HGH Injections For Sale

MADRID Because of the hormone changes that occur throughout their lives, women experience sleep problems that differ significantly from those experienced by men. Indeed, 75% to 84% of pregnant women don't sleep well during the third trimester, and up to 80% of women in menopause have symptoms that prevent them from getting a good night's rest. For those seeking to a precision medicine approach, the challenge is to identify the relationship between the different sex-related phenotypes and the sleep conditions.

Irene Cano, MD, PhD, is the coordinator of the sleep department at the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR). She spoke with Medscape Spanish Edition about the significant impact of hormones on sleep disorders in women.

"Reproductive hormones like estrogen and progesterone play a meaningful role in brain functions not only those linked to the regulation of reproduction but also other physiological processes related to the regulation of circadian rhythms, cognitive performance, mood, and sleep. In addition, other hormones for example, prolactin, growth hormone, cortisol, and melatonin have sex-dependent effects on sleep," Cano said.

Girls start puberty at a younger age than boys. As girls enter adolescence, they go to bed later and waking up earlier. So, girls are getting less than the 10 hours of sleep that they should be getting at this stage of life. The result is sleep debt, which gives rise to various problems: poor academic performance, attention-deficit/hyperactivity disorder, obesity, and metabolic problems, to name a few. As Ariadna Farr, RN, a sleep unit nurse, noted at SEPAR's Joint Winter Meeting, "Schools would have to start morning classes later to get adolescents to perform well academically. As the situation is now, half of the kids are falling asleep at their desks."

Cano explained the issue as follows: "In adolescence, along with changes in young women's hormone levels, we begin to see differences between the sexes. The changes in levels of estrogens and progesterone are what's responsible for the changes that, to some extent, cause those disturbances in the quality of our sleep and in the stages of our sleep."

Thus, sleep can be affected by the changes in hormone level that occur during a menstrual cycle. Estrogens, which increase during the follicular phase, are associated with rapid eye movement (REM) sleep, while progesterone, which increases during the luteal phase, increases non-REM sleep. "In the 3 to 6 days prior to menstruation, it's quite common for a woman to report difficulties falling asleep and staying asleep, in connection with a decline in the percentage of time she spends in REM sleep, in the context of premenstrual syndrome. In addition," Cano pointed out, "menstrual bleeding, that loss of blood, is associated with a drop in iron levels, making it more likely that the woman will experience restless legs syndrome."

Medscape Spanish Edition also spoke with Milagros Merino, MD, PhD, president of the Spanish Sleep Society. "The consequences that lack of sleep have on the cardiovascular system we're essentially talking about certain arrhythmias, high blood pressure, thrombosis in some cases, stroke, and heart attack. Lack of sleep also gives rise to endocrine and metabolic issues, like overweight and being at a greater risk of developing diabetes. And as for mental health, we see, among other things, attention and memory problems, emotional lability, and irascibility. Numerous studies have confirmed all of this."

Sleep apnea also deserves mention, Merino added. "Although this disorder is more common in men, we're seeing it more and more now in women, along with the cardiovascular issues that it brings about."

Another cardiovascular risk factor is insomnia, said Merino. "This sleep disorder is more prevalent in women. As hormones constantly change, the ways women sleep constantly change, from one stage of life to the next. They sleep one way in childhood, another way in adolescence, and yet another way in menopause."

During pregnancy, hormone changes are much more pronounced. During the first trimester, progesterone levels increase, making the woman drowsy. On top of that, her sleep is interrupted by more frequent visits to the bathroom as well as greater general discomfort.

In the second trimester, sleep interruptions persist but are not as bad as they were during the first 3 months. In the third trimester, 75% to 84% of pregnant women find it difficult to sleep because of aches and pains, the need to urinate during the night, cramps, and heartburn.

"Major physical changes are happening. When the bladder gets compressed, the woman has to get up and go to the bathroom. There's an interruption in her sleep," Farr explained. In addition, as the pregnancy progresses, the woman gains weight and her body mass index (BMI) increases, which can bring on obstructive sleep apnea, high blood pressure, preeclampsia, and diabetes, if not closely monitored.

Other factors include concomitant treatments, such as contraceptives, and the stages of life, such as pregnancy and lactation. "When a woman of childbearing age has restless legs syndrome, more often than not, this means that she has an iron deficiency that needs to be treated with oral iron supplements," said Merino. "However, there are few medications that can be given to a pregnant woman and RLS is relatively common during pregnancy. So, we have to turn to oral or intravenous iron supplements. Yet another matter is narcolepsy. In these cases, all medications have to be stopped during pregnancy and lactation, as they can be harmful to the baby."

While 1 in 5 menopausal women are asymptomatic, the others experience mild to severe symptoms of apnea that frequently interrupt their sleep. In this stage of life, which begins around age 50 years, the hormones that had provided protection against sleep disruptions start to decrease. As a result, there is a rise in sleep problems, especially insomnia, breathing-related sleep disorders (eg, apnea), and restless legs syndrome.

The prevalence of breathing-related sleep disorders during menopause is attributable to weight gain, the drop in levels of estrogens, and the redistribution of adipose tissue in the body. Other factors also increase a woman's risk of experiencing apnea. They range from stress, depression, and other psychological and psychiatric conditions to health status, medication use, and simply the fact of getting older. "Sleep apnea is more common in men than in premenopausal women. The numbers even out, though, when we compare men against menopausal women," Cano noted.

In women, symptoms of sleep apnea are frequently attributed to menopause. There is some overlap: insomnia, headache, irritability, low mood, decreased libido, fatigue during the day, and feeling sleepy. Only much later is the woman's condition correctly diagnosed as sleep apnea. So, even though presenting with the same complaints, a man will be diagnosed with sleep apnea sooner than a woman will in some cases, around 10 years sooner.

"On the other hand, we'd always thought that, in menopause, insomnia was characterized by awakenings occurring throughout the second half of the night. But perhaps what happens more often is that women are regularly waking up repeatedly over the course of the entire night, as opposed to experiencing a wakefulness that starts early and lasts throughout the night or having a problem falling asleep to begin with," said Merino. "The good news is that hormone replacement therapy can get things back to the way they were. And getting better sleep will help to overcome insomnia."

Insomnia is the most common sleep disorder. It affects 10% to 20% of people, mostly women. "The fact that sleep problems are more prevalent in women can be explained by the fact that among women, there is a higher incidence of conditions that disrupt sleep, such as depression," said Cano.

"Insomnia is much more common in adult women than adult men. And at menopause, women find that the insomnia only gets worse," Merino added. "But around that same age, 50 years old, what we start to see more frequently in men is REM sleep behavior disorder, a type of parasomnia that's a risk marker of degenerative nerve diseases."

Cano emphasized one finding that, though basic, is not well known. "After adjusting for socioeconomic characteristics, the difference between the sexes in reporting sleep problems is cut in half. This suggests that an important factor that explains why there are differences in sleep problems between the sexes is that women's socioeconomic status is generally lower than men's.

"As for sleep apnea in particular," Cano continued, "the kinds of symptoms that women have can be different from the classic ones seen in men snoring, pauses in breathing, and daytime sleepiness; women are being underdiagnosed, and when they are diagnosed, that's happening at a later age and at a higher BMI."

So, it's alarming that, as reported by SEPAR, 90% of women with obstructive sleep apnea are not being diagnosed.

"The majority of research studies on sleep apnea have focused on men given the prevalence of cases and the results have been extrapolated to women. This is why there's still a lot of work to be done in terms of better defining the characteristics specific to each sleep disorder and how they relate to each sex," said Cano. "Being able to identify the relationship between the different sex-related phenotypes and each condition will allow us to take a precision medicine approach tailored to a patient's particular characteristics."

As Merino put it, "The approach to sleep disorders is always personalized. The patient's sex, in and of itself, doesn't have that great of an impact on this approach. What does have a great impact are women's life stages. There are some subtle differences here and there, such as types of continuous positive airway pressure machines. The ones that are designed for women have masks that are better suited to their facial features, which differ from men's."

A precision medicine approach can be taken to treat any sleep disorder. For insomnia, the approach allows healthcare professionals to employ an appropriate cognitive-behavioral therapy plan or to determine which drugs would be more effective all on the basis of symptoms and the characteristics of the particular case. Regarding sleep apnea, Cano explained, "Taking into account the different anatomical characteristics or the higher prevalence of positional apnea will also allow us to offer different therapeutic alternatives to continuous positive airway pressure, such as mandibular advancement devices or positional therapy devices."

Women should be encouraged to develop good sleep habits. These include taking circadian rhythms into account and aligning lifestyles accordingly. It also means going to bed earlier than the men in the household. For menopausal women, recommended sleep habits range from keeping their bedroom at an ideal temperature, following a diet rich in vegetables to avoid becoming overweight, and exercising daily. While this advice may be more applicable to teenagers, adults can benefit from it as well: electronic devices should be turned off well before bedtime. Whether from a phone screen, a tablet screen, or a TV screen, the light emitted can keep one awake, which can be harmful to one's health.

Cano and Merino have disclosed no relevant financial relationships.

This article was translated from the Medscape Spanish edition.

More:

Hormone Changes: The Star of Every Stage in Women's Sleep - Medscape

Fans react to Hasbulla Magomedov signing with the UFC

MMA fans cant stop making jokes about Hasbulla Magomedov signing with the UFC.

Hasbulla is a social media superstar who suffers from Growth Hormone Deficiency (dwarfism). At 20, Mini Khabib is 3 foot 4 inches and started to get famous when he was seen hanging out with Khabib Nurmagomedov.

Hasbulla has since evolved into somewhat of a household name. He is often jestingly pit against Abdu Rozik, a 19-year old singer from Tajikistan who also suffers from dwarfism.

Hasbulla's massive online presence, with over 2 million instagram followers, has now led to a UFC contract. Although the details have not yet been revealed, the newest UFC signee made the announcement on Twitter by saying:

The announcement of Mini Khabib signing with the UFC shocked MMA fans. One fan made a humorous allusion to the outcome of a fight between Henry Cejudo and Hasbulla:

Check out Hasbulla Magomedov making the official announcement below:

MMA fans jestingly matched up Hasbulla Magomedov with former flyweight (125lbs) champion Henry Cejudo. Triple C joined the fun by posting a video of him calling out the newest UFC signee:

Its not clear what Hasbulla will be doing with the UFC. Mini Khabib will likely make frequent appearances at events for publicity.

Watch Henry Cejudo jokingly call out Hasbulla for a fight in the UFC below:

More from Sportskeeda

Fetching more content...

View post:

"Henry Cejudo is finished" Fans hilariously react to internet celebrity Hasbulla Magomedov signing a deal with the UFC - Sportskeeda

On the first page of the first chapter of his unauthorised and unflinching new biography of Anthony Bourdain, Charles Leerhsen paraphrases George Orwells remark that saints should be considered guilty until proven innocent. Later, Leerhsen makes a more explicit case for pursuing an unvarnished portrait of the beloved chef, writer, and television host. [W]hen we try to pick and choose the lessons to take from a life, he argues, we begin to construct a lie in this case, a lie about a man singularly devoted to truth and opposed to pretension and public relations.

If Leerhsen sounds a bit defensive, its not out of nowhere. Down and Out in Paradise which contains unflattering details about Bourdain and quotes private communications from the final days, and hours, before his suicide in 2018 has been the subject of a nasty controversy that started before it even came out. Bourdains younger brother, Christopher Bourdain, has accused the book of being defamatory, and many of Bourdains friends and colleagues declined to speak to Leerhsen.

Enough did speak, however, to provide the material for an engrossing, penetrating, but often bleak book whose candour crosses the line into something uncomfortable. For example, Leerhsen uses Bourdains final messages with Asia Argento, the Italian actor with whom he had an unhappy and increasingly one-sided romance at the time of his death, as an epigraph, which feels tasteless.

The title Down and Out in Paradise is, of course, a nod to Orwells Down and Out in Paris and London, a favourite book of Bourdains and the model for his bestselling memoir Kitchen Confidential, but also an encapsulation of the question that has haunted his legacy from the time the news first broke of his death in a French hotel room. How could someone loved and admired by millions, and who had what has often been described as the best job on earth (I travel around the world, eat a lot of shit, and basically do whatever the fuck I want, Bourdain once said), be so unhappy as to take his own life?

Leerhsen deftly sketches Bourdains childhood as a would-be rebel in suburban New Jersey, his unhappy period at Vassar College before switching to cooking school and falling in love with the pirate-crew atmosphere of professional kitchens, and his early career as a very average chef who came to realise that he enjoyed writing about food as much as cooking it. After he published the New Yorker essay that became Kitchen Confidential, Bourdain was transformed from a slightly dorky recovering addict whose finances were so bad that he couldnt qualify for a credit card to an iconoclastic, world-traveling television celebrity.

Along the way, however, things began to fall apart. Armed with research drawn from confidential interviews and, apparently Bourdains phone and laptop, Leerhsen describes a man who, at the end of his life, was on difficult terms with his mother and brother and not particularly present in the life of his 11-year-old daughter; had become a boss-from-hell whose increasing obnoxiousness had alienated the few longtime friends he hadnt already unceremoniously ditched; and who, although he had quit heroin and other drugs years earlier, was a very active alcoholic. Bourdain was meeting prostitutes, we are told, and leaning heavily on Viagra, steroids, and human growth hormone to impress the two-decades-younger Argento.

Leerhsen speculates that Bourdain was grappling with a sense that hed materially achieved everything a younger him craved but had become a person rich, prickly, lonely, in need of constant validation he despised.

Leerhsen, who has a background in magazine writing, approaches biography not as a dry accumulation of facts but as something ruminative, chatty, and essayistic. Hes a stylist with a knack for winding sentences, and a nice eye, or ear, for the vivid: Bourdains face was a big, beautifully cragged-out Easter Island mask through which he somehow both eagerly and warily surveilled the world.

For all its perceptiveness, Down and Out in Paradise is marred by its tendency to constantly tie Bourdains life to the circumstances of his death: the book returns frequently to the subject, constantly foreshadows it, and closes, somewhat abruptly, with his funeral. That short-changes Bourdain. His suicide may have been the final act of his life, but it was hardly, by a long shot, the most interesting.

Down and Out in Paradise: The Life of Anthony Bourdain is published by Simon & Schuster.

Visit link:

Down and Out in Paradise review a disservice to Anthony Bourdain - The Guardian

CORONADO, Calif.

Two senior Navy SEAL leaders and a senior medical officer received reprimands in connection with the February death of a SEAL trainee at the services school in Coronado, officials said this week.

Seaman Kyle Mullen, 24, died Feb. 4 after completing Hell Week, a strenuous 5-day training session that ends the first phase of the notoriously rigorous Basic Underwater Demolition/SEAL training course. The Navy describes BUD/S as among the most mentally and physically demanding training in the world.

The line-of-duty investigation into Mullens death, released by the service Wednesday, raises questions about how the Navy supervises trainees, who might be discouraged from reporting medical problems to instructors for fear of being dropped or rolled back in training.

More than half of Navy SEAL trainees dont complete the first phase of training.

Mullen was suffering from pneumonia and had a swimming-induced pulmonary edema, a condition in which water accumulates in the lungs during surface or underwater swimming, an autopsy found. SEAL trainees are susceptible to the condition due to the nature of their training they are sent in and out of the cold waters of the Pacific on the Silver Strand in Coronado, where the Naval Special Warfare Center is located.

The sailors heart was also enlarged, according to the autopsy. Mullen died of cardiac arrest caused by acute pneumonia. His enlarged heart was a contributing factor, the autopsy said.

The Navy medical examiner did not test for drugs. However, Navy medical experts who reviewed the findings noted in the report that performance-enhancing drugs steroids and human growth hormone were found in his belongings. Had he taken them, they could have contributed to his heart condition.

After discovering the drugs, Naval Special Warfare launched an investigation and found about 40 other SEAL trainees had used performance-enhancing drugs, the New York Times reported in August.

Mullen had already been diagnosed with the pulmonary edema three weeks before Hell Week, according to the report.

But several of Mullens classmates told investigators that he struggled to breathe and was spitting up blood during Hell Week in the days before his death. Although he was coughing up blood and pink foam, Mullens classmates said the sailor didnt want to seek medical care because he didnt want to roll back in training. Mullen had already been held back once due to heatstroke, the report said.

Mullens legs also began to swell during the week, something the Navy told trainees was normal during Hell Week. Mullen gained 22 pounds during Hell Week, the report said.

Navy medical personnel gave Mullen supplemental oxygen on Feb. 3 and the morning of the day he died, the report said.

Mullen finished Hell Week the morning of Feb. 4 and was taken to his barracks room in a wheelchair to recover. A medical officer on duty recommended calling 911, but it did not happen. When Mullen became unresponsive in his room about 90 minutes later, paramedics were called. A Gatorade bottle full of the pink fluid hed been coughing up for hours was found next to him, the investigation said.

He died at Sharp Coronado Hospital.

The report concludes that Mullen died in the line of duty and not due to his own misconduct.

The incident has already sparked changes in how the health of sailors is monitored during Hell Week, the Associated Press reported, and led to expanded testing for performance-enhancing drugs.

Capt. Brian Drechsler, the commanding officer of the Naval Special Warfare Center, received a reprimand letter as a result of the investigation, according to a Naval Special Warfare spokesperson. Capt. Brad Geary, the former commander of Naval Special Warfares Basic Training center, and a senior medical officer also received letters. Geary has since moved on to another job in a routine rotation. None of the officers were removed from their jobs, and the reprimands were non-punitive, the spokesperson said.

A separate command investigation into Mullens death is ongoing, the spokesperson said, and the administrative actions against the officers will be reviewed.

A review of Hell Week in consultation with 87 SEALs was included in the report. The vast majority of those surveyed said theyd encountered conditions as challenging as Hell Week during real-world SEAL operations.

Originally posted here:

Navy SEAL leaders reprimanded over trainee's death in 'Hell Week' - Los Angeles Times

Crops often face harsh growing environments. Instead of using energy for growth, factors such as disease, extreme temperatures, and salty soils force plants to use it to respond to the resulting stress. This is known as the growth-stress response trade-off. Now, a group of researchers from Nagoya University has discovered a previously unknown pathway that regulates whether a plant uses its resources for growth or stress tolerance. This discovery could enable the stress response to be controlled under agricultural conditions, increasing crop yields. They published the findings in the journalScience.

A research group, led by Professor Yoshikatsu Matsubayashi and Assistant Professor Mari Ohnishi of the Graduate School of Science at Nagoya University in Japan, investigated the role of hormones and their receptors in the plant stress response. They focused on three receptors for which the corresponding hormone had not yet been identified. Using thale cress (Arabidopsis thaliana), a small flowering plant, they discovered the PSY family, which functions as a hormone, binding to these receptors and mediating the switch between the stress response and growth.

When the researchers investigated the pathway involved, they made an unexpected discovery. Usually, receptors and hormones function like locks and keys, with the hormone (in this case, a peptide PSY hormone) acting as a key that is necessary to start a biological process. However, in this study, plant cells that did not produce PSY nonetheless had an active stress response. Therefore, this suggests that instead of activating the stress response, the presence of the PSY key in the receptor lock keeps it switched off.

To test the nature of stress responses, the researchers grew plants under extremely stressful conditions using heat, salt, and also infected them with bacteria. Plants that were either deficient in PSY receptors or were continuously fed the hormone PSY failed to respond adequately to stress, resulting in reduced survival. The scientists concluded that stressed plants stop releasing PSY, the absence of which induces stress response genes.

To explain this phenomenon, the researchers proposed a mechanism in which damaged cells reduce the concentration of PSY hormones in the cell layers next to the damaged sites. This lack of PSY triggers the stress response. Importantly, this may explain why even damaged plants can send messages. Rather than using their limited resources to create a new signal, an impaired plant cellmay instead stop the release of the PSY hormone, activating the stress response. Such a mechanism would balance stress tolerance with associated energy costs. As a result, even under the most stressful environmental conditions, plants can still grow by managing their limited resources.

Most of the mechanisms found in Arabidopsis are found in other plants. Therefore, our results apply to all crops, explained Matsubayashi. This mechanism makes it possible to artificially control the balance between stress tolerance and yield, which is a trade-off relationship. In recent years, an increasing number of crop plants have been grown in plant factories. When crops are grown indoors, it is a low-stress environment and the stress response system that is needed to withstand the fluctuating natural outdoor environment is not always necessary. Generating cultivars with reduced PSY receptor activity in plant factories may lead to higher yields in these controlled environments.

View original post here:

Discovery Of Family Of Hormones May Be Key To Increased Crop Yields - Eurasia Review

This comprehensive Report on Protein Therapeutics Market provides real information about the statistics and state of the global and regional market. Its scope study extends from the market situation to comparative pricing between the main players, spending in specific market areas, and profits. It represents a comprehensive and succinct analysis report of the main competitor and price statistics with a view to helping beginners establish their place and survive in the market. In addition, it also focuses on the market overview for the coming period from 2022 to 2030. This proved to be a great help for entrepreneurs. This detailed market research is heavily based on information received during interviews with key leaders, research, and innovative resources.

Download Sample Copy with TOC, Graphs & List of Figures @ https://www.stratagemmarketinsights.com/sample/125208

In addition to the information presented in this report on the Protein Therapeutics Market, it includes financial losses incurred as a result of COVID-19. It also explains how the most important business sectors in the market are coping with the epidemic and how to get out of it. This market report is a way to present accurate information on company profiles and competitiveness analyses in an orderly manner. It anticipates competition in the market for the planned period from 2022 to 2030. This Protein Therapeutics Market study also looks at industry channels and performance rates to help key players stay ahead of the competition.

The major players covered in Protein Therapeutics Market:

Abbott Laboratories Amgen Inc. Baxter International Inc. Eli Lilly And Company F. Hoffmann La Roche Ltd Johnson and Johnson (Janssen Pharmaceuticals) Merck and Co. Inc. Novo Nordisk AS Pfizer Inc. Sanofi

Market Segmentation: By Type

Monoclonal Antibodies Insulin Fusion Protein Erythropoietin Interferon Human Growth Hormone Follicle Stimulating Hormone

Market Segmentation: By Application

Metabolic Disorders Immunologic Disorders Hematological Disorders Cancer Hormonal Disorders Genetic Disorders Others

Click Here to Get a Sample Copy of the Protein Therapeutics Market Report @https://www.stratagemmarketinsights.com/sample/125208

Key market aspects are illuminated in the report:

Executive Summary: It covers a summary of the most vital studies, the Global Protein Therapeutics market increasing rate, modest circumstances, market trends, drivers and problems as well as macroscopic pointers.

Study Analysis: Covers major companies, vital market segments, the scope of the products offered in the Global Protein Therapeutics Market, the years measured, and the study points.

Company Profile: Each Firm well-defined in this segment is screened based on a product, value, SWOT analysis, ability, and other significant features.

Manufacture by region: This Global Protein Therapeutics report offers data on imports and exports, sales, production, and key companies in all studied regional markets

Market Segmentation: By Geographical Analysis

The Middle East and Africa (GCC Countries and Egypt)North America (the United States, Mexico, and Canada)South America (Brazil etc.)Europe (Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific (Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

For Any Query or Customization @https://www.stratagemmarketinsights.com/quiry/125208

Key questions answered in the report include:

Who are the key market players in the Protein Therapeutics Market?Which are the major regions for dissimilar trades that are expected to eyewitness astonishing growth for the Protein Therapeutics Market?What are the regional growth trends and the leading revenue-generating regions for the Protein Therapeutics Market?What will be the market size and the growth rate by the end of the forecast period?What are the key Protein Therapeutics Market trends impacting the growth of the market?What are the major Product Types of the Protein Therapeutics Market?What are the major applications of Protein Therapeutics Market?Which Protein Therapeutics Market Services technologies will top the market in the next 7 years?

Table of Contents:

Global Protein Therapeutics Market Research Report 20222030

Chapter 1 Protein Therapeutics Market OverviewChapter 2 Global Economic Impact on IndustryChapter 3 Global Market Competition by ManufacturersChapter 4 Global Production, Revenue (Value) by RegionChapter 5 Global Supply (Production), Consumption, Export, Import by RegionsChapter 6 Global Production, Revenue (Value), Price Trend by TypeChapter 7 Global Market Analysis by ApplicationChapter 8 Manufacturing Cost AnalysisChapter 9 Industrial Chain, Sourcing Strategy and Downstream BuyersChapter 10 Marketing Strategy Analysis, Distributors/TradersChapter 11 Market Effect Factors AnalysisChapter 12 Global Protein Therapeutics Market Forecast

Buy the Full Research Report of the Global Protein Therapeutics Market @https://www.stratagemmarketinsights.com/cart/125208

If you have any special requirements, please let us know and we will offer you the report as you want. you can also get individual chapter-wise sections or region-wise report versions like North America, Europe or Asia.

Contact Us:

Mr. ShahStratagem Market Insights U.S.A: +1-415-871-0703 UK: +44-203-289-4040 JAPAN: +81-50-5539-1737Email: [emailprotected]

View original post here:

New Technology Developments in Protein Therapeutics Market to Grow during Forecast year 2022-2030 | Abbott Laboratories, Amgen Inc., Baxter...

The Tallest Man Living is one of Guinness World Records most iconic titles.

Tallness has long been a sign of greatness and success in history. The Chinese held it desirous for men to betall, wealthy, and handsometallness coming nominally first. Our times have seen several men of towering stature, whose height has garnered celebrity, steep challenges, and in some cases romance.

Here, well peruse three of the tallest men ever recorded who lived in recent times, or are still living, whove claimed several Guinness World Record titles.

The current title for the Tallest Man Living is held by Sultan Ksen, 39, from Turkey, who, at age 9, became the first man over 8 feet to be measured by Guinness in over 20 years. Guinness has confirmed only 10 reliable cases of men reaching 8 feet in history.

Born on Dec. 10, 1982, Ksen did not experience his growth spurt until age 10. The rest of his family, including his parents, were of average size.Due to his height, he didnt finish school and instead he began working as a farmer to support his family.

Ksen towered a breathtaking 8 feet, 1 inch (246.5 cm) tall when he was measured in February 2009 and claimed the title for the first time. Two years later, at age 26, he broke this record, measuring 8 feet, 2.8 inches (251 cm).

Ksens humongous height was caused by a condition called pituitary gigantism where there is an overproduction of growth hormone in the pituitary gland. This resulted in his hands growing to an incredible 11.22 inches (28.5 cm) from the wrist to the tip of the middle finger, and setting the record for the Largest Hands on a Living Person.

He cites some advantages of being so tall, such as being able to help his mom replace broken lightbulbs and hang curtains. He is a basketball fan and can slam dunk without his feet leaving the ground, though he was unable to play ball in school because he was too tall.

Some of the disadvantages of his height include finding clothes and shoes that fit his lanky limbs. Ksens left foot measures 1 foot, 2.4 inches (36.5 cm), while his right measures 1 foot, 2.0 inches (35.5 cm) in length. Its also terribly difficult for Ksen to fit in a car.

Thankfully, after gaining exposure through Guinness, the gentle giant received revolutionary gamma knife surgery from the University of Virginia on the tumor affecting his pituitary gland, which stopped him from getting any taller.

Ksen hoped his fame would lead to his eventually finding a wife, which it did in 2013 when he married Syrian-born Merve Dibo, who is 9 years his junior, whom hemet through a mutual friend. As fate would have it, the couple parted ways in 2021, reportedly because of a language barrier.

Prior to Ksen, the title holder of the Tallest Man Living was Bao Xi Shun, a goat herder from Chifeng, Inner Mongolia. Born in 1951, by his own account he remained normal in height until the age of 16. He then served in the Peoples Liberation Army for three years before returning to Inner Mongolia to live with his mother.

He claimed the title of Tallest Man Living in 2005, then measuring a knee-wobbling 7 feet, 9 inches (236 cm), towering 3 inches above former Chinese pro basketball player Yao Mings 7feet, 6inches.

Baos tallness resulted from anautoimmune condition called rheumatism, which can cause pain and inflammation in the joints and connective tissues of the body.

He is famous for reportedlyhelping save the lives of two dolphins inDecember 2006 by removing shards of plastic from their stomachs.Bao allegedly used his 3.47-foot- (1.06 meter-) long arms to reach into the dolphins stomachs to retrieve the sharp objects with his hands.

The herdsman, now 70, is typically shown in photographs donning traditional Mongolian dress at cultural events or his wedding.The towering Mongolian married Xia Shujuan, asaleswoman, on March 24, 2007, and they had a son together the following year.

Last but certainly not least, the late Illinoisan Robert Wadlow is still the titleholder of the Tallest Man Ever.

Wadlow was born an average-size baby on Feb. 22, 1918, weighing 8.7 pounds (3.85 kg). His two parents were also of average size, as were his four younger siblings.

Wadlow started to shoot up from there onward. At age 5, he measured a staggering 5 feet, 4 inches (1.63 meters), and was already wearing clothes intended for teenagers. By the age of 8, hed surpassed his 5 foot, 11 inches (180.3 cm) dad,Harold F. Wadlow, in height, and was even able to carry him up the stairs of their family home.

Wadlows height caused him a number of medical issues which only worsened as he grew older and taller.

He endeavored to participate in the same activities as his peers and became a Boy Scout at the age of 13. This required him to get a custom-made uniform, tent, and sleeping bag.

He garnered the title of the Tallest Teenager Ever at age 16, when he reached 8 feet, 0.5 inches (2.45 meters). He graduated from high school in 1936 and then enrolled in college to pursue a career in law.

Later that year, Wadlows soaring height led him to fame, and he embarked on a tour with the hugely popular Ringling Brothers Circus.

When asked in a radio interview if he was bothered by so many people staring at him, he answered, according to Guinness, No, I just overlook them.

Doctors examined Wadlow and determined that his exceptional size, likeKsens, resulted from pituitary gigantism causing excessive levels of human growth hormone. But unlike Ksen, Wadlow never received treatment to stop it.

The mild-mannered American was last measured on June 27, 1940, then stretching a staggering 8 feet, 11.1 inches (2.72 meters) talla record that hasnt been broken to this day.

Wadlow has claimed other records, including the Largest Feet Ever, his tootsies measuring a jaw-dropping 18.5 inches (47 cm) longenough to fill a US size 37AA. Back then, his shoes cost as much as $100, equal to about $1,700 in todays currency.Additionally, he boasted the Largest Hands Ever, with his measuring 12.7 inches (32.3 centimeters) from the wrist to the tip of the middle finger.

But Wadlow also had difficulty getting around. He wore leg braces and used a walking stick. It was his legs that eventually caused his premature death at age 22, on July 15, 1940. He died in a hotel in Manistee, Michigan, from a septic blister on his right ankle caused by his brace, which had been poorly fitted just a week earlier.

In 1986, this human being of unsurpassed stature was honored with his own life-sized statue, which was erected on College Avenue in Alton, opposite the Alton Museum of History and Art. Meanwhile, a number of life-size likenesses of the herculean American continue to stand in museums across the world.

Share your stories with us at emg.inspired@epochtimes.com, and continue to get your daily dose of inspiration by signing up for the Inspired newsletter at TheEpochTimes.com/newsletter

Read the original here:

3 of the World's Tallest Men Ever Recorded Lived in Our DayAnd Some Are Still Towering Over Us Today - The Epoch Times

The first thing you notice about Lionel Messi, quite possibly the greatest soccer player of all time, is that he looks basically like a normal guy. In the post-Beckham era of the Uncannily Handsome Footballer, when it feels like every great player is ridiculously good-looking, Messi is conspicuously nonconforming, standing a diminutive 5'6", squat and thick-necked and illogically pale, sporting a scruffy beard that only goes so far toward obscuring the distinct unchisel of his jawline and a hair-style that can only be described as Supercuts. The second thing you notice about Messi is that his name sounds an awful lot like messiah. The third thing you notice is that he plays like God. Which is why it was so jarring, last week, when he announced that this World Cup, his fifth, will be his last. Fans around the world turned their thoughts to life after Messi, and the position hell one day take among the games saints.

When thinking about Messis legacy, its worth remembering his origins. The son of a steelworker from Rosario, he was discovered as a prodigious 13 year old by Barcelonas scouts, who persuaded his father to sign a contract on a napkin and whisked his still-tiny son off to the clubs famed academy. Lionel struggled with a growth-hormone deficiency, but with a combination of the clubs medical care, tactical education, and his own preternatural skillset, he soon bloomed into the kind of phenomenon that even a club as fabled as Barcelona had never seen. After he made his senior debut, aged 17, the club proceeded to win 10 Spanish league titles and four Champions League trophies. Messi scored a club record 474 goals, many of them casually sublime. Indeed, deep into what shouldve been the autumn of his career, he was still scoring outrageous goals at an outrageous rate. It seemed like he might go on forever.

And then, suddenly, it was over. The club, reckless in its spending, teetered toward insolvency, and had to sell its favorite son in August 2021. With tears at his farewell press conference, Messi was offloaded to Paris Saint-Germain, the superclub bankrolled by the Qatari royal familya place where insolvency will never be a concern, and where, for perhaps the first time in his adult life, Messi foundered at the club level. In his first season playing in Paris alongside fellow megastars Kylian Mbappe and Neymar, he showed flashes of genius, but by his celestial standards it was a barren year. The joy that made him appear a demigod was gone, leaving Lionel to seem merely mortal.

Was his story winding down? It was not. With the World Cup around the corner, he now looks like a player reborn, scoring delightful free kicks, leading Paris Saint-Germain in assists, and looking rejuvenated for Argentina as well. He seems like his old self, which is to say: perhaps the greatest ever.

Like all great sporting argumentsJordan or LeBron, Federer or Nadalfootballs GOAT debate will reign eternal. Plausible arguments can be made for Pele, Maradona, Messi, or Ronaldo. So whether you consider Messi to be the best footballer of all time is a matter of personal preferencebut that he is the most famous player of all time is an indisputable fact. If you have never seen even a single minute of footballeven if you couldnt pick Messi out of a lineup of three men, all of whom were himyou know his name. You have heard it tossed about gleefully, chanted solemnly as incantation, cried out in religious ecstasy. It means Barcelona, it means Argentina, it means the World Cup, it means football in the modern era. Because to witness Messi is to witness a kind of dream, surreal and grand and moving, which is what modern football at its best has proven itself capable of producing.

Go here to see the original:

How Will the World Cup Shape Lionel Messis Legacy? - GQ

Legendary broadcaster Bob Costas on his comeback to MLB postseason series in 22 years

Emmy Award-winning sportscaster Bob Costas will make his return to the MLB postseason series in the American League Division Series for the first time since 2000. Costas will cover the ALDS between the New York Yankees and the Cleveland Guardians in the postseason.

In an interview with "The Athletic," the 70-year-old spoke about his return to broadcasting in the ALDS, saying:

Costas continued:

Costas will join Ron Darling and sideline reporter Lauren Shehadi to make his first appearance in the MLB postseason since the series between the Yankees and Seattle Mariners 22 years ago. He also signed a new deal last year to host the NLCS studio show. The veteran will also serve as the TBS studio host for the 2022 ALCS after his long-awaited return.

Former MLB legend Mark McGwire admitted to using PEDs in an interview with Costas in 2010. McGwire revealed that he took steroids before hitting a then-record 70 homers in 1998, with Sammy Sosa at 66. He also revealed that he used a human growth hormone before his retirement in 2001.

After the interview, Bob Costas defended the star, controversially saying that, despite the wrongdoing, he was a "nice" and "sincere" guy. He said:

McGwire won two World Series championships in his career, with Oakland in 1989 and the St. Louis Cardinals as a coach in 2011. He made it to 12 All-Star games, while winning the AL Rookie of the Year in 1987, with three Silver Slugger awards and one Gold Glove award.

More from Sportskeeda

Fetching more content...

See the original post here:

"It isnt quite like playing, but its the closest thing to it. You remember every pitch" - Legendary broadcaster Bob Costas on his comeback...

Published: Published Date - 11:42 PM, Fri - 14 October 22

Hyderabad: The article is in continuation to the last article about chemical coordination and integration in the human body. Today, lets discuss the functions of the hypothalamus and the pituitary gland. The information can be handy for the upcoming exams.

However, the hormones produced by hypothalamus are of two types, the releasing hormones (which stimulate secretion of pituitary hormones) and the inhibiting hormones (which inhibit secretions of pituitary hormones).

For example, a hypothalamic hormone called Gonadotrophin releasing hormone (GnRH) stimulates the pituitary synthesis and release of gonadotrophins. On the other hand, somatostatin from the hypothalamus inhibits the release of growth hormone from the pituitary. These hormones originating in the hypothalamic neurons pass through axons and are released from their nerve endings. These hormones reach the pituitary gland through a portal circulatory system and regulate the functions of the anterior pituitary. The posterior pituitary is under the direct neural regulation of the hypothalamus.

Pituitary GlandThe pituitary gland is in a bony cavity called sella tursica and is attached to hypothalamus by a stalk.It is divided anatomically into an adenohypophysis and a neurohypophysis. Adenohypophysis consists of two portions, pars distalis and pars intermedia.

The pars distalis region of pituitary, commonly called anterior pituitary, produces growth hormone (GH), prolactin (PRL), thyroid stimulating hormone (TSH), adrenocorticotrophic hormone (ACTH), luteinizing hormone (LH) and follicle stimulating hormone (FSH). Pars intermedia secretes only one hormone called melanocyte stimulating hormone (MSH).

However, in humans, the pars intermedia is almost merged with pars distalis. Neurohypophysis (pars nervosa) also known as posterior pituitary, stores and releases two hormones called oxytocin and vasopressin, which are actually synthesised by the hypothalamus and are transported axonally to neurohypophysis.

Over-secretion of GH stimulates abnormal growth of the body leading to gigantism and low secretion of GH results in stunted growth resulting in pituitary dwarfism. Excess secretion of growth hormone in adults especially in middle age can result in severe disfigurement (especially of the face) called Acromegaly, which may lead to serious complications, and premature death if unchecked. The disease is hard to diagnose in the early stages and often goes undetected for many years, until changes in external features become noticeable.

To be continuedBy

Dr. Modala Mallesh

Subject ExpertPalem, Nakrekal, Nalgonda9989535675

See the original post:

Understand the different functions of pituitary gland - Telangana Today