wind-assisted 10.63 for 100m in Lagos.

The AIU also state that Okagbare failed to comply with a formal requirement to produce relevant documents, records and electronic storage requirements by September 15.

She denies all charges and the case will now likely be heard by an independent Disciplinary Tribunal.

Okagbare is coached by Rana Reider, who has trained Christian Taylor andDafne Schippers while Brits Daryll Neita and Adam Gemili are currently part of his coaching group in Florida.

While there is no suggestion of wrongdoing on their part, UK Athletics spoke to their standards, ethics and rules committee regarding procedural advice when news of Okagbares HGH positive test broke on July 31.

The Nigerian broke on to the scene at Beijing 2008 when she won silver in the long jump before making an impact in the sprints, winning a bronze medal in the 200m at Moscow 2013.

Her personal bests are 10.79 in the 100m, 22.04 in the 200m and 7.00m in the long jump.

For the latest athletics news, events coverage and updates, check out the AW homepageand our social media channels onTwitter,FacebookandInstagram

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Blessing Okagbare charged with use of two banned substances - AW - Athletics Weekly

Is SHIB Going to be the New DOGE? Could This Meme Coin be the Next Millionaire Maker? – Tech Times

Urian B., Tech Times 08 October 2021, 11:10 pm

(Photo : Image from Unsplash Website) Is SHIB Going to be the New DOGE? Could This Meme Coin be the Next Millionaire Maker?

Shiba Inu SHB has just emerged as one of the best unexpected investments that is heading into Q4 of 2021. This is with its price rising massively by over 390% during the first week of October 2021.

The spin-off meme crypto, however, is risking wiping most of those gains in the sessions to come. Yuriy Bishko, a certain Ukraine-based market analyst, just recently discussed the potential bearish scenario that based SHIB prices on trends, as seen on TradingView.

The price trend actually seems to look very similar to DOGE's market spike earlier this 2021. As an example, SHIB October 2021 prices rallied following five whole months of consolidation in the $0.00000398-wide price range. Quite similarly, DOGE faced a sideways trend in February to April 2021.

This is where the bids bounced all the way between $0.0471 and $0.0630, which served as a basis for the new 500%-plus price rally that happened in late April 2021. Bishko noted that traders that bought Shiba Inu tokens during the whole sideways consolidation phase should be able to sell at least 20-30% of their own positions should they still hold after the rally.

SHIB's net breakout stretch then exceeded 500%. It was noted that traders should dump yet another 70-80% of their own net holdings. This is mainly due to Dogecoin's price rally that happened in April 2021, which saw a 60% correction. Once again, the triple in value of SHIB also coincided with a recent tweet by Elon Musk regarding the Shiba Inu crypto.

The whole profit-taking strategy actually appeared as SHIB resumed its own uptrend after falling a massive 41% in price correction during the previous session. SHIB had rallied to almost 27.5% in order to hit an intraday high of a whopping $0.00002919 which was much in line along with similar upside moves that were made across all of the top crypto assets, which include BTC and ETH.

According to the story by CoinTelegraph, small-cap tokens actually typically tail trends in the noted top-cap markets. An example of this is SHIB's 390% quarter to date or QTD price rally, which also coincided with the massive 30% bump of Bitcoin during the same period.

Read Also:Cardano Price Prediction | What are the Top 10 Upcoming Blockchain and DAPP Projects on This Cryptocurrency?

During the exact same time, SHIB's daily relative strength index or RSI identified the crypto's current price valuation as officially overbought. Analysts also consider an RSI reading above 70 as excessively valued when it comes to the asset. For those looking into potential big cryptocurrencies, check out the best cryptocurrencies of September 2021.

This typically results in a follow-up with either a price correction or a new sideways consolidation. A Twitter-based independent market analyst, Bleeding Crypto, anticipates that SHIB could retest its own sessional hgh of a whopping $0.00003528. Before investing in any cryptocurrency, it is important to DYOR.

Related Article:AMC Recognizes Dogecoin as Cryptocurrency to Buy Digital Gift Cards

This article is owned by Tech Times

Written by Urian B.

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Is SHIB Going to be the New DOGE? Could This Meme Coin be the Next Millionaire Maker? - Tech Times

Horizon Theatre Announces Return to Live and In-Person Theatre with SOUTHBOUND HALLOWEEN – Broadway World

Celebrate the Halloween season with the grand reopening of the Horizon Theatre Company with Southbound Halloween: The Spooky, The Sexy, The Scandalous - a night of hilarious, spine-tingling, and suspenseful real-life stories told live onstage in Little Five Points.

The evening will also feature musical guest, The Tomb Tones playing ghoulishly good tunes. The interactive special Halloween show and event are free to the public for one night only on Monday, October 18, at 8:00 pm. This one-of-a-kind and very Little Five Points Halloween event represents a shift of Horizon's hugely successful Southbound digital platform to live, in-person performances on the Horizon stage along with livestream through Zoom.

Hgh energy hosts for Southbound Halloween: The Spooky, The Sexy, The Scandalous are Megan Hayes (Horizon's Sex with Strangers and Waffle Palace Christmas) and Brittani Minnieweather (Sweet Water Taste and The Ghosts of Little Five Points). Featured guests and stories will include: Horizon favorite Gina Rickicki (The Ghosts of Little Five Points) - "Don't let a crappy engagement ruin your favorite holiday.

Matter of fact, don't let Anyone ruin things you love"; Jennifer Alice Acker (Freaky Friday) - "Every lesson I ever needed to learn, I learned on Halloween.", Spencer Stephens (Atlanta-area actor/singer/puppeteer and educator); Laura Morales (Atlanta actor and story teller) - "Bride La Loca Lopez Perez "Smith" desperately looking for her husband, "Capitan Smith"'; and musical guest, The Tomb Tones - "50s rock'n'roll collides with punk rock mania in The Tomb Tones' spook show bizarro! Dance the night away to hilarious hair-raising tunes about undead romance, scatter-brained spectres, and monster movies gone wrong!" Bios of all artists are listed below. As in all Southbound episodes, audiences will have the chance to participate in the fun by responding to prompts and questions from hosts.

This special Southbound is Episode 6 of the Southbound: True Life Tales from the ATL and Beyond original programming. This monthly series features real-life stories and music from Atlanta writers, musicians, actors, journalists, leaders, celebrities - and just plain folks with great ATL stories to tell. Learn more about and watch previous episodes of Southbound here: https://www.horizontheatre.com/southbound-true-life-tales-from-the-atl-and-beyond/

For this exciting return to live and in-person performances, Horizon is committed to being COVID safe. The theatre will follow its new COVID policy and procedures, including proof of vaccines for all audience members, artists, and staff; masks required for all patrons and staff; enhanced cleaning and sanitation; and HVAC system enhancements to deliver fresh air MERV-13 filtration. Horizon's full COVID policy and procedures can be found: https://www.horizontheatre.com/covid-19-policies-procedures/

"We're thrilled to re-open in theatre with this fun, one-night-only event." says Co-Artistic Director Lisa Adler. We always envisioned Southbound as a live show, and now it will be - and we'll be back for Thanksgiving and Winter Holiday episodes as well. Come kick-off the Halloween season with us!"

Patrons who wish to watch Southbound Halloween: The Spooky, The Sexy, The Scandalous from home can still be part of the fun as Horizon will live stream on Zoom at the same time.

This special Southbound event will begin at 8:00 pm, both live and online. Horizon Theatre is located at 1083 Austin Avenue NE 30307 at the corner of Euclid and Austin Avenues. Tickets for the show are free so bring your friends. Horizon is excited to share reopening with everyone! For tickets available at https://tickets.horizontheatre.com/southbound or call (404) 584-7450. Come in full costume, a festive hat, or mask or keep it simple and come as you are. Best costumes will be highlighted!

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Horizon Theatre Announces Return to Live and In-Person Theatre with SOUTHBOUND HALLOWEEN - Broadway World

Heartland Group Holdings’ (NZSE:HGH) one-year earnings growth trails the respectable shareholder returns – Simply Wall St

Passive investing in index funds can generate returns that roughly match the overall market. But you can significantly boost your returns by picking above-average stocks. For example, the Heartland Group Holdings Limited (NZSE:HGH) share price is up 84% in the last 1 year, clearly besting the market return of around 8.4% (not including dividends). If it can keep that out-performance up over the long term, investors will do very well! The longer term returns have not been as good, with the stock price only 30% higher than it was three years ago.

The past week has proven to be lucrative for Heartland Group Holdings investors, so let's see if fundamentals drove the company's one-year performance.

View our latest analysis for Heartland Group Holdings

While markets are a powerful pricing mechanism, share prices reflect investor sentiment, not just underlying business performance. One imperfect but simple way to consider how the market perception of a company has shifted is to compare the change in the earnings per share (EPS) with the share price movement.

During the last year Heartland Group Holdings grew its earnings per share (EPS) by 20%. The share price gain of 84% certainly outpaced the EPS growth. So it's fair to assume the market has a higher opinion of the business than it a year ago.

The graphic below depicts how EPS has changed over time (unveil the exact values by clicking on the image).

We know that Heartland Group Holdings has improved its bottom line lately, but is it going to grow revenue? Check if analysts think Heartland Group Holdings will grow revenue in the future.

As well as measuring the share price return, investors should also consider the total shareholder return (TSR). The TSR incorporates the value of any spin-offs or discounted capital raisings, along with any dividends, based on the assumption that the dividends are reinvested. Arguably, the TSR gives a more comprehensive picture of the return generated by a stock. In the case of Heartland Group Holdings, it has a TSR of 93% for the last 1 year. That exceeds its share price return that we previously mentioned. The dividends paid by the company have thusly boosted the total shareholder return.

It's nice to see that Heartland Group Holdings shareholders have received a total shareholder return of 93% over the last year. That's including the dividend. That gain is better than the annual TSR over five years, which is 15%. Therefore it seems like sentiment around the company has been positive lately. Someone with an optimistic perspective could view the recent improvement in TSR as indicating that the business itself is getting better with time. I find it very interesting to look at share price over the long term as a proxy for business performance. But to truly gain insight, we need to consider other information, too. To that end, you should learn about the 3 warning signs we've spotted with Heartland Group Holdings (including 1 which is concerning) .

We will like Heartland Group Holdings better if we see some big insider buys. While we wait, check out this free list of growing companies with considerable, recent, insider buying.

Please note, the market returns quoted in this article reflect the market weighted average returns of stocks that currently trade on NZ exchanges.

When trading stocks or any other investment, use the platform considered by many to be the Professional's Gateway to the Worlds Market, Interactive Brokers. You get the lowest-cost* trading on stocks, options, futures, forex, bonds and funds worldwide from a single integrated account. Promoted

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned. *Interactive Brokers Rated Lowest Cost Broker by StockBrokers.com Annual Online Review 2020

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team (at) simplywallst.com.

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Heartland Group Holdings' (NZSE:HGH) one-year earnings growth trails the respectable shareholder returns - Simply Wall St

Growth Hormone Therapy | risks, cost, side effects

A Growth Hormone Therapy is one of the most common forms of treatment for children and adults who face a deficiency in the growth hormone produced in the body. This is given via injections to the body.

Growth hormone is also known as Somatotropin. It can be injected by the patient themselves or by a family member. Normally produced in the pituitary gland, sometimes this hormone is not sufficient for the body. When administered via injections, this hormone stimulates the cell reproduction and growth in the body.

It has to be taken daily or sometimes more than once in a day. Your doctor will monitor your blood cholesterol levels, sugar levels and certain other levels in order to make sure that they are at a healthy level. He has to make sure before starting with growth hormone as these have an impact on how the patients body responds to insulin.

Although the injections of growth hormone are considered safe, some people do face some side effects. The risks or side effects of growth hormone are:

Most of these symptoms are temporary and resolve on their own. Growth hormone should not be taken by those people who have cancer or tumor. Those who have multiple injuries from trauma should also refrain from using growth hormones. People suffering from severe breathing problems should also avoid using growth hormones.

But if left untreated, a deficiency of growth hormone could lead to increase in risk of heart disease, increase in diabetes, osteoporosis, strokes and high blood pressure.

These injections might lead to cancer and hence research is still on whether they are safe or not. Athletes use them a lot because it enhances their performance and cannot be detected in urine tests.

It causes serious side-effects in some people such as water retention, liver damage, painful joints, etc. another major problem of using this injection is that the bodys pituitary gland stops producing their own hormones and then one has to take these injections lifelong.

Before a few years, the cost of growth hormone therapy was too much at about $1000 per month. This price has now come down to $500 per month and that too depending upon the dosage. This hormone is required in fewer doses in men than in women. Many insurance schemes cover the cost of growth hormone completely.

Growth hormone is a hormone that is naturally produced by the pituitary gland in the body. This gland is located in the brain. Pituitary gland is the master gland in the body and it also manages the production of all the hormones in the body.

This hormone is called growth hormone because it is responsible for the overall growth of a person from a child to an adult. It is also approved by the FDA for use in adults and children.

Growth hormone continues to be produced in the body throughout ones adult life. It is in abundant quantity and plays a vital role in optimizing the overall health and growth of an individual. Adults who face a growth hormone deficiency benefit a lot with growth hormone replacement.

Whenever, there is a permanent damage to the pituitary gland or a tumor in the gland, an external source of growth hormone is quite beneficial. Radiotherapy or surgery may also lead to permanent damage in the pituitary gland. Some people are born with their glands producing insufficient amounts of growth hormone and hence are always deficient of growth hormone.

A variety of tests are done to diagnose the deficiency of growth hormone in adults. One such test is the Insulin Tolerance Test. In this test, insulin is used to lower the blood sugar level which then stimulates the gland to release growth hormone. Blood samples are then taken to capture the response of the growth hormone. If the levels do not rise, it is diagnosed as deficiency.

Such adults have altered body composition and lack in physical performance. They have increased abdominal fat levels, decrease in muscle mass and reduced exercise capacity. Their general wellbeing is often affected leading to less energy and vitality. They are also known to have depressed moods and increased levels of anxiety.

A growth hormone replacement therapy reduced their body fat and increases muscle mass thereby increasing strength and tolerance. Their physical fitness increases and a profound improvement in their cardiac function is observed.

When a child is treated with growth hormone, a deficient child starts growing faster within a couple of months. One also gets to notice other benefits such as increased strength, reduction in body fat and progress in motor development.

Hardly any side effects are seen in children with growth hormone therapy. But cost of life is hampered as the child is required to take injections daily and sometimes as long as he is growing. Some severely deficient kids may need to take the injections throughout their lives.

The treatments could be very costly for the family and the child will have to be closely monitored by the physician every month to see this improvement and rule out side effects of growth hormone therapy.

Parents sometimes worry about the height of their boys. If the doctor assures them that all is well, then such parents should leave it on time. The doctors will prescribe a growth hormone therapy only if there are potential medical causes such as growth hormone deficiency, underactive thyroid gland or genetic disorders. If the boy is short but healthy, then the doctor will not prescribe a growth hormone. In the US, it is approved to treat idiopathic short stature which has no medical cause.A growth hormone might be able to deliver an extra 1 to 3 inches of height but if both the parents are short, it cannot modify the genetic potential. Till now it has not been found out whether treating young boys with growth hormone therapy might have some serious risks later in life. It might increase their risks with diabetes or cancers later in life. Growth hormone is not the only therapy that can be given to kid boys for their idiopathic short stature. Lower doses of androgens might help at times.

The size of the genitals often concerns men. A desire for a longer penis size is common amongst males. Penis size cannot grow after puberty. It starts to grow at the age of 9 and the growth completes till 22 years. Sometimes, it does not grow completely and some residual growth is left. Due to testosterone deficiency, sometimes there is a micropenis which is quite short.

Growth hormone is necessary for penis growth. The penis is constantly under stress and forced to regenerate new tissue and this process occurs smoothly when the body produces ample growth hormone. Taking supplements does lead to accelerated growth in the tissues helping the penile growth.

The body experiences a natural decline in the growth hormone as one ages and one may not need growth hormone at that time. Loss of muscle mass can be directly related to decreased physical activity and health in elder people. Growth hormone directly targets muscle mass and hence it is considered a boon for ageing. If older people are into routine and vigorous physical exercises, then they too can manage to slow down the process of ageing.

It has also become the latest fad for anti-ageing to enable one to look young. After taking growth hormone injections, skin feels tighter and sex drive increases. It is said to reverse the process of ageing or slow it down effectively. It increases the thickness of the skin. It is also said to reduce the appearance of wrinkles and reduces sagging of facial muscles. An external source of growth hormone make sure that all the endocrine hormones are in perfect balance in the body.

A person can become devoid of growth hormone at any age. Some are born with its deficiency. It is better to treat the deficiency else dire circumstances crop up.

Any three of the below mentioned problems in the body are a reason for possible deficiency of growth hormone and one should get it checked by a good doctor:

One should be aware that the deficiency of growth hormone is a medical problem and not a cosmetic issue. Just for aesthetic beauty of your body, one cannot take growth hormone injections without properly consulting the doctor. It could be due to a tumor in the gland which needs to be treated.

Since 1959, GH has been used to increase the growth in children who are naturally deficient or have some condition that impairs their growth. The availability of this hormone increased by manifolds by 1985 when it was created synthetically. It was marketed to be used for children with short stature or stunted growth. The FDA also approved the use of this hormone for children who have a shorter height. Children who had a height below 5.3 inches for boys were supposed to be given this injection.

These children are given continuous injections everyday till their adult height is reached. It is a very costly therapy and a child is said to gain around 2 inches with this therapy. There are some side effects of this therapy like extra leanness, joint pains and increased blood sugar levels.

This hormone increases the concentration of some insulin-like growth factor in the blood which encourages multiplication of cells in the body leading to cancer of prostate or breast in later stages.

It was proved in some studies that patients treated with growth hormones had greater risks of cancer. Individuals who have acromegaly have a higher risk of cancer than others. They have increased joint pains and carpel tunnel syndrome. These effects of acromegaly are enough to prove the dangerous side effects of growth hormone therapy.

But since the hormone is given in very low doses and frequent doses, it does not cause much harm. Those children who have less growth hormone have low risk of cancer. Short men have less risk of prostate cancer and longer longevity than men who are taller.

Men who are healthy but short are in actually no medical problem. This treatment may or may not help them grow their height.

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Growth Hormone Therapy | risks, cost, side effects

10 Benefits of Human Growth Hormone (HGH) and the Surprising …

Blog Hormones 10 Benefits of Human Growth Hormone (HGH) and the Surprising Side Effects

January 28, 2021

Human growth hormone (HGH) or somatotropin is hugely popular in the bodybuilding and athletic world because of its anabolic effects. So whats the deal with this hormone? Can it really improve your performance and build muscle? And if so, at what cost? Check out everything you need to know about human growth hormone below.

HGH, as its name suggests, stimulates cellular growth, reproduction and repair. So by its very nature, HGH is anabolic.

HGH is produced naturally in the pituitary gland a pea-sized organ at the base of your brain. Its released in high amounts as you enter puberty, which is crucial to your growth into an adult. Following puberty it is produced in smaller amounts, and its main role then is to maintain your muscle mass, brain function and sex drive.

HGH production declines as you age (beginning from your late 20s and early 30s), which is why synthetic human growth hormone is also popular as an anti-aging agent.

Synthetic HGH injections are converted by the liver into Insulin Growth Factor 1 (IGF-1). This chemical triggers those cellular growth process we just spoke about. Thats good news for bodybuilders, because it means IGF-1 stimulates muscle protein synthesis. The result? Muscle growth.

Lets dig a little deeper into the benefits of HGH

Higher human growth hormone levels give you more energy, which means youll burn more calories during your workouts and while doing daily activities. And that means youll burn fat and lose weight faster.

Human growth hormone cuts down the time it takes you to recover between both exercises and workouts. If youre doing a circuit-type workout, for example, youll be able to recover faster between exercises when your HGH levels are elevated.

The amount of strength you produce is highly dependant on the amount of HGH you have flowing through your body. Its true that bigger muscles can move bigger weights, but having the strength to move the weights in the first place is paramount.

The increased energy HGH gives you also helps you build more muscle. It takes energy to push heavy weights around. Plus, the previous strength gains benefit goes hand in hand with this one. Extra strength will lead to more muscle and vice versa.

Read more here:Human Growth Hormone for Bodybuilding>>

Higher human growth hormone levels result in better physical characteristics in the body such as healthier hair and faster hair growth.

HGH contributes to the brain as much as the body. When your human growth hormone levels are high, so is your ability to think and focus.

Your sexual function is directly related to your testosterone and human growth hormone output. When they are on an even keel, so is your sexual appetite. HGH can even help you achieve better erections.

You cant always be in a good mood. But if your HGH levels are lower than normal, youll have an even tougher time being happy. However, when your levels are on par, the game changes. Your mood will stay elevated and youre less likely to be anxious.

Its during sleep that your body goes into recovery mode both physically and mentally. If you deprive yourself of sleep, this will have an adverse effect on your wellbeing, and your human growth hormone release.On the flipside, if your HGH levels are normal or high, youll have no trouble falling asleep or staying asleep, which means youll feel more refreshed the next day.

You need strong bones to support your body when youre doing anything physical. Elevated HGH levels keep your bones stronger and more resistant to breaks especially important as you begin to age.

Now for the bad news. Despite all the benefits, theres some surprising and downright dangerous side effects that HGH can give you that might cause you to think twice before getting injected.

HGH overload can cause a condition called acromegaly. This causes certain parts of your body to grow bigger and trust me, not the parts youd like.

HGH makes your bones grow when youre young. But when youre a fully grown adult, you cant grow bigger or taller no matter how much HGH you have. What happens instead is HGH makes your bones thicker instead of longer especially the ones in your hands, feet and face. Not a good look. And the growing pains youll experience are no fun either.

Acromegaly caused by too much HGH can also affect the heart. This is called cardiomegaly, and an enlarged heart means youre more susceptible to heart attacks.

HGH can cause hypoglycemia (low blood sugar). Symptoms of hypoglycemia include lightheadedness, shakiness and fatigue. Hypoglycemia can also increase your risk of getting diabetes.

Youll also know these as moobs, or by their clinical name, gynecomastia. Any way you slice it, as a man, this is not a physical feature you want to be sporting around the beach come summertime.

Caused when your balance of estrogen, testosterone and HGH fall out of whack, gynecomastia can definitely put a damper on your self-confidence levels.

Excess HGH levels put your nervous system under excess strain. The end result can be tingling sensations in your extremities particularly your hands. In some cases, you can also develop carpal tunnel syndrome, which can make even the most routine of daily activities hard to do.

It depends.

Many lifestyle factors can influence the effects of HGH, including nutrition, sleep, stress and the amount of physical activity you perform.

And depending on who you speak to youll more than likely get contrasting opinions on the benefits of HGH on the gym floor. Some users have described the changes brought about by HGH as quite aggressive, and many have commented that the fat burning effect at first is greater than the addition of new muscle mass.

The bottom line is results will always vary between individuals and the dosage theyre using.

One thing that does need to be said is that HGH is not a quick option. You can expect to be taking HGH for months as opposed to weeks.

And considering that HGH is illegal as well as probably the most expensive anabolic available, its both a risky and pricey route to take.

If youve read this far, it should be pretty obvious by now that injecting yourself with human growth hormone is dangerous.

Human growth hormone injections are synthetic and formulated in a lab. They are often used without knowing the exact dose, which can still give you a great return on your investment, but also raises your risk for other issues to crop up down the road.

As well as all the side effects (and dont think youll be so lucky as to get away without experiencing at least one of those), when you inject yourself with HGH youre also putting yourself at risk from infection if the needle you use isnt properly sterilised. Youre also likely to experience inflammation or damage around the injection site.

None of this sounds remotely close to inviting.

The safe way to increase your human growth hormone levels is to use a natural HGH booster.

Rather than filling your body with dangerous, synthetic HGH produced in a lab, good quality human growth hormone supplements, such as HGH-X2, are made from natural ingredients like maca, hawthorn berry and mucuna pruriens, which can help your body produce more of its own HGH.

Growth hormone supplements like these work with your body, rather than against it to naturally boost your HGH levels. Theyre also 100% legal, and nowhere near as pricey as lab-produced HGH.

The CrazyBulk Growth Hormone Stack: How It Works>>

When you increase your HGH levels with a natural HGH supplement, youll get all the benefits of HGH, without the dangerous side effects.

I think its pretty clear which one wins in the HGH injections Vs supplements debate.

Dont be fooled by HGH. Just because its produced naturally by your body, the synthetic form is pretty nasty. And although it can give you some impressive results (when coupled with hard work nothing comes for free) its side effects and the serious damage it can do to your health really arent worth it

As I said above, what you want is a product that mimics HGH but doesnt break your heart (literally) or your wallet.

HGH-X2 is formulated to trigger your bodys pituitary gland into releasing more HGH. Its made from powerful but natural ingredients, and is 100% legal with no side effects.

Click here to find out more about HGH-X2 HGH natural alternative

As long as you play it safe and stick with natural supplements like HGH-X2, theres nothing wrong with giving your HGH levels a boost to help you achieve your bodybuilding and fitness goals.

Increase your strength and get ready to grow some serious muscle mass with CrazyBulks 100% legal steroid alternatives. Rebuild your body and transform that physique with our special bulking range, formulated to help youbulk up FAST!

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10 Benefits of Human Growth Hormone (HGH) and the Surprising ...