Overview | Human growth hormone (somatropin) for the …

Evidence-based recommendations on human growth hormone (somatropin; Genotropin, Humatrope, Norditropin, NutropinAq, Omnitrope, Saizen, Zomacton) for treating growth failure in children.

The recommendations also apply to somatropin biosimilar products that have a marketing authorisation allowing the use of the biosimilar for the same indication.

A minor correction was made to section 6.1 of the guidance in July 2010. This does not affect the funding direction, which applies from the original date of publication in May 2010.

Next review: This guidance will be reviewed if there is new evidence.

How we develop NICE technology appraisal guidance

This guidance replaces NICE technology appraisal guidance on human growth hormone for the treatment of growth failure in children (TA42).

The recommendations in this guidance represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, health professionals are expected to take this guidance fully into account, alongside the individual needs, preferences and values of their patients. The application of the recommendations in this guidance is at the discretion of health professionals and their individual patients and do not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.

All problems (adverse events) related to a medicine or medical device used for treatment or in a procedure should be reported to the Medicines and Healthcare products Regulatory Agency using the Yellow Card Scheme.

Commissioners and/or providers have a responsibility to provide the funding required to enable the guidance to be applied when individual health professionals and their patients wish to use it, in accordance with the NHS Constitution. They should do so in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities.

Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.

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Overview | Human growth hormone (somatropin) for the ...

Dana White: Tony Ferguson not eager to fight right now, but still one of the most talented guys out there – MMA Junkie

UFC president Dana White isnt expecting Tony Ferguson back anytime soon.

According to Islam Makhachev, Ferguson turned down a short-notice opportunity to fight him in Saturdays UFC 267 main card and White says Ferguson hasnt given him any indication that hes ready to compete again.

I dont think so, I dont think hes eager to fight right now, White told UFC Arabia. I think hes taking some time off.

But that doesnt mean White thinks Ferguson is done. Although the former interim lightweight champion who was once on a 12-fight winning streak has dropped three straight to Justin Gaethje, current UFC lightweight champ Charles Oliveira and Beneil Dariush, White still thinks Ferguson has some fight left in him.

Hes still one of the most talented guys out there, White said. When hes ready to come back, well match him up and well see how does.

Ferguson recently went after Conor McGregor, accusing the former UFC dual-champ of using human growth hormone (HGH). McGregor fired back, claiming the pair will fight each other someday.

Ferguson and McGregor have been jawing back and forth for a while now. Both men were previously under the same management at Paradigm, which McGregor co-owns, causing tensions to flare when Ferguson thought he wasnt being properly and fairly represented. As a result, he parted ways with his management group and Ferguson has wanted a piece of McGregor ever since.

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Dana White: Tony Ferguson not eager to fight right now, but still one of the most talented guys out there - MMA Junkie

Growth Hormone – Lab Tests Online

Sources Used in Current Review

Growth Hormone (Blood). University of Rochester Medical Center. Available online at https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=growth_hormone_blood. Accessed October 2019.

Growth Hormone Stimulation Test (Outpatient). Nationwide Childrens Hospital. Available online at https://www.nationwidechildrens.org/family-resources-education/health-wellness-and-safety-resources/helping-hands/growth-hormone-stimulation-test-outpatient.Accessed October 2019.

Growth Hormone Suppression Test. MedlinePlus. Available online at https://medlineplus.gov/ency/article/003376.htm. Accessed October 2019.

Insulin-Like Growth Factor. University of Rochester Medical Center. Available online at https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=167&contentid=insulin_like_growth_factor. Accessed October 2019.

Thyroid Function Tests. American Thyroid Association. Available online at https://www.thyroid.org/thyroid-function-tests/. Accessed October 2019.

Tests for Pituitary Tumors. American Cancer Society. Available online at https://www.cancer.org/cancer/pituitary-tumors/detection-diagnosis-staging/how-diagnosed.html. Accessed October 2019.

Growth Hormone Deficiency. National Organization for Rare Disorders. Available online at https://rarediseases.org/rare-diseases/growth-hormone-deficiency/. Accessed October 2019.

Acromegaly. National Institute of Diabetes and Digestive Diseases. Available online at https://www.niddk.nih.gov/health-information/endocrine-diseases/acromegaly. Accessed October 2019.

(June 7, 2013) Growth Hormone. Medscape. Available online at https://emedicine.medscape.com/article/2089136-overview#a2. Accessed October 2019.

Collett-Solber PF, et al.Diagnosis, Genetics, and Therapy of Short Stature in Children: A Growth Hormone Research Society International Perspective.Horm Res Paediatr. 2019 Sep 12:1-14. doi: 10.1159/000502231. [Epub ahead of print]

Melmed S.Pathogenesis and Diagnosis of Growth Hormone Deficiency in Adults.N Engl J Med. 2019 Jun 27;380(26):2551-2562. doi: 10.1056/NEJMra1817346.

Molitch ME, et al., Evaluation and treatment of adult growth hormone deficiency: an Endocrine Society clinical practice guideline.J Clin Endocrinol Metab. 2011 Jun;96(6):1587-609. doi: 10.1210/jc.2011-0179.

Sources Used in Previous Reviews

Thomas, Clayton L., Editor (1997). Tabers Cyclopedic Medical Dictionary. F.A. Davis Company, Philadelphia, PA [18th Edition].

Pagana, Kathleen D. & Pagana, Timothy J. (2001). Mosbys Diagnostic and Laboratory Test Reference 5th Edition: Mosby, Inc., Saint Louis, MO.

Sadovsky, R. (2002 August 6). Are We Ready for Growth Hormone Therapy in Adults? American Family Physician, Tips form other journals [On-line journal]. Available online athttp://www.aafp.org/afp/20021115/tips/10.html.

Growth Hormone (Human Growth Hormone, HGH, Somatotropin). ARUPs Guide to Clinical Laboratory Testing (CLT) [On-line test information]. Available online athttp://www.aruplab.com/guides/clt/tests/clt_a244.htm.

Growth Hormone Information. The Hormone Foundation [On-line information]. Available online athttp://www.hormone.org/learn/growth.html.

(2002 November 12, Updated). Growth hormone no fountain of youth, study suggests. LaurusHealth.com, Todays Headlines [Online information from Reuters Health]. Available online at http://www.laurushealth.com/healthnews/reuters//NewsStory111220023.htm.

Growth hormone tests. Hendrick Health System, AccessMed [On-line information]. Available online at http://www.hendrickhealth.org/healthy/00049860.html.

Ruppe, M., Reviewed (2002 February 23, Reviewed). Growth hormone. Pennhealth.com Health Illustrated Encyclopedia [On-line information]. Available online at http://www.pennhealth.com/ency/article/003706.htm.

Spengler, R. (2001 April 9, Updated). Growth Hormone. LaurusHealth.com, Medical Tests [On-line information]. Available online through http://www.laurushealth.com.

AACE Clinical Practice Guidelines for Growth Hormone Use in Adults and Children. Available for download at http://www.aace.com/clin/guidelines/hgh.pdf.

Bernal-Mizrachi, C., Updated (2001 June 2, Updated). Growth hormone stimulation test. MedlinePlus Health Information [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003377.htm.

Bernal-Mizrachi, C., Updated (2001 June 1, Updated). Growth hormone suppression test. MedlinePlus [On-line information]. Available online athttp://www.nlm.nih.gov/medlineplus/ency/article/003376.htm.

Ruppe, M. (2002 February 23, Updated). Growth hormone. MedlinePlus [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003706.htm.

Health Resources: Neurosurgery://On-call (2000 February). Understanding Pituitary Tumors. Patient Resources, Disorder of the Month, Pituitary Tumors Feature Article [On-line information]. Available online at http://www.neurosurgery.org/health/patient/detail.asp?DisorderID=19.

Pituitary Overview and Acromegaly. The Hormone Foundation [On-line information]. Available online at http://www.hormone.org/learn/pituitary_1.html.

Anterior Pituitary Function. The Merck Manual of Diagnosis and Therapy [On-line information]. Available online athttp://www.merck.com/pubs/mmanual/section2/chapter6/6c.htm.

Bisp, K. (2001 September 13). Testing the integrity of the system Growth potential and excess. Society for Endocrinology, Endocrine Nurses Training Course [On-line information]. Available online at http://www.endocrinology.org/sfe/training/ent01/ent01_bis.htm.

Pagana, Kathleen D. & Pagana, Timothy J. ( 2007). Mosbys Diagnostic and Laboratory Test Reference, 8th Edition. Mosby, Inc., Saint Louis, MO. Pp. 506 510.

Clarke, W. and Dufour, D. R., Editors (2006). Contemporary Practice in Clinical Chemistry. AACC Press, Washington, DC. Grenache, D. and Willis, M., Chapter 31 Hypothalamic, Pituitary, and Gonadal Disorders. Pp. 351 363.

Wu, A. (2006). Tietz Clinical Guide to Laboratory Tests, Fourth Edition. Saunders Elsevier, St. Louis, Missouri. Pp. 502 510.

Hurd, R. (2006 March 8, Updated). Growth Hormone. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003706.htm. Accessed on 7/21/07.

Van Voorhees, B. (2006 June 13, Updated). Growth hormone deficiency. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/001176.htm. Accessed on 7/21/07.

Hurd, R. (2006 March 13, Updated). Growth hormone stimulation test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003377.htm. Accessed on 7/21/07.

Hurd, R. (2006 March 13, Updated). Growth hormone suppression test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003376.htm. Accessed on 7/21/07.

(2007 April). Acromegaly. NIDDK. NIH Publication No. 02-3924 [On-line information]. Available online at http://www.niddk.nih.gov/health/endo/pubs/acro/acro.htm. Accessed September 2007.

Leukemia and Lymphoma Society. Fact Sheet: Long Term and Late Effects of Treatment for Blood Cancers [Online information]. Available for download through http://www.leukemia-lymphoma.org. Accessed October 2007.

William E. Winter, MD, FACB. Lab Tests Online adjunct board member.

Eckman, A. (Updated 2010 April 20). Growth hormone test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003706.htm. Accessed October 2010.

( 1995-2010). Unit Code 8688: Growth Hormone, Serum. Mayo Clinic, Mayo Medical Laboratories [On-line information]. Available online at http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/8688. Accessed October 2010.

Meikle, W. and Roberts, W. (Updated 2010 May). Growth Hormone Deficiency. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/GrowthHormone.html?client_ID=LTD. Accessed October 2010.

( 2010). Growth Disorders Treatment Options, The Hormone Foundation [On-line information]. Available online at http://www.hormone.org/Growth/treatment.cfm. Accessed October 2010.

Savage, M. et. al. (2010 June 23). The Continuum of Growth HormoneIGF-I Axis Defects Causing Short Stature: Diagnostic and Therapeutic Challenges. Medscape Today fromClin Endocrinol. 2010;72(6):721-728. [On-line information]. Available online at http://www.medscape.com/viewarticle/722763. Accessed October 2010.

Pagana, K. D. & Pagana, T. J. ( 2007). Mosbys Diagnostic and Laboratory Test Reference 8th Edition: Mosby, Inc., Saint Louis, MO. Pp 506-508.

Wu, A. ( 2006). Tietz Clinical Guide to Laboratory Tests, 4th Edition: Saunders Elsevier, St. Louis, MO. Pp 502-503.

Kronenberg, H. et. al. ( 2008). Williams Textbook of Endocrinology, 11th Edition: Saunders Elsevier, Philadelphia, PA. Pp 857-863.

Rosenbloom, Arlan L. Sex Hormone Priming for Growth Hormone Stimulation Testing in Pre- and Early Adolescent Children Is Evidence Based.Horm Res Paediatr2011;75:7880.

Updated 2012 April 6). Acromegaly. National Endocrine and Metabolic Diseases Information Service. [On-line information]. Available online at http://www.endocrine.niddk.nih.gov/pubs/acro/acro.aspx. Accessed August 2014.

Topiwala, S. (Updated 2012 May 31). Growth hormone test. MedlinePlus Medical Encyclopedia [On-line information]. Available online at http://www.nlm.nih.gov/medlineplus/ency/article/003706.htm. Accessed August 2014.

Hammami, M. (Updated 2013 June 7). Growth Hormone. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/2089136-overview. Accessed August 2014.

Diaz-Thomas, A. et. al. (Updated 2014 May 12)). Gigantism and Acromegaly. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/925446-overview. Accessed August 2014.

Rosenbloom, A. and Guevara-Aguirre, J. (Updated 2014 January 23). Growth Hormone Resistance. Medscape Drugs & Diseases [On-line information]. Available online at http://emedicine.medscape.com/article/922902-overview. Accessed August 2014.

van Bunderen, C. et. al. (2014). Efficacy and Safety of Growth Hormone Treatment in Adults With Growth Hormone Deficiency A Systematic Review of Studies on Morbidity. Medscape News fromClin Endocrinol. 2014;81(1):1-14. [On-line information]. Available online at http://www.medscape.com/viewarticle/827774. Accessed August 2014.

Meikle, A. W. (Updated 2014 January). Growth Hormone Deficiency. ARUP Consult [On-line information]. Available online at http://www.arupconsult.com/Topics/GrowthHormone.html?client_ID=LTD#tabs=0. Accessed August 2014.

(June 7, 2013) Hammami, M. Growth Hormone. Medscape Reference. Available online at http://emedicine.medscape.com/article/2089136-overview#a30. Accessed September 2014.

Eledrisi, MS. Growth Hormone Deficiency. Medscape. Available online at http://emedicine.medscape.com/article/120767-overview. Accessed March 2015.

Kemp, S. Pediatric Growth Hormone Deficiency. Available online at http://emedicine.medscape.com/article/923688-overview. Accessed March 2015.

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Growth Hormone - Lab Tests Online

Growth hormone, athletic performance, and aging – Harvard …

Can human growth hormones really benefit aging, like the elusive fountain of youth? In 1513, the Spanish explorer Juan Ponce de Leon arrived in Florida to search for the fountain of youth. If he got any benefit from his quest, it was due to the exercise involved in the search.

Few men today believe in miraculous waters, but many, it seems, believe in the syringe of youth. Instead of drinking rejuvenating waters, they inject human growth hormone to slow the tick of the clock. Some are motivated by the claims of the "anti-aging" movement, others by the examples of young athletes seeking a competitive edge. Like Ponce de Len, the athletes still get the benefit of exercise, while older men may use growth hormone shots as a substitute for working out. But will growth hormone boost performance or slow aging? And is it safe?

As a service to our readers, Harvard Health Publishing provides access to our library of archived content. Please note the date of last review or update on all articles. No content on this site, regardless of date, should ever be used as a substitute for direct medical advice from your doctor or other qualified clinician.

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Growth hormone, athletic performance, and aging - Harvard ...

Massive Growth of Hormone Replacement Therapy Market by 2028 with Top Key Players Pfizer, Novo Nordisk, Abbott Laboratories Puck77 – Puck77

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The updated report on the Hormone Replacement Therapy market gives a precise analysis of the value chain assessment for the review period of 2021 to 2027. The research includes an exhaustive evaluation of the administration of the key market companies and their revenue-generating business strategies adopted by them to drive sustainable business. The Service industry report further enlists the market shortcomings, stability, growth drivers, restraining factors, opportunities for the projected timeframe.

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The top companies in this report include: Pfizer, Novo Nordisk, Abbott Laboratories, Novartis, Bayer Healthcare, Merck Serono, Eli Lilly, Roche, Mylan Laboratories, and Genentech.

The Global Hormone Replacement Therapy market is expected to register a notable market expansion of XX% during the review period owing to the largest market value in 2019. The market study provides a measure of the effectiveness of the product, real-time Hormone Replacement Therapy market scenario, along custom ease. The study further offers market analysis, strategies and planning, R & D landscape, target audience management, market potential, due diligence, and competitive landscape.

Scope of the report:

A thorough analysis of statistics about the current as well as emerging trends offers clarity regarding the Hormone Replacement Therapy market dynamics. The report includes Porters Five Forces to analyze the prominence of various features such as the understanding of both the suppliers and customers, risks posed by various agents, the strength of competition, and promising emerging businesspersons to understand a valuable resource. Also, the report spans the Hormone Replacement Therapy research data of various companies, benefits, gross margin, strategic decisions of the worldwide market, and more through tables, charts, and infographics.

The Hormone Replacement Therapy report highlights an all-inclusive assessment of the revenue generated by the various segments across different regions for the forecast period, 2021 to 2027. To leverage business owners, gain a thorough understanding of the current momentum, the Hormone Replacement Therapy research taps hard to find data on aspects including but not limited to demand and supply, distribution channel, and technology upgrades. Principally, the determination of strict government policies and regulations and government initiatives building the growth of the Hormone Replacement Therapy market offers knowledge of what is in store for the business owners in the upcoming years.

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The global Hormone Replacement Therapy market has been spread across North America, Europe, Asia-Pacific, the Middle East and Africa, and the rest of the world.

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COVID-19 Impact Analysis

The pandemic of COVID-19 has emerged in lockdown across regions, line limitations, and breakdown of transportation organizations. Furthermore, the financial vulnerability Hormone Replacement Therapy Market is a lot higher than past flare-ups like the extreme intense respiratory condition (SARS), avian influenza, pig influenza, bird influenza, and Ebola, inferable from the rising number of contaminated individuals and the vulnerability about the finish of the crisis. With the rapid rising cases, the worldwide Hormone Replacement Therapy refreshments market is getting influenced from multiple points of view.

The accessibility of the labor force is by all accounts disturbing the inventory network of the worldwide Hormone Replacement Therapy market as the lockdown and the spread of the infection are pushing individuals to remain inside. The presentation of the Hormone Replacement Therapy makers and the transportation of the products are associated. If the assembling movement is stopped, transportation and, likewise, the store network additionally stops. The stacking and dumping of the items, i.e., crude materials and results (fixings), which require a ton of labor, is likewise vigorously affected because of the pandemic. From the assembling plant entryway to the stockroom or from the distribution center to the end clients, i.e., application ventures, the whole Hormone Replacement Therapy inventory network is seriously compromised because of the episode.

The research provides answers to the following key questions:

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Massive Growth of Hormone Replacement Therapy Market by 2028 with Top Key Players Pfizer, Novo Nordisk, Abbott Laboratories Puck77 - Puck77

The One Diet That Will Slim Down Your Waistline, Says Dietitian | Eat This Not That – Eat This, Not That

Lose Your Gut! Blast Your Belly!The New Secrets to Flat Abs Fast!Who can resist reading about the latest technique that promises A Tighter Tummy Today!

For those who want to target the area rolls over the waistband of her jeans. Here's the problem: There's really no diet or exercise that can perform "a surgical strike," a laser-focused attack on belly fat alone. And that frustrates many people when they don't get the super-quick results many diet programs promise.

"You can't spot reduce abdominal fat," says Melissa Daniels, RD, head nutritionist, and director of managed plans for G-Plans, a science-based weight-loss and wellness company co-founded by nutritional scientist Philip Goglia, PhD. "The key to shrinking your midsection," says Daniels, "is reducing overall body fat percentage."

Daniels advocates a three-pronged diet plan that will help the majority of people who tend to hold their weight around their waists: 1. eat enough of the right combination of macronutrients to maximize your specific metabolism; 2. fill up on proteins; 3. avoid pro-inflammatory foods and choose those that fight inflammation.

Read on, and for more on how to eat healthy, don't miss 7 Healthiest Foods to Eat Right Now.

Upwards of three-quarters of the population has a fat-and-protein-efficient metabolism, according to Dr. Goglia. That means they digest fat and protein more efficiently than they do carbohydrates. So, eating a diet that's higher in protein and fat and moderate in carbohydrates should help people with this type of metabolism lose overall body fat and maintain wellbeing best.

Daniels recommends that the breakdown of macronutrients in your daily diet be 50% protein, 25% fat, and 25% carbohydrate. (Related: What To Eat in a Day To Drive the Most Weight Loss.)

"Eat most of your carbs early in the day," she says. "Most people are more active during the day, so you will want to create a fuel pattern that keeps you going throughout the day. You're not going to run a marathon at night, so you don't need a bunch of carbs with dinner." If you find it challenging to get 50 grams of protein daily, try a protein shake in the morning. Here's The #1 Best Protein Powder for Weight Loss, Says a Dietitian.

Daniels points out that high carbohydrate intake in the evening prevents the body from going into deep REM sleep, thus disrupting sleep and recovery.

Your eat-them-early carbohydrates should come from single ingredient starches such as yams, sweet potatoes, oats, oat puffs, and quinoa. Fruit and vegetables will also make up the remaining carbohydrate of the day.

READ MORE:The 20 Healthiest Low-Carb Foods

Your dinner should be your biggest protein meal of the day to rebuild the muscle you have broken down, says Daniels.

An example of an appropriate dinner would be a piece of fatty fish, like wild-caught salmon, with a side of dark leafy greens such as sauted spinach or asparagus. Fish has anti-inflammatory and fat-burning benefits when eating at nighttime; this is when your body has time to rest and repair your muscle tissue. Using high-fat fish as a dinner choice increases the amount of omega fatty acids consumed at night, the result is a deeper sleep, increased growth hormone release, and reduction of inflammation.

When planning lunch, think about supporting your afternoon energy patterns so that you don't have late-afternoon energy dips or cravings, says Daniels. So, a good lunch might consist of a starch portion (like cup of rice or four ounces of yam or potato) with a 4-ounce meat source (like a grilled chicken breast) plus a cup of spinach or beets or a salad, she suggests.

Inflammation is your body's natural reaction to invaders like plant pollen or viruses.

Persistent or chronic inflammation, however, is unhealthy, and it is most commonly triggered by the foods you eat.

Chronic inflammation has been linked to cancer, heart disease, diabetes, depression, and Alzheimer's disease. Inflammation also contributes to weight gain. Recent research has shown that inflammation can interfere with the hormone leptin that tells the brain when you've had enough to eat.

"You want to remove high inflammatory foods from your diet," says Daniels. Pro-inflammatory foods include processed bread, refined carbohydrates, fried foods, red meats, and sugar-sweetened beverages. "Consuming more of these types of foods will contribute to inflammation and distention in the abdominal region," says Daniels.

Read more: Popular Foods That Increase Inflammation, Say Dietitians

Instead, load up on foods that fight inflammation. And you can guess what they are: Fruits and vegetables, such as apples, blueberries, and leafy greens, all of which are rich in natural antioxidants and polyphenols, compounds found in plants that may protect against inflammation.

Read more: Popular Foods That Reduce Inflammation, Says Dietitian

These three diet practices won't melt your belly fat overnight, but they will begin to shrink fat cells all over your body, which you'll eventually notice when you slip on your jeans and they slip off you without a belt to hold them up. To speed up your slim down, also try these burning 40 Easy Ways to Burn Extra Calories Every Day.

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The One Diet That Will Slim Down Your Waistline, Says Dietitian | Eat This Not That - Eat This, Not That

What Is Weaver Syndrome? Tallest Woman in the World’s Height Due to Rare Condition – Newsweek

A Turkish woman has been named as the tallest living female by Guinness World Records.

Rumeysa Gelgi, who is 7 feet and 0.7 inches tall, was announced as the record holder on Wednesday. She had already been awarded the title of tallest living female teenager back in 2014 and was recently re-measured.

Her great height is due to a condition known as Weaver syndrome, Guinness World Records said in a news release.

Weaver syndrome is a condition thought to be caused by a mutation in the EZH2 gene, but it's unclear exactly why it causes people to grow so tall, according to the U.S. National Library of Medicine's MedlinePlus site.

The condition is also characterised by facial features that may include a broad forehead and large ears.

Growth and bone development in people with Weaver syndrome is faster than normal, though their weight to height relationship may be standard, according to the National Organization for Rare Disorders (NORD).

In some patients, symptoms might not show until several months after birth, but the syndrome is usually present before birth. It affects men about three times more often than women, NORD adds.

Other symptoms can include an abnormal curvature of the spine and muscle tone that is either increased or decreased. In addition, people with Weaver syndrome may have joint problems that can restrict movement, particularly in the fingers and toes.

It's unclear exactly how rare Weaver syndrome is, but there have only ever been 50 cases reported medically, according to MedlinePlus.

Some cases occur as a result of new genetic mutations in people with no history of the disorder in their familythough others inherit the mutation from a parent. Weaver syndrome can be diagnosed via a genetic test in most cases.

According to the UK-based Child Growth Foundation (CGF) charity, medical understanding of the condition and how to manage and treat it is growing all the time, though this is still limited.

The CGF focuses on support and management of rare growth conditions such as Weavers syndrome and also other conditions like Growth Hormone Deficiency, Sotos syndrome, and IGF-1 Deficiency. It aims to raise awareness of the conditions and support research into greater understanding of them.

Guinness World Records names Sultan Ksen, a Turkish farmer, as the world's tallest living man. He has been measured at 8 feet and 2.8 inches tall, due to an over-production of a growth hormone.

UPDATE 10/14/21 7:51 a.m. ET: This article was updated to include a new picture.

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What Is Weaver Syndrome? Tallest Woman in the World's Height Due to Rare Condition - Newsweek

Iodine | The Nutrition Source | Harvard TH Chan School of Public Health – HSPH News

Iodine is an essential trace mineral not made by the body so must be obtained by food or supplements. It is found naturally in some foods and is added to supplements and some salt seasonings. Iodine is needed to make the thyroid hormones thyroxine and triiodothyronine, which assist with the creation of proteins and enzyme activity, as well as regulating normal metabolism. Without enough iodine, these thyroid hormones do not work properly and can lead to an under-active or overactive thyroid gland, causing the medical conditions of hypothyroidism and hyperthyroidism with various negative side effects in the body.

RDA: The Recommended Dietary Allowance for iodine is 150 micrograms (mcg) daily for adult men and women 19+ years, and 220 and 290 mcg daily for pregnant and lactating women, respectively. [1,2]

UL: A Tolerable Upper Intake Level (UL) is the maximum daily dose unlikely to cause adverse side effects in the general population. The UL for iodine for adults 19+ years and pregnant and lactating women is 1,100 mcg daily.

Production of thyroid hormones increases during pregnancy, requiring higher intakes of iodine. Both the fetus and infant require enough iodine for normal physical growth and brain development. Breast milk contains iodine, though the amount will depend on the mothers diet, and many infant formulas contain iodine. However, not all prenatal multivitamins contain iodine. The American Academy of Pediatrics recommends that prenatal and lactating women take supplemental iodine by using iodized salt. [2] High-dose iodine supplements are not always advised, as they can cause thyroid problems in some women.

Moderate to severe iodine deficiency in children can cause a lower IQ and stunted growth. Iodine supplementation in these children appears to improve both their physical and mental development.

These conditions occur when the body produce too little (hypothyroidism) or too much (hyperthyroidism) thyroid hormone. An early sign of hypothyroidism is having an elevated blood level of of thyroid stimulating hormone (TSH). This may occur with low intakes of iodine. It may also occur in people with a history of iodine deficiency who take high doses of iodine such as in supplements. [1] Goiter, a lump in the front of the neck from an enlarged inflamed thyroid gland, can result from hypothyroidism, hyperthyroidism, or an excessive iodine intake (usually involves taking very high doses of more than 18,000 mcg a day for a prolonged time). [1] Relatedly, goitrogens in some cruciferous vegetables can prevent the absorption of iodine, which may then interfere with thyroid function and cause goiter. Those already with an iodine deficiency or hypothyroidism are most susceptible.

Iodine is found in soil and the ocean, which varies in amount and will affect how much of the mineral is contained in a food. Iodine is found mainly in animal protein foods and sea vegetables, and to a lesser extent in fortified foods like breads, cereals, and milk.

Iodine regulates metabolism, the conversion of energy obtained from food into energy to help cells function and grow. A deficiency of iodine can therefore prevent normal growth and development. This is especially dangerous in pregnant women and infants, in which miscarriage, stillbirth, stunted growth, and cognitive impairments (difficulties with reading, writing, talking, problem solving, social skills) can occur. In adults, an iodine deficiency of less than 10-20 mcg a day can lead to inadequate thyroid hormone production, called hypothyroidism, which disrupts normal metabolic functions like regulating heart rate, body temperature, and body weight. [2] A lump or swelling in the neck, called goiter, often accompanies hypothyroidism. Other signs of hypothyroidism include:

People at risk for iodine deficiency include those who do not use iodized salt or supplements containing iodine, pregnant women, vegans who do not eat any animal foods, and those living in areas with low levels of iodine in the soil (e.g., mountainous regions).

High iodine intakes are usually well-tolerated in most healthy people and do not cause problems. [1] This has been observed in countries such as Japan and Korea that eat iodine-rich seaweed regularly. [3] But some people with autoimmune thyroid disease or who have a history of chronic iodine deficiency can be sensitive to receiving extra iodine, inducing conditions of iodine deficiency like hypothyroidism and goiter. [2,4] Excess iodine can also lead to too much thyroid hormone production, causing hyperthyroidism; signs of this condition are an increased metabolism that promotes weight loss, fast or irregular heartbeat, hand tremors, irritability, fatigue, and sweatiness. Sometimes even just a slight increase in dietary iodine above the RDA can cause iodine-induced hyperthyroidism in sensitive individuals. [4]

Some epidemiologic studies have shown that high seaweed intakes are associated with an increased risk of certain types of thyroid cancer, particularly in postmenopausal women, but the exact mechanism is unclear. [2,3]

Excess iodine intake may come from use of high-dose supplements or overeating certain seaweeds and salts that contain iodine. Severe iodine poisoning is rare, but symptoms include fever; stomach pain; nausea; vomiting; a burning sensation of the mouth, throat, and stomach; and even coma. [2] Children, infants, the elderly, and those with existing thyroid disease are particularly vulnerable to iodine toxicity and iodine-induced hypothyroidism and hyperthyroidism. [3,4]

Vitamins and Minerals

The contents of this website are for educational purposes and are not intended to offer personal medical advice. You should seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The Nutrition Source does not recommend or endorse any products.

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Hormone Replacement Therapy Market To grow At a Strong CAGR Of 8.20% In Healthcare Industry||Abbott Laboratories, Novo Nordisk, Novartis, Merck…

Hormone Replacement Therapy Market is valued at USD 21.04 Billion in 2020 and expected to reach USD 36.54 Billion by 2027 with the CAGR of 8.20% over the forecast period.

The information made available in the Hormone Replacement Therapy report will definitely facilitate to increase the knowledge and decision-making skills of the business, thus providing an immense opportunity for growth. This will at last increase the return rate and drive the competitive edge within. Being a custom market report, it provides services tailored to the exact challenge. Whether it is survey work, in-depth interviewing, or a combination of multiple methods, marketing report will match the right methodology and personnel to the business need. Proficient team of analysts gather, analyze, and synthesize the data to accomplish challenging tasks while not setting unrealistic expectations.

The report focuses on the major players that are in operation within the market and their competitive landscape present in the market. The report includes an inventory of initiatives taken by the businesses within the past years. The report has mentioned growth parameters in the regional markets along with major players dominating the regional growth such as North America, Europe, China, Japan, Southeast Asia and India.

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Key Players for Hormone Replacement Therapy Market

Global Hormone Replacement Therapy report covers prominent players Abbott Laboratories, Novo Nordisk, Novartis, Merck Serono, Bayer Healthcare, Eli Lilly, Mylan Laboratories, Roche, Genentech, Orion Pharma AB, Allergen Plc and others.

Global Hormone Replacement Therapy Market Segmentation:

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Hormone Replacement Therapy Market Scenario

The report throws light on the competitive landscape, segmentation, geographical expansion, and revenue, production, and consumption growth of the Hormone Replacement Therapy market. Hormone Replacement Therapy Market Size, Growth Analysis, Industry Trend, and Forecast, offers details of the factors influencing the global business scope. This report provides future products, joint ventures, marketing strategy, developments, mergers and acquisitions, marketing, promotions, revenue, import, export, CAGR values, the industry as a whole, and the particular competitors faced are also studied in the large-scale market.

Hormone Replacement Therapy Market competitive landscape provides details by competitor. Details included are company overview, company financials, revenue generated, market potential, investment in research and development, new market initiatives, production sites and facilities, company strengths and weaknesses, product launch, product trials pipelines, product approvals, patents, product width and breath, application dominance, technology lifeline curve. The data points provided are only related to the companys focus related to Hormone Replacement Therapy market. Leading global Hormone Replacement Therapy market players and manufacturers are studied to give a brief idea about competitions.

Latest news and industry developments in terms of market expansions, acquisitions, growth strategies, joint ventures and collaborations, product launches, market expansions etc. are included in the report. The report focuses on the operation and their competitive landscape present within the market. Identification of numerous key players of the market will help the reader perceive the ways and collaborations that players will need to understand the competition within the global Hormone Replacement Therapy market.

Hormone Replacement Therapy Market report provides depth analysis of the market recent developments and comprehensive competitive landscape created by the COVID19/CORONA Virus pandemic. Hormone Replacement Therapy Market report is helpful for strategists, marketers and senior management, And Key Players in Hormone Replacement Therapy Industry.

Market Dynamics Of Hormone Replacement Therapy Market

Global Hormone Replacement Therapy market report has the best research offerings and the required critical information for looking new product trends or competitive analysis of an existing or emerging market. Companies can sharpen their competitive edge again and again with this business report. The report comprises of expert insights on global industries, products, company profiles, and market trends. Users can gain unlimited, company-wide access to a comprehensive catalog of industry-specific market research from this industry analysis report. The market report examines industries at a much higher level than an industry study.

Table of Content: Global Hormone Replacement Therapy Market Research Report

Chapter 1: Global Hormone Replacement Therapy Industry Overview

Chapter 2: Global Economic Impact on Hormone Replacement Therapy Market

Chapter 3: Global Market Size Competition by Industry Producers

Chapter 4: Global Productions, Revenue (Value), according to Regions

Chapter 5: Global Supplies (Production), Consumption, Export, Import, geographically

Chapter 6: Global Productions, Revenue (Value), Price Trend, Product Type

Chapter 7: Global Market Analysis, on the basis of Application

Chapter 8: Hormone Replacement Therapy Market Industry Value Chain

Chapter 9: Hormone Replacement Therapy Market Chain, Sourcing Strategy, and Downstream Buyers

Chapter 10: Strategies and key policies by Distributors/Suppliers/Traders

Chapter 11: Key Economic Indicators, by Market Vendors

Chapter 12: Market Effect Factors Analysis

Chapter 13: Global Hormone Replacement Therapy Market Forecast Period

Chapter 14: Future Of The Market

Chapter 15: Appendix

Substantial research & development activities carry out by some players that comprises offering training to covering recent information on new technology, materials and techniques to innovative practice solutions, will complement the market growth is also explained. Frequent technological advances, superior portability, and ease of handling for Hormone Replacement Therapy are boosting adoption in home and alternate care settings as well. Furthermore, non-profit and government initiatives, and awareness programs, and an influx of funding for research studies have positively influenced developments within the industry.

Global Hormone Replacement Therapy Market: Regional Analysis

The research report includes specific segments by region (country), by company, by Type and by Application. This study provides information about the sales and revenue during the historic and forecasted period of 2021 to 2027. Understanding the segments helps in identifying the importance of different factors that aid the market growth.

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Hormone Replacement Therapy Market To grow At a Strong CAGR Of 8.20% In Healthcare Industry||Abbott Laboratories, Novo Nordisk, Novartis, Merck...

Growth hormone | You and Your Hormones from the Society …

Alternative names for growth hormone

Somatotropin; GH; human growth hormone; HGH

Growth hormone is released into the bloodstream from the anterior pituitary gland. The pituitary gland also produces other hormones that have different functions from growth hormone.

Growth hormone acts on many parts of the body to promote growth in children. Once the growth plates in the bones (epiphyses) have fused growth hormone does not increase height. In adults, it does not cause growth but it helps to maintain normal body structure and metabolism, including helping to keep blood glucose levels within set levels.

Growth hormone release is not continuous; it is released in a number of bursts or pulses every three to five hours. This release is controlled by two other hormones that are released from the hypothalamus (a part of the brain): growth hormone-releasing hormone, which stimulates the pituitary to release growth hormone, and somatostatin, which inhibits that release.

Growth hormone levels are increased by sleep, stress, exercise and low glucose levels in the blood. They also increase around the time of puberty. Growth hormone release is lowered in pregnancy and if the brain senses high levels of growth hormone or insulin-like growth factors already in the blood.

Not surprisingly, too much growth hormone causes too much growth. In adults, excessive growth hormone for a long period of time produces a condition known as acromegaly, in which patients have swelling of the hands and feet and altered facial features. These patients also have organ enlargement and serious functional disorders such as high blood pressure, diabetes and heart disease. Over 99% of cases are due to benign tumours of the pituitary gland, which produce growth hormone. This condition is more common after middle-age when growth is complete so affected individuals do not get any taller.

Very rarely, increased growth hormone levels can occur in children before they reach their final height, which can lead to excessive growth of long bones, resulting in the child being abnormally tall. This is commonly known as gigantism (a very large increase in height).

Overproduction of growth hormone is diagnosed by giving a sugary drink and measuring the growth hormone level over the next few hours. The sugar should cause growth hormone production to reduce. However, this does not happen in acromegaly.

Too little growth hormone (deficiency) results in poor growth in children. In adults, it causes a reduced sense of wellbeing, increased fat, increased risk of heart disease and weak heart, muscles and bones. The condition may be present from birth where the cause can be unknown, genetic or due to injury to the pituitary gland (during development or at birth).

Growth hormone deficiency may also develop in adults due to brain injury, a pituitary tumour or damage to the pituitary gland (for example, after brain surgery or radiotherapy for cancer treatment). The main treatment is to replace the growth hormone using injections - either once a day or several times a week.

In the past, growth hormone treatment was stopped at the end of growth. It is now clear that growth hormone contributes to both bone mass and muscle mass reaching the best possible level, as well as reducing fat mass during development to an adult. The specialist is therefore likely to discuss the benefits of continuing growth hormone after growth has completed until age 25 to make sure bone and muscle mass reach the best possible level. Additionally, growth hormone has been linked to a sensation of wellbeing, specifically energy levels. There is evidence that 30-50% of adults with growth hormone deficiency feel tired to a level that impairs their wellbeing. These adults may benefit from lifelong treatment with growth hormone. Taking growth hormone when adult will not result in increased height.

Last reviewed: May 2021

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Growth hormone | You and Your Hormones from the Society ...