Rani Therapeutics (NASDAQ:RANI) and Indivior (OTCMKTS:INVVY) Head to Head Survey – Defense World

Rani Therapeutics (NASDAQ:RANI Get Rating) and Indivior (OTCMKTS:INVVY Get Rating) are both medical companies, but which is the superior investment? We will compare the two businesses based on the strength of their dividends, valuation, earnings, institutional ownership, risk, analyst recommendations and profitability.

Analyst Ratings

This is a breakdown of recent ratings and target prices for Rani Therapeutics and Indivior, as reported by MarketBeat.com.

Institutional & Insider Ownership

2.3% of Rani Therapeutics shares are held by institutional investors. 52.3% of Rani Therapeutics shares are held by company insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock will outperform the market over the long term.

Profitability

This table compares Rani Therapeutics and Indiviors net margins, return on equity and return on assets.

Valuation and Earnings

This table compares Rani Therapeutics and Indiviors top-line revenue, earnings per share (EPS) and valuation.

Indivior has higher revenue and earnings than Rani Therapeutics. Rani Therapeutics is trading at a lower price-to-earnings ratio than Indivior, indicating that it is currently the more affordable of the two stocks.

Summary

Indivior beats Rani Therapeutics on 7 of the 13 factors compared between the two stocks.

Rani Therapeutics Company Profile (Get Rating)

Rani Therapeutics Holdings, Inc. operates as a clinical stage biotherapeutics company that develops orally administered biologics. The company develops the RaniPill capsule, a platform that is intended to replace subcutaneous or IV injection of biologics with oral dosing. Its product pipeline includes RT-101, an octreotide, which has completed Phase I clinical trial for the treatment of neuroendocrine tumors and acromegaly; RT-105, an anti-TNF-alpha antibody to treat psoriatic arthritis; RT-102, a parathyroid hormone that is in preclinical studies for the treatment of osteoporosis; RT-109, a human growth hormone to treat growth hormone deficiency; RT-110, a parathyroid hormone for the treatment of hypoparathyroidism; and RT-106, a basal insulin for the treatment of type 2 diabetes. The company was incorporated in 2012 and is headquartered in San Jose, California.

Indivior Company Profile (Get Rating)

Indivior PLC, together with its subsidiaries, engages in the development, manufacture, and sale of buprenorphine-based prescription drugs for the treatment of opioid dependence and co-occurring disorders. The company's product pipeline focuses on treating opioid use disorder, addiction, and schizophrenia. It markets and promotes SUBLOCADE injection for subcutaneous use; and SUBOXONE sublingual film, SUBOXONE sublingual tablet, and SUBUTEX sublingual tablet, as well as sells legacy products that include Temgesic, Burpex, and Buprenex. The company operates in approximately 40 countries worldwide. Indivior PLC has research collaboration agreement with Addex Therapeutics Ltd. The company was incorporated in 2014 and is headquartered in North Chesterfield, Virginia.

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Rani Therapeutics (NASDAQ:RANI) and Indivior (OTCMKTS:INVVY) Head to Head Survey - Defense World

Soleno Therapeutics Announces Presentation of DCCR Data at the 11th International Prader-Willi Syndrome Organisation Conference – BioSpace

REDWOOD CITY, Calif., July 11, 2022 (GLOBE NEWSWIRE) -- Soleno Therapeutics , Inc. (Soleno) (NASDAQ: SLNO), a clinical-stage biopharmaceutical company developing novel therapeutics for the treatment of rare diseases, today announced presentations at the 11th International Prader-Willi Syndrome Organisation (IPWSO) Conference, held on July 6-10, 2022, in Limerick, Ireland.

The presentations by Mr. Pittman and Ms. Bolding included the results from the analysis of caregiver interviews conducted after at least 12 months of investigational, open-label DCCR treatment. The interviews were available for 51 patients who were enrolled in the DCCR Phase 3 program. Casimir Inc (Casimir) completed semi-structured interviews with these participants and interview transcripts were manually coded by trained coders who subsequently analyzed the coded interviews in accordance with a pre-specified statistical analysis plan. Folia Health used the Casimir-prepared transcripts and conducted a semi-automated analysis using Natural Language Processing (NLP) methods.

In the Casimir analysis, 33 (65%), 30 (59%), and 31 (61%) caregivers described a positive change in food-related behavior, non-food-related behavior, and daily life, respectively. Of these, 26 (51%), 20 (39%), and 25 (49%), respectively, reported a positive change with major impact. The analysis was based on thematic coding of 12-month interview data by trained, blinded researchers.

The Folia Health NLP analysis of interview transcripts identified seven problematic behavior domains.88% of participants experienced positive change in at least one behavior with DCCR treatment. Positive change was detected across all seven identified domains, most commonly in food seeking (72%) and daily life (73%).

Both analyses of caregiver interviews presented at IPWSO summarize the positive changes across all seven identified behavioral domains, in both food- and non-food-related behaviors, as well as daily life, while receiving long-term DCCR. These findings, combined with the totality of data generated in our DCCR program, continue to support the potential DCCR has to be a safe and tolerable therapy that may provide meaningful benefit to people with PWS, caregivers, and families, saidAnish Bhatnagar, M.D., Chief Executive Officer ofSoleno Therapeutics.

The presentations by Dr. Miller and Dr. Strong consisted largely of data presented at prior meetings.

About PWSThe Prader-Willi Syndrome Association USAestimates that PWS occurs in one in every 15,000 live births in theU.S.The hallmark symptom of this disorder is hyperphagia, a chronic feeling of insatiable hunger that severely diminishes the quality of life for PWS patients and their families. Additional characteristics of PWS include behavioral problems, cognitive disabilities, low muscle tone, short stature (when not treated with growth hormone), the accumulation of excess body fat, developmental delays, and incomplete sexual development. Hyperphagia can lead to significant morbidities (e.g., obesity, diabetes, cardiovascular disease) and mortality (e.g., stomach rupture, choking, accidental death due to food seeking behavior). In a global survey conducted by theFoundation for Prader-Willi Research, 96.5% of respondents (parent and caregivers) rated hyperphagia and 92.9 % body composition as the most important or a very important symptom to be relieved by a new medicine. There are currently no approved therapies to treat the hyperphagia/appetite, metabolic, cognitive function, or behavioral aspects of the disorder. Diazoxide choline has received Orphan Drug Designation for the treatment of PWS in theU.S.and E.U., and Fast Track Designation in theU.S.

About DCCR (Diazoxide Choline) Extended-Release TabletsDCCR is a novel, proprietary extended-release dosage form containing the crystalline salt of diazoxide and is administered once-daily. The parent molecule, diazoxide, has been used for decades in thousands of patients in a few rare diseases in neonates, infants, children and adults, but has not been approved for use in PWS. Soleno conceived of and established extensive patent protection on the therapeutic use of diazoxide and DCCR in patients with PWS. The DCCR development program is supported by data from five completed Phase 1 clinical studies in healthy volunteers and three completed Phase 2 clinical studies, one of which was in PWS patients. In the PWS Phase 3 study, DCCR showed promise in addressing hyperphagia, the hallmark symptom of PWS, as well as several other symptoms such as aggressive/destructive behaviors, fat mass and other metabolic parameters.

AboutSoleno Therapeutics, Inc.Soleno is focused on the development and commercialization of novel therapeutics for the treatment of rare diseases. The companys lead candidate, DCCR extended-release tablets, a once-daily oral tablet for the treatment of Prader-Willi Syndrome (PWS), is currently being evaluated in a Phase 3 clinical development program. For more information, please visit http://www.soleno.life.

About Folia HealthFolia is a patient-driven Health-IOS (Individual Operating System) that enables individuals to easily take an active role in their care, while contributing to precision diagnostics, patient-centered drug development, & better care for complex diseases. Folias rich longitudinal data and proprietary analytic methods provide a vital and missing piece in the emergence of a home-centered, data-driven healthcare ecosystem. Discover how to harness the power of patient and caregiver knowledge at http://www.foliahealth.com.

About CasimirCasimir is a Contract Research Organization (CRO) that develops novel outcomes for decentralized and hybrid trials in order to better understand disease progression and treatment benefit.Casimir was recently acquired by Emmes, a global full-service CRO dedicated to excellence in supporting the advancement of public health and biopharmaceutical innovation. To learn more about how our research is making a positive impact on human health, visitwww.emmes.com.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended. All statements other than statements of historical facts contained in this press release are forward-looking statements, including statements regarding timing of any regulatory process or ultimate approvals and determining a path forward for DCCR for the treatment of PWS. In some cases, you can identify forward-looking statements by terms such as "may," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplates," "believes," "estimates," "predicts," "potential" or "continue" or the negative of these terms or other similar expressions. These forward-looking statements speak only as of the date of this press release and are subject to a number of risks, uncertainties and assumptions, including the risks and uncertainties associated with market conditions, as well as risks and uncertainties inherent in Solenos business, including those described in the company's prior press releases and in the periodic reports it files with theSEC. The events and circumstances reflected in the company's forward-looking statements may not be achieved or occur and actual results could differ materially from those projected in the forward-looking statements. Except as required by applicable law, the company does not plan to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise.

Corporate Contact:Brian RitchieLifeSci Advisors, LLC212-915-2578

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Soleno Therapeutics Announces Presentation of DCCR Data at the 11th International Prader-Willi Syndrome Organisation Conference - BioSpace

12 Benefits of Kettlebell Swings That Will Have You Swinging in No Time – BarBend

You love nothing more than getting to the gym as often as you can. But alas life happens. When you havent got a lot of time for training nor room in your apartment for outfitting an entire home gym all you need to keep going is a kettlebell.

Moves like the kettlebell swing dont require a lot of space. You also dont need to train for hours on end to see results. Only got six minutes? Cool. Swing a kettlebell in that gap between meetings, and your strength and overall fitness levels will start to rise.

Mastering the kettlebell swing can solve a whole world of lifting problems. Maybe you didnt notice that your hip hinge form was off until you loaded that fourth plate onto the barbell. Kettlebell swings give you instant feedback to help you teach and reinforce proper hip hinge mechanics. They also get your heart pumping enough to improve your cardio fitness on par with running and other traditional exercises. Read on to find out what else kettlebell swings can do for you and your gains.

Editors note: The content on BarBend is meant to be informative in nature, but it shouldnt take the place of advice and/or supervision from a medical professional. The opinions and articles on this site are not intended for use as diagnosis, prevention, and/or treatment of health problems. Speak with your physician if you have any concerns.

Strength athletes who want to incorporate explosive power into their training might want to do so with minimal impact on their joints. To bolster recovery while also increasing your rate of force development and rapid muscle activation, opt for low-impact kettlebell swings. This dynamic hip hinge boosts your power and explosiveness at a level thats on par with plyometric moves like the jump squat. (1)

Even lifters at intermediate and advanced training levels can boost the challenges to their power and strength training with kettlebell swings. Periodized kettlebell swing training where you increase the weight youre lifting gradually over the course of several weeks can dramatically improve an athletes power production and strength. (2)

Kettlebell swings dont just help boost your power they can also help make you stronger. (1)(2) Just six weeks of training with heavy kettlebells can improve your half squat max. (1) Thats especially significant if youre trying to iron out any kinks in your squat training that require you to get stronger in the back half of the lift. Incorporating kettlebell swings into your program can even help boost your full squat one-rep max. (2)

Thats to say nothing of your core and grip strength, which get a huge increase from kettlebell swings. Your core keeps you stable while your grip keeps the bell in your hands. And because swings are continuous, neither will get a break until youre done.

You dont have to swing heavy or for very long to get your cardio in when you have a kettlebell. Grab a 16-kilogram kettlebell and perform as many reps as possible in 12 minutes. Research suggests that this type of protocol can significantly increase your oxygen consumption and positively impact your cardio health. (3) This makes kettlebells a viable form of cardio for folks who want to improve their cardiovascular health without running and without spending hours doing steady-state work. (3)

Weight training by day and dunking basketballs by night? Kettlebell swings can help your LeBron-oriented cause. Swinging heavy bells for only six weeks can improve your vertical jump height just as much as jump squat training. (1)(2)

Physically jumping with exercises like box jumps and broad jumps arent always accessible for athletes. You might not have access to a plyo box or may live above neighbors who wont appreciate the banging around on their ceiling. You also might have limitations from joint pain. Swing some bells instead and youll be looking at similar gains when youre able to jump again.

Even if you like running and box jumps, theres no denying that they can take a pretty hefty toll on your joints. If youve got achy knees or plantar fasciitis, even the most rigorous of warm-ups might still leave you hobbling after a running bout or box jump session. Enter kettlebell swings you can boost your power and cardio health without all that banging around.

Because your feet stay in the same position and your knees dont move much, kettlebell swings can be ideal for people with various aches and pains in their knees or feet. (4) Swings can even help get your muscles used to the kinds of pressure that strength training can place on your low back and hips. (5) This may set you up for more success during more intense lifts or higher-impact activities.

Short on time? Kettlebell swings might just be your new go-to for gains. Just four minutes of swings with a Tabata protocol 20 seconds on, 10 seconds of rest can significantly boost your aerobic capacity. (6)

Swinging for 10 minutes total with work:rest intervals of 35 seconds to 25 seconds is also sufficient for improving your cardio health. (7) Six minutes of kettlebell swings can also boost your muscular endurance, which is a win for your overall strength training. (8)

Not a lot of space to work out in your studio apartment? Square footage isnt an issue when youre training with kettlebells. All you need is a few feet of space in front of your couch will do quite nicely for an intense kettlebell swinging session. Kettlebells also dont take a lot of room to store. Slip one into the corner of your room and break it out any time you need to break a sweat.

Properly performing kettlebell swings involves squeezing your glutes at the top of each repetition. Youre essentially performing high-volume hip hinges, driving and finishing each rep with your glutes. Research shows that the weight of the bell provides instantaneous feedback as to whether youre sufficiently activating your glutes during swings. (9)

The more efficiently you can activate your glutes, the more successful your big pulls think, deadlifts are likely to be. Nailing your hip hinge mechanics during kettlebell swings means youre putting your body under less loaded stress than with high volume deadlifts. But youll still be stimulating glute growth and practicing proper hinging technique. (9)

Performing kettlebell swings just twice a week for six weeks can significantly improve your muscular endurance. (8) To get this effect with just two sessions per week, try performing 12 sets of 30-second rounds of kettlebell swings with 30-second rest periods. (8) Youll also want to progress the weight youre using by four kilograms every two weeks as opposed to keeping the weight the same to ensure maximum results. (8)

Kettlebell swings dont just leave you winded. They also produce an acute hormonal response in your body. Just six minutes of kettlebell swings with a 30-seconds on, 30-seconds off protocol can significantly increase your growth hormone and testosterone levels. (10) Cortisol and lactate levels also rise, along with your heart rate, during these brief bouts. (10) These hormones are often associated with muscle adaptations so it seems that you dont have to have long sessions for big results.

Whether youre pulling a heavy barbell from the ground or youre unracking a heavy load on your back, you need great spinal stability as a strength athlete. Swinging a bell three times a week for eight weeks can increase your ability to resist sudden, loaded pressure on your spine. (11)

This may be particularly useful for contact sports athletes who need to brace against tackles or other impacts. Spinal stability also comes in handy during barbell lifts, including when you snatch a loaded barbell very quickly overhead.

The direction of the force on your body during a properly-performed kettlebell swing is largely horizontal, as opposed to vertical. (12) As a result, there may be less shearing force on your spine during kettlebell swings than during loaded barbell lifts, potentially reducing the risk of a low back injury.

With that said, movements like the kettlebell swing have been shown to increase lumbar shear and compression during swinging movements when not performed properly. (13) So make sure youre doing your swings correctly. Keep the bell above your knees, your back neutral, and your lats engaged with a strong hip snap.

Doing kettlebell swings the right way is essential. Heres how to get them done efficiently and effectively.

Keep your chin in a neutral position throughout the lift. Exhale as you explode up to increase your coordination and core engagement.

Its not all about the double-handed swing although that is a tremendously valuable tool to have in your box. These kettlebell swing variations will get your heart thumping and your power skyrocketing, too.

Traditional kettlebell swings are performed with two hands. When you opt for using just one hand, youll be engaging your core even more than normal. Youll need to resist rotation throughout the swing, which requires your core to fire up in a big way.

You can perform this move continuously with one arm at a time. Or, you can alternate your swings, switching hands each time the bell approaches your chest level.

Normally, kettlebell swings are a very continuous, fluid movement. When you add a dead stop, youll be doing pretty much what it says on the tin. Youll be coming to a dead stop on the ground between each rep.

Doing this kills the momentum from rep to rep. Without momentum, youll need to rebrace your body between swings. Youll be generating the force of your initial hike backward from scratch each time. In doing so, youre maximizing your muscle recruitment and therefore, your potential strength gains.

Any time youre staggering your stance, youre putting your body off-balance. Normally with kettlebell swings, your feet will be aligned as normal underneath you. But with a staggered stance, youll be increasing your core engagement and ironing out any strength imbalances you might have between your legs.

It might take you some trial and error to find the optimal staggered stance for you. You want your feet close enough together to maintain perfect, forward-facing form. However, you want them far enough apart to make a difference from your regular stance. Start small and light, and progress from there.

When its time to integrate kettlebell swings into your program, youll want to consider exactly what your goals are. Are you trying to increase your cardio fitness? Practice your hip hinge mechanics? All of this makes a difference in terms of how youre programming your sets, reps, and timing.

After the movement prep components of your dynamic warm-up, kettlebell swings can serve as a great way to get your blood pumping, elevate your heart rate, and prepare your muscles for bigger movements. Perform three sets of 10 to 15 reps with a light to moderate weight toward the end of your warm-up.

Like plyometrics, you can do explosive and maximal force kettlebell swings after strength movements like squats. According to the principles of post-activation potentiation where you follow a heavy strength move with an explosive exercise to maximize your gains this can increase both your strength and power.

Focus here on explosive, low-rep sets. Try following a heavy squat or deadlift set with a set of three to five kettlebell swings.

Using kettlebells to improve your cardio fitness and conditioning is an attractive option for folks who cant stand treadmills. You can program this type of training in any number of ways. You can do kettlebell swings with the Tabata protocol, where youll spend four minutes swinging for 20 seconds and resting for 10 seconds. If youre more experienced, you can take a page out of kettlebell sports book and opt to find out how many crisp swings you can do in 10 minutes.

The possibilities for kettlebell cardio training are nearly endless. You can do a kettlebell swing EMOM (every minute, on the minute), aiming to perform 10 or 20 swings a minute for 10 minutes. Do this or protocols like it as a workout finisher, as its own cardio training session, or even during an active recovery day.

If youve got a kettlebell, youve got the key to improving pretty much any aspect of your strength training. Learning how to swing a kettlebell opens up an entire world of possibilities for your overall cardio fitness and strength. Even if youre a barbell nerd, kettlebell swings will help promote the spinal stability and explosive strength you need to bust through plateaus. Become your best self on the platform by swinging a kettlebell wherever your training finds you.

Featured Image: Srdjan Randjelovic / Shutterstock

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12 Benefits of Kettlebell Swings That Will Have You Swinging in No Time - BarBend

Electro-Optical/Infrared (Eo/Ir) Systems Market to Witness Huge Growth by 2029 -Lockheed Martin Corporation, General Dynamics, L-3Harris Technologies,…

TheElectro-Optical/Infrared (Eo/Ir) Systemsmarket is globally one of the leading markets involving innovative techniques development and extremely categorized sector. After a thorough investigation conducted over the industries under Electro-Optical/Infrared (Eo/Ir) Systems market, the market report delivers in-depth information, based on the data related to export and import along with the ongoing industry trends in the global market. The report deeply observes the competitive structure of the Electro-Optical/Infrared (Eo/Ir) Systems market worldwide. The Electro-Optical/Infrared (Eo/Ir) Systems market report comprises the detailed summary of the various firms, manufacturers, organizations, and other competitive players that hold major count over the global market in terms of demand, sales, and revenue by providing reliable products and services to the customers worldwide.

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The global Electro-Optical/Infrared (Eo/Ir) Systems market report renders notable information about the Electro-Optical/Infrared (Eo/Ir) Systems market by fragmenting the market into various segments. The global Electro-Optical/Infrared (Eo/Ir) Systems market report delivers a comprehensive overview of the markets global development including its features and forecast. It requires deep research studies and analytical power to understand the technology, ideas, methodologies, and theories involved in understanding the market.

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Electro-Optical/Infrared (Eo/Ir) Systems Market to Witness Huge Growth by 2029 -Lockheed Martin Corporation, General Dynamics, L-3Harris Technologies,...

Increase in Leptin Levels in Preeclampsia Prompts Cardiovascular Cascade That Puts Mother and Baby at Risk – Diagnostic and Interventional Cardiology

June 30, 2022 Before a baby is ever born, critical supply chain problems with nutrition and oxygen can result in premature birth or even death and increase the child and mothers lifelong risk of cardiovascular disease.

Scientists have found that a midgestation increase in the hormone leptin, which most of us associate with appetite suppression, produces problematic blood vessel dysfunction and restriction of the babys growth inpreeclampsiathat put mother and baby at risk.

Its known that about 20 weeks into a pregnancy, women with preeclampsia experience an increase in the production of leptin by the placenta but the consequences have been unknown.

Its kind of emerging as a marker of preeclampsia, saysDr. Jessica Faulkner, vascular physiologist in theDepartment of Physiologyat theMedical College of Georgiaand corresponding author of thestudyin the journalHypertension.

Leptin, mostly produced by fat cells, is also produced by the temporary organ, the placenta, which enables the mom to supply her developing baby with nutrients and oxygen, Faulkner says. Leptin levels steadily increase in a healthy pregnancy, but specifically what leptin is doing even normally in this scenario is unclear. There is some evidence its a natural nutrient sensor in reproduction or maybe a way to enable new blood vessel growth and/or to stimulate growth hormone for usual development.

But in preeclamptic patients leptin levels go up more than they should, Faulkner says.

The new research looking at the impact shows for the first time that the increase in leptin results in endothelial dysfunction in which blood vessels constrict, their ability to relax is impaired and the babys growth is restricted.

When the scientists inhibited the precursor for the powerful, natural blood vessel dilator nitric oxide, like what happens in hypertension, it pretty much replicates the effect of the midgestation leptin increase.

To make matters worse, the scientists also have evidence that leptin plays a role in increasing levels of the blood vessel constrictor endothelin 1.

Conversely when they deleted the receptor for aldosterone, in this case the mineralocorticoid receptors on the surface of the cells that line blood vessels, endothelial dysfunction didnt happen, saysDr. Eric Belin de Chantemele, physiologist in MCGsVascular Biology Centerand the papers senior author.

We think what is going on in preeclamptic patients is the placenta is not properly formed, Faulkner says. In the middle of gestation, fetal growth is not happening as it should. I think the placenta is compensating by increasing leptin production, potentially with the goal of helping spur more normal growth. But the results appear to be just the opposite.

It can hurt the babys development and increase the risk of long-term health problems for the baby and mother, she says.

While leptin has been associated with preeclampsia, this was the first study to show that when leptin goes up, it induces the unhealthy clinical characteristics of preeclampsia, Belin de Chantemele says.

When they infused leptin in pregnant mice to mimic the surge that happens in preeclampsia, they saw an unhealthy chain reaction with the adrenal gland making more of the steroid hormone aldosterone which could be increasing the production of endothelin 1, also by the placenta.

Their previous work has shown that outside of pregnancy, an infusion of leptin results in endothelial dysfunction. Belin de Chantemeles lab has pioneered work showing that fat-derived leptin directly prompts the adrenal glands to make more aldosterone which activates mineralocorticoid receptors found throughout the body, notably in the blood vessels in females, which is important to blood pressure levels. High aldosterone levels are an obesity hallmark and a leading cause of metabolic and cardiovascular problems.

That work made them hypothesize that the infusion of leptin that occurs midgestation in preeclampsia had a similar impact that deletion of the mineralocorticoid receptors lining blood vessels could resolve. They have connected similar physiological dots in young females in whom obesity often robs the early years of protection from cardiovascular disease that being female typically provides until menopause.

These same players likely are factors in what increases the mothers lifetime risk of cardiovascular problems, Faulkner says.

It means the system is dysregulated and that is basically when you develop disease, she says.

Their goals include better defining the pathways for increased blood pressure and other blood vessel dysfunction, pathways that can be targeted during pregnancy to prevent potentially devastating results for mother and baby, from what Faulkner characterizes as a two-hit condition.

Their findings to date indicate that effective therapies to better protect mother and baby could be existing drugs like eplerenone, a blood pressure medicine that binds to the mineralocorticoid receptor effectively reducing the effect of higher levels of aldosterone, the scientists say.

The problems likely start with the placenta, and potentially inadequate blood flow to the temporary organ early in its development and subsequent failure of the development of the big blood vessels that become the passageway for nutrients and oxygen from mother to baby.

Its known that in preeclampsia there are problems like decreased secretion of placental growth factor. The bottom lines appear to be that by midgestation, the placenta can no longer properly support the baby, which may be why it secretes leptin, possibly in an effort to spur its own growth and normal fetal development, but in reality it contributes to cardiovascular and fetal consequences, the scientists report, including raising the mothers blood pressure.

Preeclampsia rates unfortunately are rising, Faulkner says, both in the number of pregnant women affected and in how severely they are affected. According to an analysis of data from the Centers for Disease Control and Preventionpublishedin January of this year in theJournal of the American Heart Association, rates of hypertension that arise during pregnancy, including preeclampsia and gestational hypertension, have nearly doubled in both rural and urban areas in this country from 2007-19 and have been accelerating since 2014. Gestational hypertension is an increase in a pregnant womans blood midgestation but without associated signs of protein in the urine, a sign of kidney distress, or markers of placental dysfunction, as are found in preeclampsia.

Risk factorsinclude carrying more than one fetus, chronic high blood pressure, type 1 or 2 diabetes, kidney disease, autoimmune disorders before pregnancy as well as use of in vitro fertilization. Increasing rates of preeclampsia are primarily attributed to obesity, which is a risk factor for many of these conditions and associated with high levels of both aldosterone and leptin, Faulkner says. Other times, women seem to develop the problem spontaneously.

Next steps in the research include better understanding how and why leptin goes up more than it should, Faulkner says.

For more information:www.augusta.edu

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In need of a good night’s sleep? Here’s tips and help from a doctor| Betty Lin-Fisher – Akron Beacon Journal

Todays column may make you sleepy and that could be a good thing!

For this months Healthy Actions column, our expert is Dr. Eileen Wong, University Hospitals East Region Sleep Lab Medical Director. She is based at sleep labs in Streetsboro and in Geauga County.

The Healthy Actions column is a monthly look at a different medical topic of interest with a local medical expert. To read previous columns, go to http://www.tinyurl.com/BettyHealthyActions

More: Betty Lin-Fisher: Links to Healthy Actions columns

Wong and her colleagues see patients who are having problems with sleep, whether its problems falling asleep, staying asleep, snoringor if the person stops breathing during sleep. They also see patients who move their legs excessively at nightor patients who are excessively sleepy during the daytime.

The following is an edited version of an interview with Wong. There is also anNow You Know Akron podcast of our interview available.

It really depends on your age. If you are 18 and above, seven to nine hours is actually good and when you reach age 65, seven to eight hours is recommended.

However, if you sleep six hours, it's still acceptable. If it's less than six hours, that's probably too little.

There is also a segment of the population whom we call short sleepers. They usually sleep less than six hours and then they feel good. They don't have issues like fatigue in the daytime, problems with memory, mood, concentration or drowsy driving or daytime sleepiness.

For the most part, people usually need seven to nine hours and research has shown that seven is actually better.

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There are two stages of sleep: non-REM or non rapid eye movement sleep and sleep when you are dreaming, which is called REM sleep, or rapid eye movement.

Non-REM is usually good for physical health. REM sleep is good for your mental health. During REM sleep, that's the time where our brain is trying to recall what we learned in the morning and in the daytime and then to relearn how to do it.

There are three stages of non-REM sleep before REM. The deep sleep that were talking about or restorative sleep is not really in REM, but Stage 3 of non-REM sleep.

In kids, the deep sleep is very important because thats the time the growth hormone is produced so they can grow taller and all those things.Our immunity is also enhanced during deep sleep.

Yes, so with a normal patient, you start with non-REM stages 1, 2 and 3 and then you go into REM. And then sometimes from REM, you go to Stage 2 and then go back to 3 and then 1. It really depends on the person. So it's like an alternating cycle. Each cycle can last anywhere from 90 to 100 minutes. Each cycle is composed of non-REM and REM.

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A good, restful sleep has a lot of benefits for us. Its the time where our memories are consolidated and stored. Its the time where muscles repair and recover.

If you dont sleep well, the following day, you feel like your judgment and concentration areimpaired. Your reaction time is slowed. There's a lot of short-term and long-term issues when youre not getting adequate sleep.

The TV, laptop, cell phone andiPadactually emit blue light. When your brain sees this blue light, it thinks we need to be awake.

We usually tell patients that part of a good sleep habit is to turn off any gadgets that emit blue light anywhere from one to two hours before you go to sleep. We tell patients dont go to sleep unless youre sleepy. If you are in bed and youre not falling asleep in 15 minutes, get out of bed. Go to a chair inside your bedroom or another room and do something boring.

When you get up and grab your phone, youre exposing yourself to the blue light again and its going to be hard to fall back asleep or fall asleep. Do something boring and make sure it's under dim light like yellow light. If you turn on your white light in the room or you start exposing yourself to gadgets that emit blue light, then you start telling your brain thatyou need to be more awake.

Some of my patients flip through magazines or color until they feel sleepy.

You should avoid napping during the daytime. When you're awake during the daytime, you're building up sleep pressure and when the sleep pressure peaks, that's the time you feel sleepy. If you sleep in the daytime, then your sleep pressure goes down and it will be harder for you to fall asleep at night.

Caffeine usually blocks the adenosine in the body and this adenosine is the one that contributes to the sleep pressure.

Different patients have different rates of metabolism. As an example, when I was younger when I drank caffeine at 6 p.m., I could still fall asleep at 9 p.m. But for some reason as I got older, I have to cut my caffeine by noon otherwise I cant fall asleep at night.

As we get older, it seems the metabolism of caffeine is slower. We usually advise patients to cut it off past noon.

I tell patients to limit fluid intake to 8 ounces at dinnertime and after that, do not drink any more water. If you have pills to take at bedtime, make sure to drink it with only sips of water or just enough to swallow the pills. That way, when you go to sleep, you dont wake up a lot to go to the bathroom.

Patients who have some type of abnormal behavior in their sleep would come to see me. Or sometimes its not an abnormal behavior, but breathing problems. The most common patient we see in the sleep clinic is someone with breathing problems during sleep. That can be because the husband is snoring so loud and sounds like a dragon and the wife cannot sleep, so the wifes sleep is affected.

Some patients stop breathing while sleeping or wake up gasping for air or have a choking sensation during sleep. We also have patients who are drowsy driving in the morning, or people who excessively sleep during the daytime.

Some other patients have abnormal sensations in the legs before sleeping. That's usually related to Restless Leg Syndrome or some patients act out their dreams during sleep. Some may have sleepwalking behaviors or some people call them sleep terrors. Those are also things to be seen by a sleep specialist.

Other reasons patients might see a sleep specialist would be problems falling asleep or staying asleep, or fatigue, increased irritability, general malaise or even cognitive impairment, usually in adults.

Adults and kids also show different symptoms. Kids who dont have a restful sleep may show it it in poor school performance, impaired attention or sometimes aggression or hyperactivity.

Still other issues to see a sleep specialist might be narcolepsy, which is not common, but patients can fall asleep while standing or during an activity, like eating. As soon as they fall asleep, they go into the dreaming stage.

Some patients also may have a sleep-eating behavior where they wake up and look for something to eat and dont remember the following day.

Some patients also have circadian rhythm problems, which are body clock issues being awake at night and sleepy during the day.

It depends on the insurance. Some need a referral and some allow a self-referral.

There are two types of sleep studies: a home sleep apnea test and an in-lab sleep study. Sometimes it depends on what insurance will cover. Some insurances only cover an in-home study before they cover an in-lab study. Most commonly, we do sleep studies for sleep apnea and narcolepsy.

An in-lab sleep study will gather a lot more data since there are air-flow sensors, belts watching breathing and monitors on the finger to check for heart rate and oxygen saturation. We also watch heart rhythms and check for leg movement. There are also wires on the scalp to check for sleep staging.

If a patient comes back positive in an in-home sleep study for sleep apnea, there are two options: We either start a patient right away with a CPAP machine (which stands for continuous positive airway pressure) or we can have them come in for an in-labstudy.

If a CPAP machine is not tolerated, we may try a BIPAP (bi-level positive airway pressure) machine or add oxygen. Some patients may need an ASV (adaptive servo-ventilation) machine.

We also sometimes use an oral appliance, worn on the upper and lower jaw during sleep, though it depends on insurance.

Another option is something we call Inspire, which is fairly new. It is basically a battery implanted under your skin that comes with a remote control. At night, the device moves the tongue forward every time the patient is breathing while sleeping. It kind of looks like a pacemaker.

For sleep apnea, theres still research being done to see if there are medications to help. Right now, there are no medications that are highly effective for sleep apnea.

Our body produces melatonin, which calms our body and brain to prepare the body for sleep. Some patients find melatonin supplements effective and some dont. It is not a sleeping pill, but helps the body to prepare to fall asleep.

Sometimes we use melatonin to move the body clock forward if you stay up past midnight, but you have to wake up at 6 a.m. for school, but youre sleepy during the daytime.

Bottom line, if it is for body-clock issues, melatonin is a good medication that we use.

We usually dont want patients taking over-the-counter sleeping pills that have things like Benedryl or diphenhydramine because it can cause you to have restless leg syndrome. We also want patients to sleep naturally and not rely on medications to fall asleep.

Beacon Journal staff reporter Betty Lin-Fisher can be reached at 330-996-3724 or blinfisher@thebeaconjournal.com. Follow her @blinfisherABJ on Twitter or http://www.facebook.com/BettyLinFisherABJ To see her most recent stories and columns, go to http://www.tinyurl.com/bettylinfisher

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In need of a good night's sleep? Here's tips and help from a doctor| Betty Lin-Fisher - Akron Beacon Journal

‘I did the Daisy Keech ab workout every day for a week, here’s everything I learned’ – Women’s Health UK

The Daisy Keech ab workout has had over 23 million views on YouTube since it went live last year. Keech claims that by doing the ab workout every day, you could carve yourself the perfect hourglass waist, but Im sceptical. Exercise alone is highly unlikely to change your body shape various other factors are at play, like genetics and nutrition (check out our complete guide on how to get a smaller waist) so to promise a cinched waist through a single workout seems deductive. Plus, theres so much more to be gained from performance goals over aesthetic ones the sense of accomplishment and confidence that comes with lifting heavier when strength training, for example.

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Granted, the Daisy Keech ab workout may well contribute to more muscle definition, if thats what youre after, and if you enjoy the routine, then were not saying you should give it up. Its more that we wouldnt recommend following a workout routine purely for aesthetic reasons.

Whats more, weve been unable to confirm whether or not Keech is a certified personal trainer, which is why we called upon two fitness experts for their verdicts: Anthony Fletcher, a PT and biomechanics expert, and Sarah Winterbottom, Senior Trainer at Barry's Bootcamp, and a trainer on Courtney Blacks app. Heres everything they have to say about the Daisy Keech ab workout, after I tried it every day for a week.

Heres exactly whats involved in the Daisy Keech hourglass abs workout. Every exercise is done back to back, no rest for 10 minutes.

The chances of it garnering an hourglass waist like it claims are slim. Fletcher explains: 'The shape of your waist is mainly determined by the amount of tissue you have in the area, the shape of your rib cage, your pelvis, and the gap between your pelvis and the ribs. How small or big your waist looks will also depend on how broad your shoulders are.

'We can't affect any of these by exercise alone, and doing just 10 minutes a day won't influence the amount of tissue you have. Most of these factors are down to genetics.'

That said, Fletcher adds that while maintaining a core routine probably won't do much for said "hourglass" figure, it could be useful in other ways. 'There is lots of evidence that suggests keeping your muscles around the spine (i.e. your core) active could protect your spine from harm. However, the Daisy Keech hourglass routine is solely focussed on the front of your abdominals and hip flexors, which may create an imbalance in the stability of your spine, if this is the only form of training you do.

'The upshot is that you may have greater endurance in the anterior muscles of your trunk, neck and hips, but it won't provide an "hourglass" shape.'

Winterbottom adds: 'The hourglass workout is focussed on the upper and lower abs. It can be useful to isolate these specific muscle groups, but improving overall core strength should be the goal, and to do this you need to include all three planes of motion (up, down, side to side, and forwards and backwards). The exercises in Daisy Keech's ab workout cover only the up and down movement.'

Besides an intro and outro, Daisy doesnt speak during any of the exercises. No form cues, no technique advice. Nada. She does let you know when its time to move onto the next exercise, but all she gives is the name of the move. Theres so much to think about when doing ab exercises if you want to do them properly and without injury, and, IMO, its the coachs job to take you through them. Instead, I found myself craning my neck to try and get a closer look at her technique for me to imitate. Not the one.

During her intro, Keech mentions that she doesnt do oblique exercises because she doesnt want to build her waist out, rather cinch it in. From all the fitness experts I've interviewed and research I've done in my time, this was a big red flag. I've always been told that a balanced body is the one that will serve you best, so to disregard a certain area of your core purely for aesthetic reasons seemed wild.

Granted, a week wasnt long enough for me to notice any issues, but Id hedge my bets that if I never did oblique exercises, Id struggle with other workouts, like yoga and reformer Pilates, which require full body strength.

Fletcher tells me this would almost certainly be the case, adding that neglecting oblique work could increase the risk of injury. 'Training your obliques is usually done in a lateral direction. If you don't practice exercises in this plane of motion you could reduce your stability and therefore increase your risk of injury.

'Your obliques also play a major role in protecting your spine. Every muscle in your trunk, including your obliques, protect your spine by distributing forces through their connective tissue, which reduces stress on the discs of your spine. If you don't strengthen them, you'll run the risk of injuring your back.'

Winterbottom wagers that ignoring the oblique area could be particularly problematic in our day and age, when most of us spend a lot of time working from home, which can lead to a 'more sedentary lifestyle'. 'Having strong obliques can help reduce lower back pain, which I'm seeing a lot more of nowadays, when a lot of my clients spend more time than ever sitting at a desk,' she explains, adding that oblique exercises are also key for good posture and balance.

I dont know about you, but doing the same exercises day in, day out, quickly got tedious. Theres certainly something to be said for practicing the same moves repeatedly (its the only way youll get better at them, after all), but there are plenty of other ab exercises that could work the same area.

Fletcher recommends adding in the following moves to your core routine: 'A simple side plank to increase the capacity of the muscles at either side of your spine would be a good option to add in, as well as a bird dog to train your endurance and neural connections between the lower back muscles, hips and upper back. And a kneeling shoulder tap to train your muscles to resist rotation and keep your spine in a potentially safer position than your usual seated twists.'

And Winterbottom? 'The most effective core exercises are functional ones that'll help you move more effectively and efficiently in day-to-day life, and I always make sure my clients' workouts cover all planes of movement. My favourite core exercises for this are hollow holds, planks, oblique crunches, jackknives and deadlifts.'

Not only does Keech not allow rest between exercise sets, youre not permitted any days off. This could hinder muscle growth. Several studies have shown that neglecting rest days and overtraining can cause an increase in cortisol (the main stress hormone in the body), which can lead to a reduction of growth hormone (GH) release, which is related to reduced muscle mass and strength.

Fletcher explains how a lack of rest during sets of exercises could also be detrimental. 'The more burn you feel, the weaker you're likely to feel, and if this weakness compromises technique then you'll run the risk of injury, and won't reap the rewards of the workout.'

He cites one particular study in which one group of rugby players who were pushed to use a weight to failure were compared to another, who did a few reps, followed by a small rest, then repeated another set of reps. The study showed that the group who took rest breaks was just as strong as the group who didn't. Go figure.

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Winterbottom concurs: 'It's especially important to maintain form when training your core, as if your muscles fatigue and you let your technique slip, your lower back can start to overcompensate, which is where injury may come in.'

And not taking any rest days? 'Muscle soreness is produced from muscle damage and the damage must repair before your muscles can function optimally again,' Fletcher says. 'If you don't feel sore the next day, then there was potentially little damage created, and you might be good to go again. But damage and recovery are important factors in getting stronger. I don't advocate people pushing their muscles hard everyday, as this could potentially disrupt the recovery process and could lead to injury.'

We're not about the whole 'transformation' rhetoric (they're often associated with quick fixes, and sustainable, lifestyle habits should always come first), but I wanted to share my 'before and after' results, to prove that following the Daisy Keech ab workout every day for a week may not do much at all for your body shape, if that's what you're looking for.

I can, however, vouch for the workout working your ab muscles, in that mine definitely ached each day. So, if you take our advice and punt for performance and skill-based goals over aesthetic ones, the Daisy Keech ab workout may well come in useful - just keep in mind our points on form, taking rest if needed and incorporating exercises that target every muscle in your core.

If you, or anyone you know, is struggling with an eating disorder, contact Beat, the UK-based charity who hope to end the pain and suffering caused by eating disorders.T: 0808 801 0677E: help@beateatingdisorders.org.uk, under-18s: fyp@beateatingdisorders.org.uk

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'I did the Daisy Keech ab workout every day for a week, here's everything I learned' - Women's Health UK

STRESSING OUT: Drought and trees, explained | Local News | weatherforddemocrat.com – Weatherford Democrat

COLLEGE STATION Only mid-way through June and Texas has already seen extreme heat and very little rain this summer, with the trend predicted to continue. The anticipation of drought can bring many thoughts to mind from water shortages to increased wildfire risk, but what do drought conditions mean for our trees?

Drought is defined by a relatively long duration with substantially below-normal precipitation, usually occurring over a large area, and Texas is no stranger to drought. According to the US Drought Monitor, in 2011 more than 80% of Texas experienced exceptional drought conditions. This drought killed an estimated 300 million trees, 5.6 million being urban shade trees.

According to experts at Texas A&M Forest Service, tree fatalities occur during a drought because drought is a significant stress to trees.

A stress is anything that reduces the capacity of the tree to function efficiently and grow vigorously, said Karl Flocke, Texas A&M Forest Service woodland ecologist. Stresses are things that can affect growth, nutrient uptake, the ability of the tree to photosynthesize and ultimately the ability of the tree to defend itself against pathogens things like heat, cold, predation from animals, insects and diseases a number of different things.

Drought alone may not kill your trees, though it could be the tipping domino of tree mortality and should be cause for concern.

Most trees usually die from a combination of different stresses, said Courtney Blevins, Texas A&M Forest Service urban forester. One of the biggest stresses we see in Texas is drought. When that happens, stresses build up and secondary pests or diseases can establish in trees.

Secondary pests and diseases are those that attack a tree that is already stressed by something else, such as a drought or a winter storm. Hypoxylon and most boring insects are considered secondary pests and diseases with the exception of the Emerald Ash Borer, which attacks both healthy and stressed ash trees.

When a tree is already stressed, then these types of insects and diseases will increase and according to Blevins, these secondary insects and diseases not only increase during the time of drought, but for years after a drought or other large stressor event has ended as it takes time for trees to recover.

Drought-stressed trees

So, what happens to trees during a drought? Ultimately, the lack of water causes trees to photosynthesize less, or make less food, which leads to a lack of nutrients needed to survive.

Plants generate their own food through photosynthesis and one of the key components of photosynthesis is water, said Flocke. Water is necessary for the chemical reactions that create sugars, its also necessary to help move the needed materials around in the tree and finally, to utilize those materials.

Without water, a tree cannot generate sugars and cannot utilize those sugars a necessary part for the entire process of tree growth. When this happens, trees will start to show physical symptoms of the lack of nutrients. While these symptoms can vary from species to species, most trees will begin to show signs of water stress through their leaves.

The things to look for on your tree are leaves dropping or wilting, small or malformed leaves, yellowing of the leaves and browning tips of the leaves, said Blevins. Some species, like junipers, may totally brown out, losing all of their leaves.

Just because leaves begin to fall from your tree, does not mean the tree is dead though. For small trees, you can simply use your thumb nail and scrape some of the smaller twigs - if there is still green underneath, then the tree is not dead. Within a few weeks, it may leaf back out. If you are concerned your tree is dead, contact a certified arborist for a professional opinion.

Reducing tree stress

The most helpful way to reduce stress to your tree during drought conditions is to give supplemental water though the amount and how often you water will depend on your specific tree and area.

Watering is going to depend on the tree; the size, species and age of the tree as well as the soils you have in your area, said Flocke. If you have established trees that are well-adapted to your location, its very likely that they might not need supplemental water at all. But I would monitor them to look for signs of stress.

If you begin to see signs of stress in your trees and the ground under your trees is extremely dry, its time to begin watering. To test the dryness of the soil, you can take a long screwdriver and stick it in the ground. If the screwdriver doesnt go easily six to eight inches into the soil, its time to water.

Start by watering the area around the canopy of the tree, said Flocke. Not just at the base of the tree and not just around the edge of the dripline but water the entire area underneath the canopy of the tree until the point where you have water start pooling and running off the surface.

Watering can be done with a water hose, soaker hose, sprinkler or bucket each way being efficient so long as the tree is getting the water it needs. A good guideline for the amount of water your tree needs is two to three gallons per one inch trunk diameter.

According to Blevins, a general rule of thumb for newly planted trees during the heat of the summer is to water them up to three times per week, in the absence of precipitation. Though, you want to make sure the soil is not completely saturated with water at all times.

Larger, established trees may not need much water at all but extremely high temperatures and lack of precipitation may warrant watering them every couple of weeks.

When watering your trees, adhere to any water use restrictions you may have in your area and try to maximize the water you do give.

The most important thing is to avoid watering during the heat of the day because much more water is going to be lost in evaporation, said Flocke. Either early in the morning or later in the evening is the best time to water.

An easy tip for watering trees during a drought is to try and mimic what a typical summer looks like for your trees, watering every 10 days to two weeks and knowing that its okay to not be on a set schedule - just like normal summer rain.

Another way you can help your trees manage drought stress is by mulching. Mulch is an easy and inexpensive option to help your trees because it conserves water, regulates soil temperatures, reduces competition from other plants and improves soil health.

In general, apply a layer of mulch no more than two to three inches deep, said Flocke. In reality, the entire area under the canopy could be mulched, but mulching out several feet around the base of the tree, being sure not to let the mulch touch the base of the trunk, will help.

Avoiding tree stress

During times of drought, be extremely cautious not to add additional stresses to your tree, making them more susceptible to secondary insects and diseases. First, do not prune your trees unless absolutely necessary.

What youre trying to do is reduce stress to the tree, so pruning, even when you have to, is adding stress because you are wounding the tree, said Blevins. If youre pruning out live branches or live leaf areas of the tree, youre removing food and the site where the trees root growth hormone is developed, affecting root growth and further stressing the tree at a time where its already too stressed.

According to Blevins, the exception to pruning trees during drought is a completely dead branch or one that is a hazard to its surroundings.

Another common mistake that can be harmful to your trees during a drought is putting out fertilizer.

Just generally applying fertilizers without knowing if there is a deficiency is a really bad idea, said Blevins. If there is not a nutrient deficiency then its not going to help anything and it can actually hurt things and make the tree worse.

During the summer heat, and especially when experiencing drought conditions, monitor your trees for stress symptoms, adding supplemental water when necessary, and continue to enjoy the values that trees add to our lives.

Trees provide an enormous value to us in our landscape, said Flocke. Keeping trees, especially near our homes, can help to reduce overall energy bills, keep us healthier and provide shade for the house. If we lose those trees, we potentially lose benefits that have taken decades to accumulate.

For additional information on caring for your trees during drought conditions, visit tfsweb.tamu.edu/afterthestorm/Drought/ .

View drought conditions in your area at tfsfrd.tamu.edu/ForestDrought/ .

To contact a certified arborist, visit isatexas.com/for-the-public/find-an-arborist/ .

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STRESSING OUT: Drought and trees, explained | Local News | weatherforddemocrat.com - Weatherford Democrat

Somatropin Market to Experience Rapid Growth Between 2022 to 2030 | By -Ipsen, Novo Nordisk A/S, Pfizer Inc, Sandoz International GmbH (Novartis AG) -…

New Jersey, United States-Somatropin Market 2022 2030, Size, Share, and Trends Analysis Research Report Segmented with Type, Component, Application, Region, and Forecast

Human growth hormone advances recovery, propagation, and growth. Expanded utilization of growth hormone and growth hormone mindfulness, which helps in the administration of hormonal lopsidedness problems, improves the market growth. The worldwide Somatropin market size was esteemed at $3,864.00 million out of 2020 and is supposed to reach $9,211.63 million by 2028, enrolling a CAGR of 9.0% from 2022 to 2028. Somatropin is a peptide chemical emitted by the pituitary organ that directs cell development, cell recovery and fix, propagation, and digestion that adds to human development. Somatropin levels in the human body ought to be appropriate for typical development and can be constrained by elements like activity, rest, stress, and low glucose levels. It likewise assists with directing body organization, muscle development and bone development, body liquids, sugar and fat digestion, and recuperation from injury. It additionally assists increment with muscle strength and execution.

Many organizations are putting resources into R&D to foster a Somatropin that makes fewer side impacts and will be a drawn-out treatment. The development in the market is because of the expansion in illnesses connected with Human Growth Hormone (HGH) lack, ascend being used of maturing chemicals, endeavors taken by states and different confidential associations to spread consciousness of Somatropin lack, areas of strength for and. Different factors, for example, expanded attention to the treatment cycle, an expanded number of wellbeing problems, and expanded neuropsychiatric cases are projected to work on the development of the Somatropin market. The fast development of new Somatropin books is supposed to drive the Somatropin market development.

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Somatropin is a peptide chemical liable for development excitement, cell propagation, and cell recovery in people and is consequently significant for the human turn of events. Growth Hormone deficiency in people is caused when the pituitary organ doesnt blend sufficient convergence of hGH. This lack in people is treated by regulating recombinant Somatropin by subcutaneous infusion. Different hereditary problems, including Prader-Willi disorder and Turner condition, may likewise cause Somatropin lack in people, prompting deferred pubescence and more limited than-normal level.

Somatotropin, likewise called as Growth hormone (GH) or human growth hormone, is a protein hormone of around 190 amino acids that is combined and discharged by cells called somatotrophs in the front pituitary. It helps control a few complex physiologic cycles, including growth and digestion. Additionally, it is liable for the growth of the multitude of tissues in the body including the bones. Somatotropin is utilized as a medication for the two people as well as creatures. Somatotropin is a recombinant human growth hormone utilized as a substitution treatment in different states of growth disappointment, growth hormone lack, and shortcomings in kids and grown-ups

Segmentation

The Somatropin deficiency section held the biggest market share in 2019 and was supposed to hold its predominance over the gauge period. This can be ascribed to expanding mindfulness about early conclusion and treatment of GH lack in people and the presentation of novel medications in the hGH market.

In view of the appropriation channel, the Somatropin market has been portioned into the medical clinic drug store, retail drug stores, online drug stores, and specialty drug stores. The clinic drug store section held a huge offer in 2019. This high offer is credited to expanding clinic visits because of rising mindfulness about GH lack among people and the treatment.

Regional analysis

North America is assessed to represent the biggest offer inferable from elements like good repayment situation, laid out medical services foundation, huge government drives, and developing medical care mindfulness. Besides, expanded admittance to novel medications because of the presence of central participants in the locale upholds the North American market. Pfizer, Inc.; Eli Lilly and Company; and Genentech, Inc. are some U.S.- based vital participants that offer an extensive variety of human GH treatments in the district.

Asia Pacific is projected to enlist a critical CAGR over the gauge period. Central members center around acquiring a significant market share in possible nations of the Asia Pacific, for example, Japan and China by acquiring endorsement and the send-off of novel items.

Key PlayersIpsen; Novo Nordisk A/S; Pfizer, Inc.; Sandoz International GmbH (Novartis AG); Ferring Pharmaceuticals; Merck KGaA; Genentech, Inc. (Roche); Teva Pharmaceutical Industries, Ltd; and Eli Lilly and Company are some of the key players of the market among others.

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Somatropin Market to Experience Rapid Growth Between 2022 to 2030 | By -Ipsen, Novo Nordisk A/S, Pfizer Inc, Sandoz International GmbH (Novartis AG) -...

Eat and sleep to recover from intense exercise – Villages-News

Dr. Gabe Mirkin

Top endurance athletes use hydration, nutrition, and sleep to help them recover from intense exercise (J Funct Morphol Kinesiol, Mar 2022;7(1):22). When you exercise for endurance, you use up glycogen, the sugar that is stored for energy in your muscles, and you damage muscle fibers. You will recover faster from intense exercise by:

Eating a high-carbohydrate meal as soon as possible after you finish a competition or intense workout (Nutrients, Mar 22, 2022;14(7):1320;J Exercise and Nutrition, May 2022;5(2);Nutr Rev, 2018 Apr 1;76(4):243-259;Int J Sprt Nutr and Ex Metab, 2010;20:515-532).

Adding protein to that meal hastens recovery even more (Sports Science Exchange, 2002;87:15;Physiologie Applique, Nutrition et Mtabolisme, February 2008;J Strength Cond Res, Aug 2010;24(8):2192-202).

Taking caffeine-rich foods and drinks such as coffee or chocolate may help muscles replenish their stored sugar sources faster (J of Applied Physiology, 2008;105:7-13).

Drinking lots of fluids is also necessary for a faster recovery (J Hum Kinet, July 28, 2021;79:111-122;Eur J Sport Sci, 2014;14:S69-S76;J of Sports Sciences, January 2004).

Going to sleep soon after you finish intense exercise hastens recovery (Int J Sports Med, Aug 2019;40(8):535-543;Int J Environ Res Public Health, 2021;18:11698). Intense exercise damages muscles, which causes your pituitary gland to produce large amounts of human growth hormone (HGH) that helps repair injured tissues, and you produce the largest amounts of HGH when you sleep (J Pediatr, 1996 May;128(5 Pt 2):S32-7). A ninety-minute recovery nap after you exercise also improves your ability to reason and think (Sleep, April 12, 2019;42(1):A71-A72).

Train by Stressing and RecoveringAll training for sports that require strength or endurance is based on stress and recover. You take an intense workout to damage your muscles so that when they heal, they will become stronger and have greater endurance. You know that you have caused Z-line muscle fiber damage because you will feelDelayed Onset Muscle Soreness (DOMS)4-24 hours after you stop exercising. Then you exercise at a very low intensity for as many days as it takes for muscles to heal. Only when your muscles feel fresh again do you take your next intense workout.

My RecommendationsAs long as your post-intense-exercise meal contains lots of protein and carbohydrates, it doesnt matter much what you eat (Am J Clin Nutr, Jan 2017;Med Sci Sports Exerc, Oct 2008;40(10):1789-94). Hamburgers, French fries and other fast foods helped athletes recover just as quickly from hard workouts as sports nutrition products such as Gatorade, PowerBars or Clif Bars (Int J of Sprt Nutr and Exe Metab, March 26, 2015). The fastest way to get muscles to heal is to have your body produce lots of insulin, which you will get when you take in any source of carbohydrates. You must also provide a supply of protein to repair the damaged tissue. Insulin drives sugar into cells to be used for energy, and it also drives protein building blocks called amino acids into the muscle cells to help them heal faster. Add salt on hot days, when your muscles feel excessively fatigued or you develop cramps (Can J Appl Physiol, 2001;26 Suppl:S236-45). SeeRecovery: the Key to Improvement in Your Sport

Dr. Gabe Mirkin is a Villager. Learn more at http://www.drmirkin.com

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Eat and sleep to recover from intense exercise - Villages-News