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What is growth hormone deficiency?

Growth hormone deficiency (GHD), also known as dwarfism or pituitary dwarfism,is a condition caused by insufficient amounts of growth hormone in the body. Children with GHD have abnormally short stature with normal body proportions. GHD can be present at birth (congenital) or develop later (acquired). The condition occurs if the pituitary gland makes too little growth hormone. It can be also the result of genetic defects, severe brain injury or being born without a pituitary gland. In some cases, there is no clear cause identified. Sometimes, GHD can be associated with lower levels of other hormones, such as vasopressin (which controls water production in the body), gonadotropins (which controls the production of male and female sex hormones), thyrotropins (which control the production of thyroid hormones) or adrenocorticotrophic hormone (which controls the adrenal gland and related hormones).

Slow growth or absence of growth

Short stature (below the fifth percentile compared to other children of the same age and sex)

Absent or delayed sexual development during puberty

Headaches

Symptoms of other pituitary hormone deficiencies that may co-exist with growth hormone deficiency:

Absent or delayed sexual development during puberty

Increased urination and amount of urine

Excessive thirst

Facial abnormalities can be present in a small group of children with GHD, typically caused by pituitary defects.

A physical exam and measurement of height, weight, arms and leg lengths are the first steps to diagnosis, in addition to thorough medical history. Blood tests to measure the levels of growth hormone in the body as well as the levels of other hormones. Imaging tests including X-rays and MRI of the head may be helpful in narrowing down the underlying disorder causing GHD by revealing abnormalities of the hypothalamus or the pituitary glands.

Some cases of GHD can be treated with the use of synthetic growth hormone under the supervision of a pediatric endocrinologist. If other hormone deficiencies exist, other hormones can be given in addition to synthetic growth hormone.

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Growth Hormone Deficiency | Johns Hopkins Medicine

Having a good height is nothing less than a blessing. Being tall is one of the elements of a perfect physical appearance which also creates a lasting impression on others. Call yourself lucky if you are blessed with it. Anywhere between 5 feet 6 inches and above is often considered a good height for females. For males, it is somewhere between 5 feet 8 inches and above.

You will be baffled to know that there is a person who stands around 8 feet tall. Yes, you heard that right. He is the tallest person in the world.

The Guinness World Records named Sultan Kosen the tallest person in the world. He is the first-ever man who stands over 8 feet tall out of the ten confirmed and reliable cases in the history of human existence. Sultan is a part-time farmer from Turkey. When he took the iconic title of the Tallest living man, he measured 8 feet 1 inch.

Two years later, Sultan turned 26 years old. He was measured again in Ankara. By that time, his height went up to 8 feet 2.8 inches.

Sultan was born on 10th December 1982. Interestingly, he did not start his incredible growth spurt until he turned 10 years old. The rest of his family, including his parents and four siblings, have an average height. Due to his gigantic size, Sultan could never finish his school. He, however, started working as a farmer to support his family.

Sultans unique growth and massive height are caused by the condition known as pituitary gigantism. It is the result of the overproduction of growth hormones.

Human growth hormone is released from the pituitary gland in the brain. If the gland is damaged by a tumor, it may release too much or too little hormone. When released too much, the condition may lead to overproduction of large hands, painful joints, and thickening of the bones.

In an interview, Sultan funnily described that being tall has its advantages. He can help his mother out with daily jobs and chores such as hanging curtains, changing a broken bulb, and others. However, the condition comes with many disadvantages too. It becomes challenging to find the right size of shoes and clothes or even to drive a car, for that matter.

Apart from being the tallest man in the whole wide world, Sultan Koser has other records in his name. He holds the title of living person with the largest hands. Each of his hands measures 28.5 centimeters from the wrist to the tip of the middle finger.

Previously, he held the title for the largest foot on a living person. His left foot measured 36.5 centimeters, and his right one measured 35.5 centimeters.

On a personal front, Sultan is married to Merve Dibo. His wife is nine years younger than him and stands 5 feet 9 inches tall. They met through a mutual friend.

Ever since he has become the record-holder of the Guinness World Records, Sultan has accomplished many of his dreams. He received life-saving medical treatment to stop himself from growing further. He also swapped his farming for Hollywood and bagged a role in the movie, Achieving the Impossible in 2016.

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Who is the Tallest Living Man in the World? Meet Sultan Ksen - TheTealMango

When faced with conditions that are too dry, salty, or cold, most plants try to conserve resources. They send out fewer leaves and roots and close up their pores to hold in water. If circumstances dont improve, they eventually die.

Schrenkiella parvula is a plant that can grow even thrive in extremely salty conditions. Researchers in the Dinneny Lab study this plant to understand this special adaptation, and how they might be able to modify other plants to withstand similarly stressful environments. (Image credit: Jos Dinneny)

But some plants, known as extremophytes, have evolved to handle harsh environments. Schrenkiella parvula, a scraggly, branching member of the mustard family, doesnt just survive in conditions that would kill most plants it thrives in them. It grows along the shores of Lake Tuz in Turkey, where salt concentrations in the water can be six times higher than in the ocean. In a recent paper published in Nature Plants, researchers at Stanford University found that Schrenkiella parvula actually grows faster under these stressful conditions.

Most plants produce a stress hormone that acts like a stop signal for growth, said Jos Dinneny, an associate professor of biology at Stanford, who is senior author of the paper. But in this extremophyte, its a green light. The plant accelerates its growth in response to this stress hormone.

Dinneny and his colleagues are studying Schrenkiella parvula to better understand how some plants cope with challenging conditions. Their findings could help scientists engineer crops that are able to grow in lower-quality soil and adapt to the stresses of climate change.

With climate change, we cant expect the environment to stay the same, said Ying Sun, a postdoctoral researcher at the Salk Institute who earned her doctorate at Stanford and is a lead author on the paper. Our crops are going to have to adapt to these rapidly changing conditions. If we can understand the mechanisms that plants use to tolerate stress, we can help them do it better and faster.

Schrenkiella parvula is a member of the Brassicaceae family, which contains cabbage, broccoli, turnips, and other important food crops. In areas where climate change is expected to increase the duration and intensity of droughts, it would be valuable if these crops were able to weather or even thrive in those dry spells.

When plants encounter dry, salty, or cold conditions all of which create water-related stress they produce a hormone called abscisic acid, or ABA. This hormone activates specific genes, essentially telling the plant how to respond. The researchers examined how several plants in the Brassicaceae family, including Schrenkiella parvula, responded to ABA. While the other plants growth slowed or stopped, the roots of Schrenkiella parvula grew significantly faster.

Schrenkiella parvula is closely related to the other plants in the study and has a very similar-sized genome, but ABA is activating different sections of its genetic code to create a completely different behavior.

That rewiring of that network explains, at least partially, why were getting these different growth responses in stress-tolerant species, Dinneny said.

Image of an S. parvula root taken with a confocal microscope. (Image credit: Prashanth Ramachandran)

An overview of Ying Suns research by Neil E. Robbins II, PhD 17, a former graduate student in the Dinneny Lab. This comic was originally released April 14, 2017, on Neiler Comics. (Image credit: Neil E. Robbins II)

Understanding this stress response and how to engineer it in other species could help more than just food crops, Dinneny said. Schrenkiella parvula is also related to several oilseed species that have the potential to be engineered and used as sustainable sources of jet fuel or other biofuels. If these plants can be adapted to grow in harsher environmental conditions, there would be more land available for cultivating them.

You want to be growing bioenergy crops on land that is not suitable for growing food say, an agricultural field that has degraded soil or has accumulated salinity because of improper irrigation, Dinneny said. These areas are not prime agricultural real estate, but land that would be abandoned otherwise.

Dinneny and his colleagues are continuing to investigate the network of responses that could help plants survive in extreme conditions. Now that they have an idea of how Schrenkiella parvula sustains its growth in the face of limited water and high salinity, they will try to engineer related plants to be able to do the same by tweaking which genes are activated by ABA.

Were trying to understand what the secret sauce is for these plant species what allows them to grow in these unique environments, and how we can use this knowledge to engineer specific traits in our crops, Dinneny said.

Additional Stanford co-authors of this research include research associate Lina Duan, postdoctoral scholar Prashanth Ramachandran, and graduate student Andrea Ramirez. Other coauthors are from Louisiana State University and the Salk Institute for Biological Studies. Dinneny is a member of Stanford Bio-X.

This work was funded by the U.S. Department of Energy, the Carnegie Institution for Science, the National Science Foundation, the Rural Development Association of South Korea, and the HHMI-Simons Faculty Scholars program.

To read all stories about Stanford science, subscribe to the biweeklyStanford Science Digest.

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'Extreme' plants grow faster in the face of stress | Stanford News - Stanford University News

Published April 28, 2022 by PETA.

Why drink cows milk thats meant for baby cows when you can drink a healthier, kinder milk option? Almond milk is better not only for your health but also for animals. So if you want to help save cows, stay healthy, and reduce your carbon footprint, heres everything that you need to know about the benefits of almond milk and how to make it at home.

The simple answer is yesalmond milk has less of an impact on our planet than cows milk. At 396 grams of carbon dioxide (CO2) produced per liter, it has a smaller carbon footprint than cows milk, which produces 1,467 grams of CO2. Trees, which absorb the CO2 that exacerbates the climate catastrophe, are planted to produce this vegan milk. Almond milk also requires less water to produce than cows milk. No matter how you compare them, cows milk is the worse optionand any vegan milk is a better choice for the planet.

Dont miss out on the health benefits that almond milk has. Since it has fewer calories than cows milk, it can help you maintain a healthy weight reduce the risk of developing cancer, and improve cholesterol levels. Cows milk is also bad for bone health. A study published in the American Journal of Public Health of more than 77,000 women ages 34 to 59 found that those who consumed two or more glasses of cows milk per day had a higher risk of sustaining broken hips and arms than those who drank one glass or less per day.

Cows milk leaches calcium from our bones: When animal proteins break down, acids form. Because calcium is a good acid neutralizer, our body uses the calcium in milk to neutralize these acids. If you want high-quality calcium that will strengthen your bones, choose fortified almond milk.

Cows milk also contains many added hormones. In order to produce unnaturally large volumes of milk, cows are injected with recombinant bovine growth hormone, or rBGH, which puts them at increased risk of developing mastitis, a painful inflammation of the udder. Almond milk contains no added hormonesand if you buy organic almonds and make it yourself, the only ingredients are almonds and water!

Just like human mothers do, cows produce milk for their babies. Cows used for their milk are violently impregnated and forced to give birth repeatedly. Mothers cry out when farmers rip their babies away from them. Male calves are typically torn away from their mothers sides shortly after birth, locked in a veal crate, and killed before their first birthday. Female cows are stuck in the same cycle of abuse as their mothers. When you drink almond milk, you choose kindness.

Butter, yogurt, cheese, and other products made from cows milk cant hold a candle to their almond milk equivalents. We love all of Kite Hills almond milkbased products, including cream cheese, sour cream, and spreadable cheese.

One of the best things about almond milk is that its super-easy to make at home! Heres a quick recipe for a delicious fresh batch: Simple Vegan Blogs Almond Milk.

*****

Now that you know the many benefits of almond milk, make the switch by choosing it for your latte instead of cows milk. Ask Starbucks to end its vegan milk upcharge, which punishes people for making the choice thats better for animals, the planet, and their health:

Urge Starbucks to Stop Charging Extra for Vegan Milk!

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What Are the Health Benefits of Almond Milk? - PETA

Fast food chains are not exactly known for having the highest quality food, but some businesses are trying to change that. In fact, many chains these days use top-tier ingredients that differentiate them from the Burger King's of the world.

So what does "high-quality" food mean? According to the Harvard School of Public Health, "High-quality foods include unrefined, minimally processed foods such as vegetables and fruits, whole grains, healthy fats and healthy sources of proteinthe foods recommended in the Healthy Eating Plate."

Certain fast food chains pride themselves on simple ingredientsno artificial preservatives, colors, or flavors. And unlike the sketchy leftover burger patties in Wendy's chili, there are no secret ingredients here.

Moreover, fast food chains that advocate for simple ingredients are transparent about it on their websites and ordering systems so that customers know exactly what they're eating.

Read on to find out which chains use the highest quality ingredients, and next, check out One Ingredient Everyone's Adding to Their Burgers.

Given Panera's mission"One Panera for a Healthier and Happier World"it's no surprise that the chain serves up quality eats. In 2015, Panera published their "No No List," which bans the use of artificial ingredients. "We simply don't think that we need those ingredients to make great tasting food," Sara Burnett, Head of Panera Food Beliefs and Sustainability, told Eat This, Not That! exclusively. Even as the food chain expanded their Mac & Cheese menu options, they kept all ingredients 100% clean.

Burnett explained that there's a lot that goes on behind the scenes to guarantee clean menu items. For example, Panera had to find new ways to keep the colors of their fan-favorite, hand-decorated shortbread cookies vibrant throughout the day. Their spring Tulip Cookie uses Vegetable Glycerine, Red Beet Concentrate, and Annatto to get that bright pink color. Other chains still use ingredients on Panera's "No No List" for color in their bakery sweets, like the Red Velvet Loaf at Starbucks, which contains the Panera-banned ingredient Maltodextrin. "The simplest ingredients often taste betterIt is all rooted in putting the best tasting food on the plate," Burnett explained.

The "You Pick Two" restaurant also found new ways to preserve their proteins that don't have binding agents and artificial preservatives, added Burnett, turning to celery salt, rosemary extract, and freezing. It's no surprise that they got a Grade A- in the 2021 Chain Reaction VI Report for antibiotic use, ranking above many chains.

Panera also changes its menu seasonally to avoid using artificial ingredients, focusing instead on what's fresh. "This is why, much to some folks' disappointment, we sell the Strawberry Poppyseed Salad in the summer intentionally. We use strawberries in the summer when we know they're going to be amazing. We change our menu five times a year so we are using the best ingredients of the season," said Burnett.

And, if not already obvious, Panera is transparent about what's in their food. They are actually the first national restaurant company to display the whole grain contents of bread on its menu.

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Across Chipotle's entire menu, the chain only uses 53 real ingredients to prepare all of its food. "This is in stark contrast to most other fast-food chains where a single menu item can contain 40 or more ingredientsmany of which are added flavors, colors, preservatives, and other industrial additives," Chipotle explained on its website. And the fast-food Mexican joint is super transparent about it, creating a resource for customers to see each and every ingredient and how it's used in their menu items.

In fact, in 2017, Chipotle announced a new tortilla recipe that only contained two to five ingredients. The flour tortillas now have only flour, water, canola oil, salt, and yeast. Even down to reducing antibiotic use in meat, Chipotle is Grade A, top-ranked, according to the 2021 Chain Reaction VI Report.

The company all about "being real" was actually the first national restaurant brand to use no added colors, flavors, or preservatives in food. And much like Panera, Chipotle credits its decisions, in part, to making the best-tasting dishes: "Because we prepare our fresh food using classic cooking techniques, we avoid using the industrial additives typically associated with fast food but most importantly, that approach is the reason our food is so delicious," said Mark Crumpacker, former Chief Marketing and Development Officer for Chipotle, on their website.

Shake Shack is open about its commitment to real and natural ingredients. Their mission, "Stand for Something Good," led them to think carefully and responsibly about what goes into their food and where it comes from.6254a4d1642c605c54bf1cab17d50f1e

Their frozen custard uses only real sugar, in contrast to many other chains, like Chick-fil-A, that include high fructose corn syrup in their shakes. And while some chains like McDonald's are working towards an antibiotic-free policy, Shake Shack already excludes hormones and antibiotics from beef, chicken, pork, and hot dogs.

The crinkle-cut fry connoisseur also uses cage-free eggs, milk from dairy farmers who pledge not to use artificial growth hormones, and a non-GMO potato bun. The chain has recently expanded their vegetarian options as well, using only premium, real ingredients. All of their simple, non-artificial ingredient efforts are summarized in their "Stand for Something Good 2020" deck.

According to their mission statement, Sweetgreen is all about "building healthier communities by connecting people to real food." The company was actually funded by college students looking for healthier food that they could grab and go.

"We really focused on creating a farm-to-table experience and educating customers that their food's locally sourced," Sweetgreen explains in their story YouTube video. Sweetgreen's menu emphasizes fresh, plant-forward, earth-friendly food that uses the simplest ingredients to whip up warm bowls and salads.

Much like Chipotle, Sweetgreen's menu features limited ingredients, unlike the long list of ingredients you'll find at other food chains. The only added sugars in select menu items are maple syrup, palm sugar, and honey, but you won't find high fructose syrup or any artificial flavors. All of Sweetgreen's ingredients are outlined for customers to easily view.

BurgerFi is a rising burger chain that's changing the game when it comes to quality in the fast food industry. According to their website, "BurgerFi was founded by gourmet chefs committed to serving the highest quality fresh food in an eco-friendly environment."

BurgerFi was even recently named "America's favorite fast-casual burger chain," according to a survey, and for good reason: quality. The chain uses 100% natural American Angus Beef with no steroids, antibiotics, or artificial growth hormones. They also have Wagyu Beef, cage-free Chicken, and plant-based innovation VegeFi Burger and Beyond Meat Burgerusing simple, real, and fresh ingredients.

Added chemicals or artificial additives are not a part of BurgerFi's philosophy, which is in part why their beef was rated Grade A, once again, in the annual Chain Reaction Report.

With a prohibited ingredients list since 2015, Noodles & Company has long been committed to high-quality food. The fast-food noodles joint does not use any artificial colors, flavors, sweeteners, or preservatives across its core menu.

Noodles & Company is committed to clean ingredients, working with 14 fresh vegetables prepared daily. They also use cage-free eggs, antibiotic-free and hormone-free bacon, and organic milk and tea.

While some fast food companies are all about "secret" ingredients, like In N Out's secret sauce, Noodles & Company boasts: "Our secret ingredient? No secrets." Transparency is keythey keep their ingredients simple, real, and readily available for customers to see.

Working towards a completely clean menu by 2023, QDOBA is committed to high-quality food. "We want to feed our guests the way we feed our families; with high-quality ingredients, we feel good about," Chef Katy, QDOBA's corporate executive chef, told Eat This, Not That! exclusively.

The chain already has a running list of ingredients that they pledge to avoid. All flavor combos across its menu are free of colors from artificial sources, high fructose corn syrup, added MSG, partially hydrogenated oil, and lard. "The ingredients we avoid are always provided to our suppliers prior to developing new products to ensure the ingredients are clean," said Chef Katy.

QDOBA is all about serving up fresh, well-prepared foods, and they work hard behind the scenes to guarantee top-quality dishes: "High-quality food also has to do with the care we take to prepare it; from chopping fresh produce, to making hand-crafted guacamole, to flame-grilling antibiotic-free chicken, a lot of our preparation is done in our restaurant kitchens to ensure we are offering the best flavor and quality," added Chef Katy.

Want to know more about leading food chains in the industry? Check out This is the Best Fast Food Chain, According to Gen-Z.

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7 Fast-Food Chains That Use the Highest Quality Ingredients Eat This Not That - Eat This, Not That

The Brainy Insights aims to increase firms business acumen by giving functional and actionable insights with valuable data in Global Hormone Replacement Therapy Market. To satisfy the clients objectives of high-quality customized output in a short period, the organization has a robust collection, analytical, interpretational, and forecasting methodology for information extraction. The data analysis methods facilitate the synthesis of raw data into information utilized for factual analysis resulting in better decision-making.

Request Sample of COVID-19 Outbreak-Global Hormone Replacement Therapy Report @ https://www.thebrainyinsights.com/enquiry/sample-request/12564

Quantitative analysis is based on historical and forecast years, with 2021 as the base year. Exhaustive methodologies gather the forecasted data from global and regional markets. The interpretation and analysis of raw data are performed in line with the buyers objectives. The holistic interpretation according to clients requirements will answer the most crucial market questions that are important in business decision-making.

The different qualitative tools used in the Hormone Replacement Therapy market include PESTEL analysis, PORTERS five forces, and SWOT analysis, for determining various attributes such as the opportunities and threats of new market entrants in the industry, the pricing and bargaining power of the buyers and the sellers, availability of substitute goods or services, and the market penetration of already established sellers in the market and the presence of suppliers and vendors.

Key Components of the Hormone Replacement Therapy Market

The report consists of a segmentation analysis, regional analysis, and company profiling section. The operating segments of the Hormone Replacement Therapy market are as follows:

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The global market has been segmented into the following regions, witnessing high demand and the presence of key players. These locations include: North America (United States, Canada & Mexico)

Asia-Pacific (Japan, China, India, Southeast Asian Countries & Australia etc)

Europe (Germany, UK, France, Italy, Spain, Russia, Netherlands & Belgium etc)

Central & South America (Brazil, Argentina, LATAM etc)

Middle East & Africa (United Arab Emirates, Qatar, Saudi Arabia, Israel & South Africa etc)

All prominent participants in the Hormone Replacement Therapy market are investigated, and their business models and revenue segmentation are evaluated. The key vendors profiled in the Hormone Replacement Therapy market include Abbott Laboratories, Novartis, Pfizer, Inc., Mylan Laboratories, Merck and Co., Novo Nordisk, Bayer Healthcare, Eli Lilly, Genentech

About The Brainy Insights:

The Brainy Insights is a market research company, aimed at providing actionable insights through data analytics to companies to improve their business acumen. We have a robust forecasting and estimation model to meet the clients objectives of high-quality output within a short span of time. We provide both customized (clients specific) and syndicate reports. Our repository of syndicate reports is diverse across all the categories and sub-categories across domains. Our customized solutions are tailored to meet the clients requirement whether they are looking to expand or planning to launch a new product in the global market.

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Global Hormone Replacement Therapy Masks Market 2022 Growth, Share, Trend, Segmentation and Forecast to 2028 themobility.club - themobility.club

Proteins that are designed and engineered in the laboratory for pharmaceutical interventions to treat different diseases are known as protein therapeutics.The global protein therapeutics market accounted for $140,109 million in 2016, and is anticipated to reach $217,591 million by 2023, registering a CAGR of 6.5% from 2017 to 2023.

Market Statistics:

The file offers market sizing and forecast throughout 5 primary currencies USD, EUR GBP, JPY, and AUD. It helps corporation leaders make higher choices when foreign money change records are available with ease. In this report, the years 2020 and 2021 are regarded as historic years, 2020 as the base year, 2021 as the estimated year, and years from 2022 to 2030 are viewed as the forecast period.

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In order to produce a holistic assessment of the market, a variety of factors is considered, including demographics, business cycles, and microeconomic factors specific to the market under study. Protein Therapeutics Marketreport 2021 also contains a comprehensive business analysis of the state of the business, which analyzes innovative ways for business growth and describes critical factors such as prime manufacturers, production value, key regions, and growth rate.

The Centers for Medicare and Medicaid Services report that US healthcare expenditures grew by 4.6% to US$ 3.8 trillion in 2019, or US$ 11,582 per person, and accounted for 17.7% of GDP. Also, the federal government accounted for 29.0% of the total health expenditures, followed by households (28.4%). State and local governments accounted for 16.1% of total health care expenditures, while other private revenues accounted for 7.5%.

This study aims to define market sizes and forecast the values for different segments and countries in the coming eight years. The study aims to include qualitative and quantitative perspectives about the industry within the regions and countries covered in the report. The report also outlines the significant factors, such as driving factors and challenges, that will determine the markets future growth.

In principle, protein therapy is similar to gene therapy, and involves protein delivery in specific amounts to the body to aid in precise functioning of different glands and other organs in the body. Protein therapeutics play a pivotal role in treatment of an array of different diseases such as diabetes, lymphoma, hepatitis, and others.

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Surge in prevalence of chronic diseases and rise in development of plasma-derived therapies supplement the market growth. However, stringent government regulations towards protein therapeutics and high treatment costs per patient impede the market growth. Conversely, increase in novel indications for known protein therapeutics and untapped emerging markets offer lucrative opportunities for the market players.

The protein therapeutics market is segmented based product, application, and geography. By product, the market is divided into monoclonal antibodies, insulin, fusion protein, erythropoietin, interferon, human growth hormone, and follicle stimulating hormone. On the basis of application, it is classified into metabolic disorders, immunologic disorders, hematological disorders, cancer, hormonal disorders, genetic disorders, and others. Geographically, it is analyzed across North America, Europe, Asia-Pacific, and LAMEA.

The report provides extensive competitive analysis and profiles of key marketplayers, such as Abbott Laboratories, Amgen Inc., Baxter International Inc., Eli Lilly and Company, F. Hoffmann-La Roche Ltd., Johnson & Johnson, Merck & Co., Inc., Novo Nordisk A/S, Pfizer Inc., and Sanofi. Other players (profiles not included in the report) in the value chain analysis include, Biogen, Inc., CSL Behring, and Genentech, Inc.

KEY MARKET BENEFITS

The study provides an in-depth analysis of the global protein therapeutics market along with the current trends and future estimations to elucidate the imminent investment pockets.The report presents quantitative analysis of the market from 2017 to 2023 to enable stakeholders to capitalize on the prevailing market opportunities.Extensive analysis of the market based on application assists in understanding the trends in the industry.Key market players along with their strategies are thoroughly analyzed to understand the competitive outlook of the industry.

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Market Segment Analysis:The document provides a primary review of the industry along with definitions, classifications, and enterprise chain shape. Market analysis is furnished for the worldwide markets which include improvement tendencies, aggressive panorama evaluation, and key regions development reputation. Development policies and plans are discussed in addition to manufacturing strategies and fee systems are also analyzed. This file additionally states import/export consumption, supply and demand, charge, sales and gross margins.

KEY MARKET SEGMENTS

By Product

Monoclonal AntibodiesInsulinFusion ProteinErythropoietinInterferonHuman Growth HormoneFollicle Stimulating Hormone

By Application

Metabolic DisordersImmunologic DisordersHematological DisordersCancerHormonal DisordersGenetic DisordersOthers

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By Geography

North AmericaU.S.CanadaMexicoEuropeGermanyFranceUKItalySpainRest of EuropeAsia-PacificJapanChinaAustraliaIndiaSouth KoreaTaiwanRest of Asia-PacificLAMEABrazilSaudi ArabiaSouth AfricaRest of LAMEA

Table of Content:

Key Questions Answered in the Market Report

How did the COVID-19 pandemic impact the adoption of by various pharmaceutical and life sciences companies? What is the outlook for the impact market during the forecast period 2021-2030? What are the key trends influencing the impact market? How will they influence the market in short-, mid-, and long-term duration? What is the end user perception toward? How is the patent landscape for pharmaceutical quality? Which country/cluster witnessed the highest patent filing from January 2014-June 2021? What are the key factors impacting the impact market? What will be their impact in short-, mid-, and long-term duration? What are the key opportunities areas in the impact market? What is their potential in short-, mid-, and long-term duration? What are the key strategies adopted by companies in the impact market? What are the key application areas of the impact market? Which application is expected to hold the highest growth potential during the forecast period 2021-2030? What is the preferred deployment model for the impact? What is the growth potential of various deployment models present in the market? Who are the key end users of pharmaceutical quality? What is their respective share in the impact market? Which regional market is expected to hold the highest growth potential in the impact market during the forecast period 2021-2030? Which are the key players in the impact market?

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About Report Ocean:We are the best market research reports provider in the industry. Report Ocean believes in providing quality reports to clients to meet the top line and bottom line goals which will boost your market share in todays competitive environment. Report Ocean is a one-stop solution for individuals, organizations, and industries that are looking for innovative market research reports.

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Protein Therapeutics Market Insights with Statistics and Growth Prediction (2021-2030) Queen Anne and Mangolia News - Queen Anne and Mangolia News

This article was originally published here

Mol Cancer Ther. 2022 May 2:molcanther.0899.2021. doi: 10.1158/1535-7163.MCT-21-0899. Online ahead of print.

ABSTRACT

Triple-negative breast cancer (TNBC) is a highly aggressive type of breast cancer. Unlike other subtypes of breast cancer, TNBC lacks hormone and growth factor receptor targets. Colchicine-binding site inhibitors (CBSIs) targeting tubulin have been recognized as attractive agents for cancer therapy, but there are no CBSI drugs currently FDA-approved. CH-2-77 has been reported to have potent anti-proliferative activity against a panel of cancer cells in vitro and efficacious anti-tumor effects on melanoma xenografts, yet, its anti-cancer activity specifically against TNBC is unknown. Herein, we demonstrate that CH-2-77 inhibits the proliferation of both paclitaxel-sensitive and paclitaxel-resistant TNBC cells with an average IC50 of 3 nM. CH-2-77 also efficiently disrupts the microtubule assembly, inhibits the migration and invasion of TNBC cells, and induces G2/M cell cycle arrest. The increased number of apoptotic cells and the pattern of expression of apoptosis-related proteins in treated MDA-MB-231 cells suggests that CH-2-77 induces cell apoptosis through the intrinsic apoptotic pathway. In vivo, CH-2-77 shows acceptable overall pharmacokinetics and strongly suppresses the growth of orthotopic MDA-MB-231 xenografts without gross cumulative toxicities when administered 5 times a week. The in vivo efficacy of CH-2-77 (20 mg/kg) is comparable to that of CA4P (28 mg/kg), a CBSI that went through clinical trials. Importantly, CH-2-77 prevents lung metastasis originating from the mammary fat pad in a dose-dependent manner. Our data demonstrate that CH-2-77 is a promising new generation of tubulin inhibitors that inhibit the growth and metastasis of TNBC, and it is worthy of further development as an anticancer agent.

PMID:35499388 | DOI:10.1158/1535-7163.MCT-21-0899

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Colchicine-binding site agent CH-2-77 as a potent tubulin inhibitor suppressing triple-negative breast cancer - DocWire News

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Rest when youre weary. Refresh and renew yourself, your body, your mind, and your spirit. Then get back to work. This quote from Ralph Marston is a fantastic fit for today's fast-paced world. Every day, we must allow our bodies to rest in order for them to function correctly. And if we don't, we will suffer the consequences. Studies reveal that a good night's sleep has various advantages. It maintains the proper balance of our mind, body, and soul, which is why our skin appears radiant.

The body supports good brain function and physical health while sleeping. Children and teenagers benefit from rest because it promotes growth and development. Not only that, but sleep keeps weariness at bay and boosts productivity says Anish Nagpal, Co-Founder, Dermatouch. Experts reveal that obesity, depression, and lack of attention can all be exacerbated by an insufficient sleep schedule.

Sleep is linked to both emotional and physical well-being, and both influence the appearance of ones skin. According to a study, getting enough sleep helps the brain process emotional information more efficiently, which maintains a person emotionally healthy. Sleep keeps weariness at bay and provides sufficient relaxation for the mind. In the end, mental health issues are also avoided.

"These days, many people suffer from sleep problems, which have a negative impact on their skin. According to dermatologists, it is critical to have a consistent sleep schedule. Sleep helps revitalise our skin at night by improving blood flow and mending damages like wrinkles," explains Nagpal, who adds that getting enough sleep allows our bodies to recover correctly and prepare to perform at their best.

Here Are Some Of The Significant Benefits Of Sleep: During sleep, the growth hormone is secreted, which is necessary for the body's repair and restoration activities. Sleep deprivation leads to weight gain. People who do not get enough sleep feel tired all the time and are unable to even perform their everyday tasks. Sleep deprivation is thought to impair appetite regulation by disrupting daily changes in hunger hormones. Loss of sleep tends to weaken the immune system The stress hormone cortisol rises as a result of little or poor-quality sleep.Here Are Ways To Achieve Better Sleep Quality: Physical activity during the day and proper exposure to sunlight are essential. Before going to bed, dim the lights in your room. Three hours before bedtime, avoid eating anything, which also enhances your overall health. Avoid coffee and alcohol in the late evening and before bedtime. Avoid spicy foods, fried foods, and heavy dinners, as these might cause indigestion and restless sleep. Include foods that promote the production of melatonin, often known as the sleep hormone, in your diet, such as bananas, sweet corn, pineapple, rice, dairy, and barley.

Also Read: Shift Work Does Impact Sleep Quality, Find Out How From The Expert

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Find Out The Benefits Of Getting A Good Night's Sleep | Femina.in - Femina