Fauci Lied About Locking Down, We Have the Receipts – The Clay Travis & Buck Sexton Show

BUCK: Dr. Fauci is making the rounds once again. This guy is I have never so thoroughly despised an American official in public life because I think that Fauci has done more damage to more people and is unrepentant about it. In fact, he thinks hes a hero. And hes a liar, folks. Its not up for debate whether hes a liar. Lets remember one thing. At the beginning of the pandemic, he said masks are basically a joke, which, by the way, newsflash, in case anyone doesnt know, is true. They dont

CLAY: A hundred billion percent true.

BUCK: And that was when Fauci was saying, at the beginning of the pandemic, after decades of being a public health bureaucrat, but then it became clear, oh, the masks are a compliance tool, the masks get everyone scared, the masks get everyone to shut up and do what theyre told. And so, he said, Well, I had to lie about that, I had to lie and tell everybody that masks werent that important, werent useful because we were gonna run out.

So, his excuse for the mask flip-flop is, Im a big, fat liar, or in his case, a little evil troll liar, but the point is, that was what he said. Now when people are saying, hold on. Were going into a recession, were in a recession, inflation is really bad, turns out shutting down the economy and just paying people is a crazy idea. And some of us said it at the time but we were shouted down as grandma killers. Now Faucis trying to play this game where he tells everybody he never recommended locking anything down. That was not what he did.

Fauci on school lockdowns: I didnt recommend locking anything down pic.twitter.com/0KSVzJ1bAV

The Post Millennial (@TPostMillennial) July 26, 2022

BUCK: Clay, he is such a little liar. He is so disgraceful. And they still put him on TV all the time, they still want to have Fauci with these pronouncements. Schools, the real takeaway of the covid pandemic is schools never should have closed, never should have closed and that they did this because Democrats wanted people to be scared, they wanted to beat Trump, they wanted to put old man Magoo Biden in place. Thats whats really happened here.

CLAY: Im still furious about the fact that schools got shut down, and Fauci lied when he said, Go back and look at my past statements. He actually did advocate for shutdowns, and you know what? I think we have a clip of him advocating for shutdowns as well, but well ask Donald Trump about this. On Friday hes scheduled to be on the program with us, and I bet Trump will tell us, Hey, yeah, he did advocate for shutdowns.

BUCK: To clarify for everybody, we just played a clip from the last 24 hours of Fauci telling the American people, I never advocated for locking anything down. That is what Fauci just said, and the evil tyrant Smurf back in October of 2020 was saying this.

FLASHBACK: In October 2020 Fauci said I recommended to the President that we shut the country down. pic.twitter.com/hSW9A4hRd4

The Post Millennial (@TPostMillennial) July 26, 2022

BUCK: So, this is known as being a liar. He is a liar, Clay.

CLAY: And he told everybody go back and look at my statements. You can see I never recommended that the country be shut down. And people said, okay, well, I kind of remember that you did recommend the country be shut down and were pretty vociferous about it. This is whats called receipts, Buck. You say, hey, I never said, and then somebody says wait a minute, actually here you are saying that the country needed to be locked down.

And people like you and me, I was aggressive on the school issue in particular because I knew, as a former public school kid, with a couple of kids in public school, keeping kids from going to school was gonna be a disaster. And also, Buck and you know this, too what was so frustrating about the entire decision to lock down schools was it was based on the response to the Spanish flu back in the early 1900s.

But the difference was the Spanish flu actually impacted younger people at much higher rates than it did older people. We knew by March and April of 2020, Buck, the data was out there that young kids typically were not having issues with covid at all and that this was a disease that primarily attacked the elderly.

BUCK: The truth of the school lockdowns is that there were adults who were part of the Democrat machinery of the teachers unions who didnt want to go in to do their jobs, maybe they were in a panic, maybe they were in hysterics. But the challenge in explaining this to everybody was, why is it that the grocery store clerks down the street from me were showing up for work in March and April and May of 2020, okay? Those grocery stores were open. Cops were doing their jobs. Truckers were doing their jobs.

CLAY: Food delivery people.

BUCK: Food delivery people. But teachers, it was, Oh, Im so scared of covid, according to the teachers unions. Now, I know there are a lot of teachers listening to this who are saying, Buck, I would have gone in, Clay, we didnt want to stay home. Im talking about the union bosses, all right, the ones that wield the power, so much so that Randi Weingarten who now is like, Oh, what do you mean? We shut down schools and that was bad? Who could have seen that coming!

CLAY: And also complaining, ironically enough, Buck, Randi Weingarten, we made school too political. What? You are the person who made schools too political.

BUCK: And she was meeting with Fauci in the White House to determine for everybody whether the schools would be open. Aside, we got a lot of people to want weigh in on the HGH CrossFit. We got some 55-year-olds that are doing back squats with 400 pounds, Clay.

CLAY: I understand there are some freakish dudes out there that can add massive amounts of muscle suddenly at the age of 50. Im not one of them. And I dont think most people are them.

BUCK: But, anyway, maybe well get to some of that in a moment. I just think, though, what we just played for you, this isnt a minor thing, right? Telling the American people, I never Fauci saying, I never advocated for lockdowns, and then we can play you a clip where hes saying, Oh, I told the president to lock everything down! How can anyone listen to this person still? He is the worst. You know whos seen it all along? Its why I love him. Senator Rand Paul. Hes known what a smarmy little tyrant Fauci is all along.

CLAY: No doubt, and its just funny to me that he says, Go look at all my comments, youll never find it, and then we find it almost instantaneously. Thats the great thing about

BUCK: audio clips for em, you know you do, Clay, youd say, You need the science, the data, difficult decisions being made about mitigation, and its just the usual BS magic show that he pulls all the time.

CLAY: Yesterday, Buck, he said that he believes every kid needs to be in a mask again going back to school. Thats what he said.

BUCK: He is advocating for mass child abuse because he is so stubborn, pigheaded, and narcissistic that he will not admit he was wrong about everything and made everything worse.

CLAY: Again, I think youre right and weve talked about this for a long time just based on giving Senator Rand Paul and Jim Jordan and others the House and the Senate the ability to really grill Dr. Fauci, you should be voting Republican this fall. Because he is the most destructive bureaucrat in American history, and he needs I really believe this. I think he should be charged with perjury for lying to Congress.

I think that he should be charged with conspiracy over attempts It seems quite clear to me based on some of these emails to hide the gain-of-function tax dollars that we sent to China. Fauci, in my opinion, has committed criminal violations and should be charged with them. At a minimum, he should be hauled in front of Congress, not allowed to tap out and grilled for hours about his inconsistent statements and lies. I just think it has to happen. And thats a reason alone to vote red this fall, even if you werent fired up about many other things that Joe Biden has done. Fauci by himself needs to make this happen.

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Fauci Lied About Locking Down, We Have the Receipts - The Clay Travis & Buck Sexton Show

Bear blood contains ‘superhero’ components that preserve muscle mass during hibernation – Study Finds

HIROSHIMA, Japan All it takes is a few weeks of lounging and putting off the gym for humans to start losing muscle mass, but bears sleep all winter long and wake up looking just as buff. Now, exciting new research out of Japan has found that the superhero properties in bear blood can also help humans gain muscle too!

Scientists at Hiroshima University observed muscle gain in cultured human skeletal muscle cells infused with serum from hibernating black bears. They say their work confirms that unique factors activate in a bears blood during winter, sparking their incredible ability to retain their muscles and prevent muscular atrophy despite remaining stationary for five to seven months at a time. However, exactly what these key blood components are is still a mystery.

The use it or lose it phenomenon is a well-accepted physiological principle for the skeletal muscle, which is highly plastic in response to functional demands. Disuse typically leads to skeletal muscle loss and metabolic dysfunction in many animal species, including humans, explains first study Mitsunori Miyazaki, associate professor at Hiroshimas Graduate School of Biomedical and Health Sciences, in a university release.

In contrast, hibernating animals are likely better described to be under the no use, but no lose phenomenon, in that there is potential resistance to muscle atrophy during continued disuse conditions.

In collaboration with researchers from Hokkaido University, study authors discovered that serum extracted from the blood of hibernating Japanese black bears actively weakens the destruction mechanism that dictates muscular degradation.

A living beings muscle mass is generally influenced by the dynamic balance between the synthesis and degradation of its proteins. When a bears serum interrupts this balance, cultured muscle cells display significant protein growth after just 24 hours of treatment. Importantly, serum taken from bears during the summer months did not have this same effect on muscle cells.

Researchers theorize the diminished capacity of the muscles destruction mechanism is due to the suppression of the MuRF1 gene (Muscle RING-finger protein-1), which scientists consider the switch that jumpstarts the shredding of unused muscles. According to the theory, the activation of the Akt/FOXO3a (protein kinase B/Forkhead box class O 3a) axis takes care of the elevation of protein synthesis mediating the suppression of MuRF1 expression.

The team also found higher levels of the growth factor hormone IGF-1 (insulin-like growth factor-1) in the hibernating bear serum. Study authors say this hormone is a potential upstream factor, inducing the activation of the Akt/FOXO3a axis. Meanwhile, earlier studies have recorded IGF-1 concentration variations in bear serum depending on the season. Those earlier projects noted that IGF-1 concentrations were highest during the active summer months and at their lowest during the early weeks of hibernation (before increasing again near the end of the winter).

Prof. Miyazaki and his team redirected their efforts elsewhere after properly correcting their calculations regarding GF-1 concentration levels within the hibernating bear serum. They believe that it is quite possible that the higher IGF-1 concentrations in the study are the result of a reduction in the serums water content due to any number of other causes, including dehydration.

We have indicated that some factor present in hibernating bear serum may regulate protein metabolism in cultured human skeletal muscle cells and contribute to the maintenance of muscle mass. However, the identification of this factor has not yet been achieved, Prof. Miyazaki adds.

I wanted to do research that would lead to the development of effective rehabilitation and training methods, Prof. Miyazaki concludes, adding that this is the reason he started exploring hibernations secrets.

By identifying this factor in hibernating bear serum and clarifying the unexplored mechanism behind muscles that do not weaken even without use in hibernating animals, it is possible to develop effective rehabilitation strategies in humans and prevent becoming bedridden in the future.

The study is published in PLOS ONE.

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Bear blood contains 'superhero' components that preserve muscle mass during hibernation - Study Finds

What Are Hormones and What Do They Do? – Health Essentials

People can blame out-of-whack hormones for every medical problem under the sun. But how can you really tell if your hormone levels are off? There are 50 different types of hormones affecting your bodys systems. Endocrinologist Divya Yogi-Morren, MD, discusses the seven hormones you should know about, how to tell if you have a hormonal imbalance and what to do about it.

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Hormones are chemical substances that your body makes in organs called glands. While there are glands throughout your body, the pea-sized pituitary gland at the base of your brain is the puppet master. Its responsible for making hormones that tell the other glands what hormones they should make, explains Dr. Yogi-Morren.

For example, your pituitary gland makes:

When you have a hormonal imbalance, the gland making your hormones produces too much or not enough of that specific hormone. Dr. Yogi-Morren lists seven hormones that have VIP status in our bodies, what these hormones do and signs your body isnt making the right amount.

Cortisol is a stress hormone. Cortisol levels increase in response to stress, and its not just medical and physiological stress. Psychological stress can increase cortisol as well, says Dr. Yogi-Morren.

Cortisol is a hormone jack-of-all-trades. It:

A good nights sleep is important for cortisol regulation, she adds. Cortisol is the get-up-and-go hormone, and theres a circadian pattern to cortisol release:

Signs of cortisol deficiency include:

Signs of too much cortisol include:

Estrogen is known as a sex hormone. It affects sexual development and function. Dr. Yogi-Morren says its also important for bone health.

When women and people assigned female at birth go through puberty, estrogen helps them develop secondary sexual characteristics (sex characteristics not directly related to reproduction), such as:

If you dont have enough estrogen, you may enter menopause. Signs of menopause include:

Testosterone is another sex hormone. Like estrogen, it also helps keep bones healthy.

When men and people assigned male at birth go through puberty, testosterone helps them develop secondary sexual characteristics, such as:

Hypersexuality is a symptom of too much testosterone, but its rare. Whats more common, Dr. Yogi-Morren says, is testosterone levels that decline as men get older. Signs of low testosterone include:

Thyroid hormones control your bodys metabolism. They help transform the food we eat into energy.

Common symptoms of hypothyroidism, or underactive thyroid, include:

Common symptoms of hyperthyroidism, or overactive thyroid, include:

Growth hormone affects your height. Dr. Yogi-Morren says its most important during puberty, although too much or too little in adults can also cause problems.

Causes of growth hormone deficiencies include:

Signs of growth hormone deficiency include:

Sometimes, for people with pituitary disease, we may correct all other hormonal imbalances except growth hormone because its rare that adults need it, explains Dr. Yogi-Morren. But when its the only thing left after symptoms dont resolve, we replace it, and people may feel a lot better.

Too much growth hormone in adults can lead to a condition called acromegaly, which can cause:

This important hormone comes from your pancreas and regulates blood sugar (glucose).

It also allows the cells in our muscles, fat and liver to take up the glucose absorbed in the blood. The glucose then gives these cells energy, says Dr. Yogi-Morren. Insulin also affects other metabolic processes such as how the body uses fat and protein.

A pancreas not meeting its insulin quota causes Type 1 diabetes. This condition most often occurs before adulthood but can develop at any time. Symptoms of Type 1 diabetes include:

In Type 2 diabetes, your pancreas makes enough insulin, but your body doesnt respond to it like it should (insulin resistance). Signs of Type 2 diabetes include:

Melatonin is important during sleep and helps with your bodys internal clock. Exposure to daylight affects how much melatonin your body releases.

Your body makes less melatonin as you age. If you have sleep disturbances, it could be a sign that your body doesnt make enough melatonin.

If you think you have a hormonal imbalance, Dr. Yogi-Morren advises seeing your healthcare provider. Discuss your symptoms and get your hormone levels checked. Treatments range from medications to surgery when a tumor causes a hormonal imbalance.

Diabetes is a great example of a treatable hormonal imbalance. We have so many more treatment options than ever before.

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What Are Hormones and What Do They Do? - Health Essentials

Growth Hormone Market Analysis by Recent Developments and Business Outlook 2022 This Is Ardee – This Is Ardee

The Growth Hormone market report provides an in-depth analysis of parent market trends, macroeconomic indicators and governing factors, as well as market attractiveness by segment. The Growth Hormone is a compilation of first-hand information, qualitative and quantitative assessment by industry analysts, inputs from industry experts and industry participants across the value chain. Regional estimates and forecasts and trend analysis for each country and region are also available in the market. For enhanced decision-making, the research also provides in-depth details regarding the COVID-19 scenario and its influence on the market.

The Growth Hormone is expected to register a CAGR of around 7.6%, during the forecast period 2022 to 2027.

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Market Segmentation:

Prime Companiesin the Growth Hormone: Eli Lilly and Company, EMD Serono Inc., F. Hoffmann-La Roche AG, Ferring B.V., Genentech Inc., Ipsen, Merck KGaA, Novartis AG, Novo Nordisk, Pfizer Inc. and Sandoz, , TEVA PHARMACEUTICAL INDUSTRIES., Anhui Anke Biotechnology (Group) Co.,

Segment by Type

Short-Acting Growth Hormones

Long-Acting Growth Hormones

Segment by Application

Growth Hormone Deficiency

Idiopathic Short Stature

Turner Syndrome

Small For Gestational Age

Prader-Willi Syndrome

Others

The report Growth Hormone 2022 Industry provides key statistics on the current status of the Growth Hormone manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. The study covers market growth history, development trends, competitive landscape analysis, and key regions development status.

Regions Are Covered by Growth Hormone Report 2022 To 2028:

North America (the United States, Canada, and Mexico)Europe (Germany, France, UK, Russia, and Italy)Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)South America (Brazil, Argentina, and Colombia)Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

Key highlight

Chapter 1: Market overview

Chapter 2: Global Growth Hormone Market

Chapter 3: Regional analysis of the Global Growth Hormone industry

Chapter 4: Growth Hormone Market segmentation based on types and applications

Chapter 5: Revenue examination based on types and applications

Chapter 6: Market share

Chapter 7: Modest Landscape

Chapter 8: Drivers, Fetters, Tests, and Chances

Chapter 9: Uncultured Margin and Price Analysis

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The #1 Thing That Gives You Visceral Fat Say Experts Eat This Not That – Eat This, Not That

Visceral fat is dangerous "active fat" stored deep in the abdomen, surrounding organs such as the liver and intestines. Unlike "pinchable" subcutaneous fat (for example, the fat on your thighs), belly fat is linked to concerning health conditions such as heart disease, fatty liver, and diabetes. But why? "Visceral (belly) fat secretes greater levels of adipokines chemicals that trigger inflammation and releases more fatty acids into the bloodstream," says Evelyn Parr, research fellow in exercise metabolism and nutrition, Mary MacKillop Institute for Health Research, Australian Catholic University. "Whereas the fat cells in the leg region, and the pinchable, subcutaneous layers of fat around the middle, store fatty acids within themselves, rather than pushing them into the circulation. The fat around the hips and legs is more passive, meaning it releases fewer chemicals into the body." Here's the number one cause of visceral fat, according to experts. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Measuring your waist circumference is a good place to start: "You can use a tape measure to get a good idea of whether you've packed on too many pounds around your abdomen," says Julie Chen, MD. "Place the tape measure around your belly button and level the sides at the top of your hip bones. For men, a waist measurement of 40 inches is a sign of too much visceral fat. For women, a waist measurement of 35 inches is considered high risk."

If you're not getting enough sleep, losing weightespecially belly fatis like playing a videogame on "hard" mode. "Sleeping too little increases belly fat by suppressing the release of growth hormone," says personal trainer Cathe Friedrich. "Growth hormone is an anabolic hormone that boosts muscle growth, but it's also a fat-burning hormone that helps keep your tummy and waistline trim. Growth hormone levels rise during deep sleep, so if you're not getting enough sleep, growth hormone levels can be affected. This makes it harder to build muscle and lose body fat even if you lift heavy weights."

Exercise is important for getting visceral fat under controlif you're not moving, the inches will continue to add up. "The starting point for bringing weight under control, in general, and combating abdominal fat, in particular, is regular moderate-intensity physical activity at least 30 minutes per day (and perhaps up to 60 minutes per day) to control weight and lose belly fat," says Harvard Health. "Strength training (exercising with weights) may also help fight abdominal fat. Spot exercising, such as doing sit-ups, can tighten abdominal muscles, but it won't get at visceral fat."

"Drinking beer and spirits is linked to elevated levels of visceral fat the harmful type of fat that is associated with an increased risk of cardiovascular disease, metabolic syndrome, and other health complications whereas drinking wine shows no such association with levels of this harmful fat and may even be protective against it, depending on the type of wine consumed," says Brittany Larsen, Ph.D. Candidate in Neuroscience & Graduate Assistant, Iowa State University.6254a4d1642c605c54bf1cab17d50f1e

While calories are absolutely not the be-all end-all of weight loss, losing belly fat will be difficult (if not impossible) with a diet high in ultra processed carbohydrates, sugar, and junk food. Kerry Stewart, Ed.D. , director of Clinical and Research Physiology at Johns Hopkins recommends restricting carbs over counting calories. "Ultimately, you need to pick a healthy eating plan you can stick to. The benefit of a low-carb approach is that it simply involves learning better food choicesno calorie-counting is necessary. In general, a low-carb way of eating shifts your intake away from problem foodsthose high in carbs and sugar and without much fiber, like bread, bagels and sodasand toward high-fiber or high-protein choices, like vegetables, beans and healthy meats."

Ferozan Mast

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Injection Pen Market Size, Scope, Growth Opportunities, Trends by Manufacturers And Forecast to 2029 This Is Ardee – This Is Ardee

New Jersey, United States TheInjection PenMarket research guides new entrants to obtain precise market data and communicates with customers to know their requirements and preferences. It spots outright business opportunities and helps to bring new products into the market. It identifies opportunities in the marketplace. It aims at doing modifications in the business to make business procedures smooth and make business forward. It helps business players to make sound decision making. Injection Pen market report helps to reduce business risks and provides ways to deal with upcoming challenges. Market information provided here helps new entrants to take informed decisions making. It emphasizes on major regions of the globe such as Europe, North America, Asia Pacific, Middle East, Africa, and Latin America along with their market size.

Such unique Injection Pen Market research report offers some extensive strategic plans that help the players to deal with the current market situation and make your position. It helps in strengthening your business position. It offers better understanding of the market and keep perspective to aid one remain ahead in this competitive market. Organizations can gauze and compare their presentation with others in the market on the basis of this prompt market report. This market report offers a clarified picture of the varying market tactics and thereby helps the business organizations gain bigger profits. You get a clear idea about the product launches, trade regulations and expansion of the market place through this market report.

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Key Players Mentioned in the Injection Pen Market Research Report:

Novo Nordisk, Sanofi, ELI Lilly and Company, Merck, Ypsomed, Astrazeneca, F.Hoffman-La Roche, Becton, Dickinson and Company, Owen Mumford, Novartis.

Injection PenMarket report consists of important data about the entire market environment of products or services offered by different industry players. It enables industries to know the market scenario of a particular product or service including demand, supply, market structure, pricing structure, and trend analysis. It is of great assistance in the product market development. It further depicts essential data regarding customers, products, competition, and market growth factors. Injection Pen market research benefits greatly to make the proper decision. Future trends are also revealed for particular products or services to help business players in making the right investment and launching products into the market.

Injection PenMarket Segmentation:

Injection Pen Market by Type

Disposable Injection Pen Reusable Injection Pen

Injection Pen Market by Therapy

Diabetes Growth Hormone Therapy Osteoporosis Fertility Other Therapies

Injection Pen Market by End User

Home Care Hospitals & Clinics

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For Prepare TOC Our Analyst deep Researched the Following Things:

Report Overview:It includes major players of the Injection Pen market covered in the research study, research scope, market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the Injection Pen market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the Injection Pen market are discussed.

Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type:This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application:Besides an overview of the Injection Pen market by application, it gives a study on the consumption in the Injection Pen market by application.

Production by Region:Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region:This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

Company Profiles:Almost all leading players of the Injection Pen market are profiled in this section. The analysts have provided information about their recent developments in the Injection Pen market, products, revenue, production, business, and company.

Market Forecast by Production:The production and production value forecasts included in this section are for the Injection Pen market as well as for key regional markets.

Market Forecast by Consumption:The consumption and consumption value forecasts included in this section are for the Injection Pen market as well as for key regional markets.

Value Chain and Sales Analysis:It deeply analyzes customers, distributors, sales channels, and value chain of the Injection Pen market.

Key Findings:This section gives a quick look at the important findings of the research study.

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Injection Pen Market Size, Scope, Growth Opportunities, Trends by Manufacturers And Forecast to 2029 This Is Ardee - This Is Ardee

Global Hormone Refractory Breast Cancer Market Report Shows Demand to Boost Industry Growth from 2022 to 2028 This Is Ardee – This Is Ardee

The Global Hormone Refractory Breast Cancer Market has revealed the release of a recent study, which contains geographical and financial market data and is expected to rise in importance during the projected period, i.e., 2022 and 2028. The research will help investors comprehend the industrys latest trends and better understand the market scenario. The analysis precisely describes the geographical scope of the worldwide Hormone Refractory Breast Cancer market.

The studys global Hormone Refractory Breast Cancer market calculations have been analyzed by considering the effect of different political, monetary, educational, social, technological, and government regulations. It is accomplished by examining their product offerings, market size & share, Net revenue experts advice, and growth rate.

The Hormone Refractory Breast Cancer market is divided into the following segments:

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Segmentation depending on type:

Segmentation based on applications:

Segmentation by country:

With a thorough player portfolio for each, the following main market participants are listed in the report:

The following are some of the reports practical techniques:

The Survey Responds to the Following Queries:

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Important Elements of the Hormone Refractory Breast Cancer Market:

The examination includes Value chain analysis, Porters Model, and PESTEL study to give a deeper glimpse at the Hormone Refractory Breast Cancer industry. The report comprehensively analyzes manufacturers and their market percentage in the global market. The research also carries regional presence, the product offered, strategic development, and economic statements of the players to evaluate market competitiveness.

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Global Hormone Refractory Breast Cancer Market Report Shows Demand to Boost Industry Growth from 2022 to 2028 This Is Ardee - This Is Ardee

Fundraising event held for local 4-year-old with rare blood disorder – Lynchburg News and Advance

When he was just a year old, Waylon Means underwent two surgeries for hip dysplasia. Afterwards, doctors found out he had a growth hormone deficiency because he was so small, his parents Aaron and Lauren Means, of Lynchburg, said.

After continuous blood draws, Waylon was diagnosed with Fanconi Anemia a rare genetic blood disorder that leads to Aplastic Anemia and an increased risk of Leukemia when he was 3 years old.

In an effort to raise money for his medical expenses, a Roanoke-based nonprofit held a car, truck and bike show Saturday for him and his family at Tree of Life Ministries on Greenview Drive.

HopeDriven, a 501c3 nonprofit, holds events such as car shows, toy drives and other community events to raise money for children ages 18 and younger whove experienced a life-altering event such as a disease, accident or sickness.

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So anytime we run an event, the money that we raised is donated directly towards them and their medical expenses and associated costs, HopeDrivens president Kevin Jenkins said.

The nonprofit was established in 2019 after Jenkins held a car show to benefit a child with Leukemia in Vinton and raised $11,000 for her medical expenses.

Waylon must undergo regular blood draws every two months and bone marrow biopsies every six to twelve months depending on blood results.

He will be going to Cincinnati Childrens Hospital this Wednesday to undergo further testing and treatment, his father said.

There, the family will meet with an endocrinologist, hematologist and oncologist about what the next steps are for Waylon.

Lauren Means said Fanconi Anemia makes Waylon highly susceptible to cancer, especially leukemia. She said it is expected that by the time he is 8 years old, Waylon may require a bone marrow transplant.

Were very lucky to have gotten in as soon as we did to meet with the people who specialize in his type of Fanconi Anemia, she said. The way the steps have happened has been nothing but a blessing. To be in a situation like this and to get news like that and to not know what the future holds, were in good hands.

Looking around at the hundreds of people who came out to support her son, she said she had no words.

We were praying, she said. We got here and its been one of the biggest turnouts theyve had. Its incredible. Theres so many people who we dont even know who have shown up.

Aaron Means said hes been amazed to see how many people have shared about the event and about Waylon on Facebook and have wanted to support the family through his Go Fund Me page.

Its just been a blessing, he said. The Lord has really done a lot of good work for us and for Waylon and putting all this stuff together.

The event brought in a variety of vehicles such as motorcycles, muscle cars, classic cars from the 50s, 60s and 70s, Jeeps, ATV, trucks and foreign cars.

We have tons of variety of cars, we try to bring older and newer cars together and bridge that gap because at the end of the day, were using our passion for vehicles to raise money for this kid, Jenkins said.

Along with various local food vendors, the event held Hot Wheel Racing for children and an exhaust competition at the end that Jenkins said was sure to get everyone ramped up.

And then at the end of every show, the kid that we sponsor if theyre here or they have a family representative here, they pick the best in show for us, he said.

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Fundraising event held for local 4-year-old with rare blood disorder - Lynchburg News and Advance

expert reaction to study looking at menopausal hormone therapy after early-stage breast cancer, and breast cancer recurrence – Science Media Centre

July 20, 2022

An observational study published in the Journal of the National Cancer Institute looks at the use of hormone therapy After Early Breast Cancer.

Prof Paul Pharoah, Professor of Cancer Epidemiology, University of Cambridge, said:

This is a large, observational study (that is it is not a randomised controlled trial) investigating the potential association between vaginal estrogen therapy or menopausal hormone therapy use in women with early breast cancer and recurrence of the breast cancer. All the women with cancer had been treated with some form of anti-estrogen therapy that can be associated with symptoms of the menopause. Most of the women who had some form of treatment for menopausal symptoms used vaginal estrogen therapy (1,222) and only 117 had used menopausal hormone therapy in the form of patches or tablets.

The numbers of women using menopausal hormone therapy in the form of patches or tablets was too small to make any meaningful inferences about the effects on recurrence.

The main findings were that vaginal estrogen therapy was not associated with an increased risk of disease recurrence. However there was some evidence that the subgroup of women whose breast cancer was treated with an aromatase inhibitor are at a slightly increased risk of recurrence.

The data on which the study is based are of a high quality and the analyses appear to be sound. These results are reassuring for women who get menopausal symptoms as a result of treatment of their breast cancer with tamoxifen, but they cannot definitively rule out a small increase in risk as all observational studies are prone to some forms of bias and the interpretation of the results can be difficult.

[An example of why the results may not be as straightforward as they seem. Subtle but could be important:- For example, women who use vaginal estrogen therapy or menopausal hormone therapy are likely to have more severe symptoms. Such symptoms may indicate that the breast cancer therapy they are taking is more effective and so these women might be expected to have better outcomes rather than the similar outcomes observed in this study. This is conjecture, but the truth cannot be known outside a randomised controlled trial. A fundamental problem with observational studies is small risks v hard to rule in or out.]

Dr Channa Jayasena, Consultant Reproductive Endocrinologist, Imperial College London, said:

Breast cancer treatment often involves blocking actions of the female hormone, oestrogen. This is because oestrogen can feed the growth of breast tumours. Unfortunately, women surviving breast cancer may feel symptoms of low oestrogen like vaginal dryness, low mood or hot flushes. The authors have conducted a huge study of over 8000 women treated for breast cancer in Denmark. It has been analysed appropriately, and their results look credible.

20% of these women also took vaginal creams containing oestrogen; very little of this cream escapes to the rest of body. 2% of women with breast cancer took HRT tablets containing oestogen, which would certainly raise oestogen levels in the whole body. Overall, their results have failed to demonstrate risk associated with giving HRT tablets. However this was an observational study. It is therefore possible that doctors gave HRT tablets to those women who they were most confident would not have breast cancer coming back (because the tumour was very small and not aggressive). So, it seems premature to recommend HRT to women after breast cancer based on just this study. However, the results suggest that future trials looking at the safety of HRT are warranted.

Dr Annice Mukherjee, Consultant Endocrinologist, Spire Manchester Hospital, said:

It should be emphasised that this study includes women with early-stage breast cancer who did not receive chemotherapy. They are therefore a highly selected group with a lower risk of recurrence than women with more advanced disease at presentation who are treated with chemotherapy.

The data are very reassuring for the use of vaginal oestrogen therapy and this is consistent with previous data. The long follow-up times are also extremely helpful and reassuring, although there remains some question about women who are treated with aromatase inhibitors.

The numbers in the systemic menopausal hormone therapy (MHT) groups are far too small to make any new conclusions about safety of systemic MHT. Also, as with all the previous observational studies there is effectively a healthy user bias, because women who were prescribed MHT had smaller tumours and other parameters suggesting they were at the lowest overall risk of recurrence than non-users of MHT or those excluded from the analysis with more advanced disease at presentation.

The study supports an individualised approach to managing menopause symptoms in women who have had breast cancer and the nuances mean that decisions should be made by specialists involved in the multidisciplinary care of breast cancer survivors.

Systemic or Vaginal Hormone Therapy After Early Breast Cancer: A Danish Observational Cohort Study by Sren Cold et al. was published in the Journal of the National Cancer Institute at 05:01 UK time on Wednesday 20 July 2022.

DOI: 10.1093/jnci/djac112

Declared interests

Prof Paul Pharoah: I have no conflicts of interest to declare.

Dr Channa Jayasena: No conflicts.

Dr Annice Mukherjee: No declarations other than being a Society for Endocrinology member.

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expert reaction to study looking at menopausal hormone therapy after early-stage breast cancer, and breast cancer recurrence - Science Media Centre

Climate change is making plants more stressed. But this hormone could help them out – ZME Science

Plants have the capacity to grow continually for hundreds of years, and always towards the light of the sun, which gives them the energy to sprout and grow. But the changing conditions imposed by climate change are altering the normal growth of plants, making them more stressed as they have to cope with higher temperatures and extreme weather events.

Looking for solutions, scientists from US Riverside are now exploring the mechanism through which plants produce salicylic acid, hormone and precursor to aspirin that protects plants from environmental hazards. The research team wants to better understand what role this acid plays in plants so that they can encourage plants to produce more of it, which would protect them further from climate change.

Because salicylic acid helps plants withstand stresses becoming more prevalent with climate change, being able to increase plants ability to produce it represents a step forward in challenging the impacts of climate change on everyday life, Katayoon Dehesh, a senior paper author and UCR professor, explains.

Salicylic acid (SA) plays a big role in the growth and development of all plants, increasing their response to stressors both biotic (living) and abiotic (physical). It acts as a stimulant or transmitter of the cell to tolerate environmental stress conditions, such as coldness, heat waves, and dryness, as well as conditions of ammonia tensions and salt stress.

One of the most important effects of salicylic acid is stimulating the production of antioxidants, which increases the plants response and tolerance to various diseases and helps cope with stress. SA also has important physiological roles, such as stimulating flowering and nutrient transfer and controlling protein synthesis.

Humans are also very familiar with this type of acid. Beyond its functions in plants, SA and one of its derivates (commonly known as aspirin) are important pharmacological agents for humans. Its commonly used for acne, psoriasis and warts while aspiring is among the most used medications in the world. Its used to treat fever, pain and inflammation while reducing the risk of heart attack and stroke.

Researchers at UC Riverside published a paper on how plants regulate the production of SA. They focused on a specific plant (Arabidopsis, a commonly used plant in many experiments) but believe they could apply their findings of stress responses in the cells of this plant to many other types of plants, including those used to grow food, thus improving crop resistance amid climate change.

Environmental stress triggers the formation of reactive oxygen species in all living organisms including humans. As with other substances, the key is in the amount. At low levels, this reactive oxygen has an important function in plants, enabling the production of protective hormones like SA, study author Jin-Zheng Wang explained. But the continuous build-up of it can trigger DNA alterations and other problems.

The researchers discovered that heat, drought or persistent sunshine causes the sugar-making apparatus in plant cells to create an initial alarm molecule known as MEcPP. Accumulation of the molecule triggers the production of SA, which begins a chain of protective actions in the cells. Its like plants used a painkiller for their aches and pains.

Going forward, the researchers would like to learn more about the molecule, which is also produced in organisms such as malaria parasites and bacteria. This could allow finding ways to boost the survival of plants amid climate change, which would mean benefits for everyone, considering plants clean the air, offer shade and provide habitats for animals.

The study was published in the journal Science Advances.

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Climate change is making plants more stressed. But this hormone could help them out - ZME Science