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Visceral fat is dangerous "active fat" stored deep in the abdomen, surrounding organs such as the liver and intestines. Unlike "pinchable" subcutaneous fat (for example, the fat on your thighs), belly fat is linked to concerning health conditions such as heart disease, fatty liver, and diabetes. But why? "Visceral (belly) fat secretes greater levels of adipokines chemicals that trigger inflammation and releases more fatty acids into the bloodstream," says Evelyn Parr, research fellow in exercise metabolism and nutrition, Mary MacKillop Institute for Health Research, Australian Catholic University. "Whereas the fat cells in the leg region, and the pinchable, subcutaneous layers of fat around the middle, store fatty acids within themselves, rather than pushing them into the circulation. The fat around the hips and legs is more passive, meaning it releases fewer chemicals into the body." Here's the number one cause of visceral fat, according to experts. Read onand to ensure your health and the health of others, don't miss these Sure Signs You've Already Had COVID.

Measuring your waist circumference is a good place to start: "You can use a tape measure to get a good idea of whether you've packed on too many pounds around your abdomen," says Julie Chen, MD. "Place the tape measure around your belly button and level the sides at the top of your hip bones. For men, a waist measurement of 40 inches is a sign of too much visceral fat. For women, a waist measurement of 35 inches is considered high risk."

If you're not getting enough sleep, losing weightespecially belly fatis like playing a videogame on "hard" mode. "Sleeping too little increases belly fat by suppressing the release of growth hormone," says personal trainer Cathe Friedrich. "Growth hormone is an anabolic hormone that boosts muscle growth, but it's also a fat-burning hormone that helps keep your tummy and waistline trim. Growth hormone levels rise during deep sleep, so if you're not getting enough sleep, growth hormone levels can be affected. This makes it harder to build muscle and lose body fat even if you lift heavy weights."

Exercise is important for getting visceral fat under controlif you're not moving, the inches will continue to add up. "The starting point for bringing weight under control, in general, and combating abdominal fat, in particular, is regular moderate-intensity physical activity at least 30 minutes per day (and perhaps up to 60 minutes per day) to control weight and lose belly fat," says Harvard Health. "Strength training (exercising with weights) may also help fight abdominal fat. Spot exercising, such as doing sit-ups, can tighten abdominal muscles, but it won't get at visceral fat."

"Drinking beer and spirits is linked to elevated levels of visceral fat the harmful type of fat that is associated with an increased risk of cardiovascular disease, metabolic syndrome, and other health complications whereas drinking wine shows no such association with levels of this harmful fat and may even be protective against it, depending on the type of wine consumed," says Brittany Larsen, Ph.D. Candidate in Neuroscience & Graduate Assistant, Iowa State University.6254a4d1642c605c54bf1cab17d50f1e

While calories are absolutely not the be-all end-all of weight loss, losing belly fat will be difficult (if not impossible) with a diet high in ultra processed carbohydrates, sugar, and junk food. Kerry Stewart, Ed.D. , director of Clinical and Research Physiology at Johns Hopkins recommends restricting carbs over counting calories. "Ultimately, you need to pick a healthy eating plan you can stick to. The benefit of a low-carb approach is that it simply involves learning better food choicesno calorie-counting is necessary. In general, a low-carb way of eating shifts your intake away from problem foodsthose high in carbs and sugar and without much fiber, like bread, bagels and sodasand toward high-fiber or high-protein choices, like vegetables, beans and healthy meats."

Ferozan Mast

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The #1 Thing That Gives You Visceral Fat Say Experts Eat This Not That - Eat This, Not That

New Jersey, United States TheInjection PenMarket research guides new entrants to obtain precise market data and communicates with customers to know their requirements and preferences. It spots outright business opportunities and helps to bring new products into the market. It identifies opportunities in the marketplace. It aims at doing modifications in the business to make business procedures smooth and make business forward. It helps business players to make sound decision making. Injection Pen market report helps to reduce business risks and provides ways to deal with upcoming challenges. Market information provided here helps new entrants to take informed decisions making. It emphasizes on major regions of the globe such as Europe, North America, Asia Pacific, Middle East, Africa, and Latin America along with their market size.

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Novo Nordisk, Sanofi, ELI Lilly and Company, Merck, Ypsomed, Astrazeneca, F.Hoffman-La Roche, Becton, Dickinson and Company, Owen Mumford, Novartis.

Injection PenMarket report consists of important data about the entire market environment of products or services offered by different industry players. It enables industries to know the market scenario of a particular product or service including demand, supply, market structure, pricing structure, and trend analysis. It is of great assistance in the product market development. It further depicts essential data regarding customers, products, competition, and market growth factors. Injection Pen market research benefits greatly to make the proper decision. Future trends are also revealed for particular products or services to help business players in making the right investment and launching products into the market.

Injection PenMarket Segmentation:

Injection Pen Market by Type

Disposable Injection Pen Reusable Injection Pen

Injection Pen Market by Therapy

Diabetes Growth Hormone Therapy Osteoporosis Fertility Other Therapies

Injection Pen Market by End User

Home Care Hospitals & Clinics

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Report Overview:It includes major players of the Injection Pen market covered in the research study, research scope, market segments by type, market segments by application, years considered for the research study, and objectives of the report.

Global Growth Trends:This section focuses on industry trends where market drivers and top market trends are shed light upon. It also provides growth rates of key producers operating in the Injection Pen market. Furthermore, it offers production and capacity analysis where marketing pricing trends, capacity, production, and production value of the Injection Pen market are discussed.

Market Share by Manufacturers:Here, the report provides details about revenue by manufacturers, production and capacity by manufacturers, price by manufacturers, expansion plans, mergers and acquisitions, and products, market entry dates, distribution, and market areas of key manufacturers.

Market Size by Type:This section concentrates on product type segments where production value market share, price, and production market share by product type are discussed.

Market Size by Application:Besides an overview of the Injection Pen market by application, it gives a study on the consumption in the Injection Pen market by application.

Production by Region:Here, the production value growth rate, production growth rate, import and export, and key players of each regional market are provided.

Consumption by Region:This section provides information on the consumption in each regional market studied in the report. The consumption is discussed on the basis of country, application, and product type.

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Market Forecast by Production:The production and production value forecasts included in this section are for the Injection Pen market as well as for key regional markets.

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Injection Pen Market Size, Scope, Growth Opportunities, Trends by Manufacturers And Forecast to 2029 This Is Ardee - This Is Ardee

The Global Hormone Refractory Breast Cancer Market has revealed the release of a recent study, which contains geographical and financial market data and is expected to rise in importance during the projected period, i.e., 2022 and 2028. The research will help investors comprehend the industrys latest trends and better understand the market scenario. The analysis precisely describes the geographical scope of the worldwide Hormone Refractory Breast Cancer market.

The studys global Hormone Refractory Breast Cancer market calculations have been analyzed by considering the effect of different political, monetary, educational, social, technological, and government regulations. It is accomplished by examining their product offerings, market size & share, Net revenue experts advice, and growth rate.

The Hormone Refractory Breast Cancer market is divided into the following segments:

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Segmentation depending on type:

Segmentation based on applications:

Segmentation by country:

With a thorough player portfolio for each, the following main market participants are listed in the report:

The following are some of the reports practical techniques:

The Survey Responds to the Following Queries:

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Important Elements of the Hormone Refractory Breast Cancer Market:

The examination includes Value chain analysis, Porters Model, and PESTEL study to give a deeper glimpse at the Hormone Refractory Breast Cancer industry. The report comprehensively analyzes manufacturers and their market percentage in the global market. The research also carries regional presence, the product offered, strategic development, and economic statements of the players to evaluate market competitiveness.

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Global Hormone Refractory Breast Cancer Market Report Shows Demand to Boost Industry Growth from 2022 to 2028 This Is Ardee - This Is Ardee

When he was just a year old, Waylon Means underwent two surgeries for hip dysplasia. Afterwards, doctors found out he had a growth hormone deficiency because he was so small, his parents Aaron and Lauren Means, of Lynchburg, said.

After continuous blood draws, Waylon was diagnosed with Fanconi Anemia a rare genetic blood disorder that leads to Aplastic Anemia and an increased risk of Leukemia when he was 3 years old.

In an effort to raise money for his medical expenses, a Roanoke-based nonprofit held a car, truck and bike show Saturday for him and his family at Tree of Life Ministries on Greenview Drive.

HopeDriven, a 501c3 nonprofit, holds events such as car shows, toy drives and other community events to raise money for children ages 18 and younger whove experienced a life-altering event such as a disease, accident or sickness.

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So anytime we run an event, the money that we raised is donated directly towards them and their medical expenses and associated costs, HopeDrivens president Kevin Jenkins said.

The nonprofit was established in 2019 after Jenkins held a car show to benefit a child with Leukemia in Vinton and raised $11,000 for her medical expenses.

Waylon must undergo regular blood draws every two months and bone marrow biopsies every six to twelve months depending on blood results.

He will be going to Cincinnati Childrens Hospital this Wednesday to undergo further testing and treatment, his father said.

There, the family will meet with an endocrinologist, hematologist and oncologist about what the next steps are for Waylon.

Lauren Means said Fanconi Anemia makes Waylon highly susceptible to cancer, especially leukemia. She said it is expected that by the time he is 8 years old, Waylon may require a bone marrow transplant.

Were very lucky to have gotten in as soon as we did to meet with the people who specialize in his type of Fanconi Anemia, she said. The way the steps have happened has been nothing but a blessing. To be in a situation like this and to get news like that and to not know what the future holds, were in good hands.

Looking around at the hundreds of people who came out to support her son, she said she had no words.

We were praying, she said. We got here and its been one of the biggest turnouts theyve had. Its incredible. Theres so many people who we dont even know who have shown up.

Aaron Means said hes been amazed to see how many people have shared about the event and about Waylon on Facebook and have wanted to support the family through his Go Fund Me page.

Its just been a blessing, he said. The Lord has really done a lot of good work for us and for Waylon and putting all this stuff together.

The event brought in a variety of vehicles such as motorcycles, muscle cars, classic cars from the 50s, 60s and 70s, Jeeps, ATV, trucks and foreign cars.

We have tons of variety of cars, we try to bring older and newer cars together and bridge that gap because at the end of the day, were using our passion for vehicles to raise money for this kid, Jenkins said.

Along with various local food vendors, the event held Hot Wheel Racing for children and an exhaust competition at the end that Jenkins said was sure to get everyone ramped up.

And then at the end of every show, the kid that we sponsor if theyre here or they have a family representative here, they pick the best in show for us, he said.

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Fundraising event held for local 4-year-old with rare blood disorder - Lynchburg News and Advance

July 20, 2022

An observational study published in the Journal of the National Cancer Institute looks at the use of hormone therapy After Early Breast Cancer.

Prof Paul Pharoah, Professor of Cancer Epidemiology, University of Cambridge, said:

This is a large, observational study (that is it is not a randomised controlled trial) investigating the potential association between vaginal estrogen therapy or menopausal hormone therapy use in women with early breast cancer and recurrence of the breast cancer. All the women with cancer had been treated with some form of anti-estrogen therapy that can be associated with symptoms of the menopause. Most of the women who had some form of treatment for menopausal symptoms used vaginal estrogen therapy (1,222) and only 117 had used menopausal hormone therapy in the form of patches or tablets.

The numbers of women using menopausal hormone therapy in the form of patches or tablets was too small to make any meaningful inferences about the effects on recurrence.

The main findings were that vaginal estrogen therapy was not associated with an increased risk of disease recurrence. However there was some evidence that the subgroup of women whose breast cancer was treated with an aromatase inhibitor are at a slightly increased risk of recurrence.

The data on which the study is based are of a high quality and the analyses appear to be sound. These results are reassuring for women who get menopausal symptoms as a result of treatment of their breast cancer with tamoxifen, but they cannot definitively rule out a small increase in risk as all observational studies are prone to some forms of bias and the interpretation of the results can be difficult.

[An example of why the results may not be as straightforward as they seem. Subtle but could be important:- For example, women who use vaginal estrogen therapy or menopausal hormone therapy are likely to have more severe symptoms. Such symptoms may indicate that the breast cancer therapy they are taking is more effective and so these women might be expected to have better outcomes rather than the similar outcomes observed in this study. This is conjecture, but the truth cannot be known outside a randomised controlled trial. A fundamental problem with observational studies is small risks v hard to rule in or out.]

Dr Channa Jayasena, Consultant Reproductive Endocrinologist, Imperial College London, said:

Breast cancer treatment often involves blocking actions of the female hormone, oestrogen. This is because oestrogen can feed the growth of breast tumours. Unfortunately, women surviving breast cancer may feel symptoms of low oestrogen like vaginal dryness, low mood or hot flushes. The authors have conducted a huge study of over 8000 women treated for breast cancer in Denmark. It has been analysed appropriately, and their results look credible.

20% of these women also took vaginal creams containing oestrogen; very little of this cream escapes to the rest of body. 2% of women with breast cancer took HRT tablets containing oestogen, which would certainly raise oestogen levels in the whole body. Overall, their results have failed to demonstrate risk associated with giving HRT tablets. However this was an observational study. It is therefore possible that doctors gave HRT tablets to those women who they were most confident would not have breast cancer coming back (because the tumour was very small and not aggressive). So, it seems premature to recommend HRT to women after breast cancer based on just this study. However, the results suggest that future trials looking at the safety of HRT are warranted.

Dr Annice Mukherjee, Consultant Endocrinologist, Spire Manchester Hospital, said:

It should be emphasised that this study includes women with early-stage breast cancer who did not receive chemotherapy. They are therefore a highly selected group with a lower risk of recurrence than women with more advanced disease at presentation who are treated with chemotherapy.

The data are very reassuring for the use of vaginal oestrogen therapy and this is consistent with previous data. The long follow-up times are also extremely helpful and reassuring, although there remains some question about women who are treated with aromatase inhibitors.

The numbers in the systemic menopausal hormone therapy (MHT) groups are far too small to make any new conclusions about safety of systemic MHT. Also, as with all the previous observational studies there is effectively a healthy user bias, because women who were prescribed MHT had smaller tumours and other parameters suggesting they were at the lowest overall risk of recurrence than non-users of MHT or those excluded from the analysis with more advanced disease at presentation.

The study supports an individualised approach to managing menopause symptoms in women who have had breast cancer and the nuances mean that decisions should be made by specialists involved in the multidisciplinary care of breast cancer survivors.

Systemic or Vaginal Hormone Therapy After Early Breast Cancer: A Danish Observational Cohort Study by Sren Cold et al. was published in the Journal of the National Cancer Institute at 05:01 UK time on Wednesday 20 July 2022.

DOI: 10.1093/jnci/djac112

Declared interests

Prof Paul Pharoah: I have no conflicts of interest to declare.

Dr Channa Jayasena: No conflicts.

Dr Annice Mukherjee: No declarations other than being a Society for Endocrinology member.

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expert reaction to study looking at menopausal hormone therapy after early-stage breast cancer, and breast cancer recurrence - Science Media Centre

Plants have the capacity to grow continually for hundreds of years, and always towards the light of the sun, which gives them the energy to sprout and grow. But the changing conditions imposed by climate change are altering the normal growth of plants, making them more stressed as they have to cope with higher temperatures and extreme weather events.

Looking for solutions, scientists from US Riverside are now exploring the mechanism through which plants produce salicylic acid, hormone and precursor to aspirin that protects plants from environmental hazards. The research team wants to better understand what role this acid plays in plants so that they can encourage plants to produce more of it, which would protect them further from climate change.

Because salicylic acid helps plants withstand stresses becoming more prevalent with climate change, being able to increase plants ability to produce it represents a step forward in challenging the impacts of climate change on everyday life, Katayoon Dehesh, a senior paper author and UCR professor, explains.

Salicylic acid (SA) plays a big role in the growth and development of all plants, increasing their response to stressors both biotic (living) and abiotic (physical). It acts as a stimulant or transmitter of the cell to tolerate environmental stress conditions, such as coldness, heat waves, and dryness, as well as conditions of ammonia tensions and salt stress.

One of the most important effects of salicylic acid is stimulating the production of antioxidants, which increases the plants response and tolerance to various diseases and helps cope with stress. SA also has important physiological roles, such as stimulating flowering and nutrient transfer and controlling protein synthesis.

Humans are also very familiar with this type of acid. Beyond its functions in plants, SA and one of its derivates (commonly known as aspirin) are important pharmacological agents for humans. Its commonly used for acne, psoriasis and warts while aspiring is among the most used medications in the world. Its used to treat fever, pain and inflammation while reducing the risk of heart attack and stroke.

Researchers at UC Riverside published a paper on how plants regulate the production of SA. They focused on a specific plant (Arabidopsis, a commonly used plant in many experiments) but believe they could apply their findings of stress responses in the cells of this plant to many other types of plants, including those used to grow food, thus improving crop resistance amid climate change.

Environmental stress triggers the formation of reactive oxygen species in all living organisms including humans. As with other substances, the key is in the amount. At low levels, this reactive oxygen has an important function in plants, enabling the production of protective hormones like SA, study author Jin-Zheng Wang explained. But the continuous build-up of it can trigger DNA alterations and other problems.

The researchers discovered that heat, drought or persistent sunshine causes the sugar-making apparatus in plant cells to create an initial alarm molecule known as MEcPP. Accumulation of the molecule triggers the production of SA, which begins a chain of protective actions in the cells. Its like plants used a painkiller for their aches and pains.

Going forward, the researchers would like to learn more about the molecule, which is also produced in organisms such as malaria parasites and bacteria. This could allow finding ways to boost the survival of plants amid climate change, which would mean benefits for everyone, considering plants clean the air, offer shade and provide habitats for animals.

The study was published in the journal Science Advances.

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Climate change is making plants more stressed. But this hormone could help them out - ZME Science

Thanks to the internet allowing a view into celebrity lives unlike ever before, Andr the Giant very well may be the last great folk hero. The image of Roussimoff was titanic in nature by virtue of his size, wearing 22 size shoes, with hands that could cover an adult man's entire face, and a towering height rumored to be 7'4" before his numerous back surgeries, but everything else about him was also notoriously huge. He could throw around the 6-foot-8 Big John Studd like nothing, could easily drink a case of wine as a pre-game warm-up, and was said to rip farts that could clear out a whole room. There was no such thing as "go big or go home," because when it comes to Andr the Giant, big is home.

Unfortunately, this meant that the circumstances which led to his colossal size were ignored. Roussimoff was born with acromegaly, a rare condition where the body produces too much growth hormone, causing body tissues and bones to grow more quickly. Not only did Andr spend much of his life in the physically demanding and taxing world of professional wrestling, but he had to travel without any proper accommodations. "It'd be like having to sit on baby furniture for your entire life," Hulk Hogan describes. As much as Andr was beloved the world over, he was also seen as a "freak of nature" by those who were unfamiliar with him. In the doc, "Mean" Gene Okerlund recounts a few touching instances where he confesses Andr would be brought to tears by some of the hurtful comments from strangers, but he'd never let the public see him cry.

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The Daily Stream: Andr The Giant Documentary Proves He Truly Was The Eighth Wonder Of The World - /Film